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Por protein (Rattus norvegicus) - STRING interaction network
"Por" - NADPH--cytochrome P450 reductase in Rattus norvegicus
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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PorNADPH--cytochrome P450 reductase ; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5 (678 aa)    
Predicted Functional Partners:
Papss2
Bifunctional 3’-phosphoadenosine 5’-phosphosulfate synthase 2 (614 aa)
   
  0.980
Papss1
Bifunctional 3’-phosphoadenosine 5’-phosphosulfate synthase 1 (599 aa)
   
  0.979
Cyb5a
Cytochrome b5 ; Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases. It is also involved in several steps of the sterol biosynthesis pathway, particularly in the C-6 double bond introduction during the C-6 desaturation (134 aa)
     
 
  0.952
Hmox1
Heme oxygenase 1 ; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis (289 aa)
       
 
  0.900
Flad1
FAD synthase (490 aa)
   
 
  0.836
Cyp1a2
Cytochrome P450 1A2 ; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation (513 aa)
     
 
  0.815
Cyp2e1
Cytochrome P450 2E1 ; Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites (493 aa)
     
 
  0.814
Cyp2b1
Cytochrome P450 2B1 precursor ; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics (491 aa)
     
 
  0.813
Cyp1a1
Cytochrome P450 1A1 Cytochrome P450MT2A Cytochrome P450MT2B; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics (524 aa)
     
 
  0.812
Zmpste24
CAAX prenyl protease 1 homolog (475 aa)
     
      0.738
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Gunn rats, Norway rat, R. norvegicus, Rattus, Rattus PC12 clone IS, Rattus norvegicus, Rattus rattiscus, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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