| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| B2m | Cst3 | ENSRNOP00000023017 | ENSRNOP00000007175 | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. | Cystatin-C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity. Known to inhibit cathepsin B, H, and L; Belongs to the cystatin family. | 0.800 |
| B2m | Cstb | ENSRNOP00000023017 | ENSRNOP00000001593 | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. | Cystatin-B; This is an intracellular thiol proteinase inhibitor; Belongs to the cystatin family. | 0.494 |
| B2m | Ctsb | ENSRNOP00000023017 | ENSRNOP00000014178 | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. | Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (By similarity). Belongs to the peptidase C1 family. | 0.546 |
| B2m | Fth1 | ENSRNOP00000023017 | ENSRNOP00000037803 | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. | Ferritin heavy chain, N-terminally processed; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). | 0.825 |
| Cst3 | B2m | ENSRNOP00000007175 | ENSRNOP00000023017 | Cystatin-C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity. Known to inhibit cathepsin B, H, and L; Belongs to the cystatin family. | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. | 0.800 |
| Cst3 | Cstb | ENSRNOP00000007175 | ENSRNOP00000001593 | Cystatin-C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity. Known to inhibit cathepsin B, H, and L; Belongs to the cystatin family. | Cystatin-B; This is an intracellular thiol proteinase inhibitor; Belongs to the cystatin family. | 0.583 |
| Cst3 | Ctsb | ENSRNOP00000007175 | ENSRNOP00000014178 | Cystatin-C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity. Known to inhibit cathepsin B, H, and L; Belongs to the cystatin family. | Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (By similarity). Belongs to the peptidase C1 family. | 0.861 |
| Cst3 | Ctsl | ENSRNOP00000007175 | ENSRNOP00000025462 | Cystatin-C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity. Known to inhibit cathepsin B, H, and L; Belongs to the cystatin family. | Cathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (Probable). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family. | 0.668 |
| Cst3 | Fth1 | ENSRNOP00000007175 | ENSRNOP00000037803 | Cystatin-C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity. Known to inhibit cathepsin B, H, and L; Belongs to the cystatin family. | Ferritin heavy chain, N-terminally processed; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). | 0.611 |
| Cstb | B2m | ENSRNOP00000001593 | ENSRNOP00000023017 | Cystatin-B; This is an intracellular thiol proteinase inhibitor; Belongs to the cystatin family. | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. | 0.494 |
| Cstb | Cst3 | ENSRNOP00000001593 | ENSRNOP00000007175 | Cystatin-B; This is an intracellular thiol proteinase inhibitor; Belongs to the cystatin family. | Cystatin-C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity. Known to inhibit cathepsin B, H, and L; Belongs to the cystatin family. | 0.583 |
| Cstb | Ctsb | ENSRNOP00000001593 | ENSRNOP00000014178 | Cystatin-B; This is an intracellular thiol proteinase inhibitor; Belongs to the cystatin family. | Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (By similarity). Belongs to the peptidase C1 family. | 0.621 |
| Cstb | Ctsl | ENSRNOP00000001593 | ENSRNOP00000025462 | Cystatin-B; This is an intracellular thiol proteinase inhibitor; Belongs to the cystatin family. | Cathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (Probable). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family. | 0.536 |
| Cstb | Cyss | ENSRNOP00000001593 | ENSRNOP00000044719 | Cystatin-B; This is an intracellular thiol proteinase inhibitor; Belongs to the cystatin family. | Cystatin-S; This protein strongly inhibits papain and ficin, partially inhibits stem bromelain and bovine cathepsin C, but does not inhibit porcine cathepsin B or clostripain. Papain is inhibited non- competitively. | 0.538 |
| Cstb | Fth1 | ENSRNOP00000001593 | ENSRNOP00000037803 | Cystatin-B; This is an intracellular thiol proteinase inhibitor; Belongs to the cystatin family. | Ferritin heavy chain, N-terminally processed; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). | 0.497 |
| Cstb | Pum1 | ENSRNOP00000001593 | ENSRNOP00000015831 | Cystatin-B; This is an intracellular thiol proteinase inhibitor; Belongs to the cystatin family. | Pumilio RNA-binding family member 1. | 0.503 |
| Cstb | Pum2 | ENSRNOP00000001593 | ENSRNOP00000008359 | Cystatin-B; This is an intracellular thiol proteinase inhibitor; Belongs to the cystatin family. | Pumilio RNA-binding family member 2. | 0.503 |
| Cstb | Tmprss11c | ENSRNOP00000001593 | ENSRNOP00000035600 | Cystatin-B; This is an intracellular thiol proteinase inhibitor; Belongs to the cystatin family. | Transmembrane protease serine; Belongs to the peptidase S1 family. | 0.481 |
| Cstb | Tryx5 | ENSRNOP00000001593 | ENSRNOP00000041980 | Cystatin-B; This is an intracellular thiol proteinase inhibitor; Belongs to the cystatin family. | Trypsin X5; Belongs to the peptidase S1 family. | 0.481 |
| Ctsb | B2m | ENSRNOP00000014178 | ENSRNOP00000023017 | Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (By similarity). Belongs to the peptidase C1 family. | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. | 0.546 |
