| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Aire | Cd4 | ENSRNOP00000001611 | ENSRNOP00000021915 | Autoimmune regulator. | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | 0.843 |
| Aire | Cd40 | ENSRNOP00000001611 | ENSRNOP00000052022 | Autoimmune regulator. | Tumor necrosis factor receptor superfamily, member 5, isoform CRA_a. | 0.664 |
| Aire | Cd80 | ENSRNOP00000001611 | ENSRNOP00000002089 | Autoimmune regulator. | CD80 antigen, isoform CRA_a. | 0.723 |
| Aire | Fezf2 | ENSRNOP00000001611 | ENSRNOP00000012452 | Autoimmune regulator. | Zinc finger protein 312 (Predicted). | 0.694 |
| Aire | Foxn1 | ENSRNOP00000001611 | ENSRNOP00000014672 | Autoimmune regulator. | Forkhead box N1. | 0.849 |
| Aire | H3c1 | ENSRNOP00000001611 | ENSRNOP00000064431 | Autoimmune regulator. | Histone H3.1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.679 |
| Aire | H3f3c | ENSRNOP00000001611 | ENSRNOP00000060626 | Autoimmune regulator. | Histone H3; Belongs to the histone H3 family. | 0.668 |
| Aire | LOC100361558 | ENSRNOP00000001611 | ENSRNOP00000004329 | Autoimmune regulator. | Histone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] | 0.717 |
| Aire | LOC684762 | ENSRNOP00000001611 | ENSRNOP00000044600 | Autoimmune regulator. | Histone H3; Belongs to the histone H3 family. | 0.659 |
| Aire | RGD1564447 | ENSRNOP00000001611 | ENSRNOP00000073598 | Autoimmune regulator. | Histone H3; Belongs to the histone H3 family. | 0.668 |
| Cd4 | Aire | ENSRNOP00000021915 | ENSRNOP00000001611 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Autoimmune regulator. | 0.843 |
| Cd4 | Cd40 | ENSRNOP00000021915 | ENSRNOP00000052022 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Tumor necrosis factor receptor superfamily, member 5, isoform CRA_a. | 0.955 |
| Cd4 | Cd80 | ENSRNOP00000021915 | ENSRNOP00000002089 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | CD80 antigen, isoform CRA_a. | 0.968 |
| Cd4 | Foxn1 | ENSRNOP00000021915 | ENSRNOP00000014672 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Forkhead box N1. | 0.698 |
| Cd4 | H3c1 | ENSRNOP00000021915 | ENSRNOP00000064431 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Histone H3.1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.536 |
| Cd4 | H3f3c | ENSRNOP00000021915 | ENSRNOP00000060626 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Histone H3; Belongs to the histone H3 family. | 0.534 |
| Cd4 | LOC100361558 | ENSRNOP00000021915 | ENSRNOP00000004329 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Histone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] | 0.537 |
| Cd4 | LOC684762 | ENSRNOP00000021915 | ENSRNOP00000044600 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Histone H3; Belongs to the histone H3 family. | 0.536 |
| Cd4 | RGD1564447 | ENSRNOP00000021915 | ENSRNOP00000073598 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Histone H3; Belongs to the histone H3 family. | 0.534 |
| Cd40 | Aire | ENSRNOP00000052022 | ENSRNOP00000001611 | Tumor necrosis factor receptor superfamily, member 5, isoform CRA_a. | Autoimmune regulator. | 0.664 |