STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Crybg3Crystallin beta-gamma domain-containing 3; Belongs to the beta/gamma-crystallin family. (1241 aa)    
Predicted Functional Partners:
Cuedc2
CUE domain-containing protein 2; Controls PGR and ESR1 protein levels through their targeting for ubiquitination and subsequent proteasomal degradation. Belongs to the CUEDC2 family.
      
 0.653
Pom121l12
POM121 transmembrane nucleoporin-like 12.
      
 0.637
Crybg3-2
Uncharacterized protein.
 
 
    0.634
Anapc15
Anaphase-promoting complex subunit 15; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C: not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby contributing to the responsiveness of the spindle assembly checkpoint. Also required for degradation of CDC20 (By similarity).
      
 0.499
Ldha
L-lactate dehydrogenase A chain.
      
 0.483
Phtf1
Putative homeodomain transcription factor 1.
    
 
 0.476
Cryzl1
Crystallin, zeta (Quinone reductase)-like 1.
      
 0.467
Rapgef6
Rap guanine nucleotide exchange factor (GEF) 6 (Predicted), isoform CRA_a.
      
 0.413
Spag6l
Sperm associated antigen 6 (Predicted).
    
 
 0.403
Spag6
Sperm-associated antigen 6-like.
    
 
 0.403
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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