STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Chaf1bChromatin assembly factor 1, subunit B (P60), isoform CRA_a. (572 aa)    
Predicted Functional Partners:
Chaf1a
Chromatin assembly factor 1 subunit A.
   
 0.991
Rbbp4
RB-binding protein 4, chromatin-remodeling factor.
   
 0.975
Asf1b
ASF1 anti-silencing function 1 homolog B (S. cerevisiae) (Predicted).
   
 
 0.936
RGD1563620
Similar to retinoblastoma-binding protein 4.
   
 
 0.915
Asf1a
ASF1 anti-silencing function 1 homolog A (S. cerevisiae) (Predicted), isoform CRA_a.
   
 
 0.870
Pcna
Proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'- phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA rep [...]
   
 
 0.869
Rbbp7
Histone-binding protein RBBP7; Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and [...]
   
 
 0.831
Cbx5
Chromobox homolog 5 (Drosophila HP1a) (Predicted), isoform CRA_a.
   
 
 0.831
Cdc45
Similar to cell division cycle 45 homolog (S. cerevisiae)-like.
   
  
 0.811
Dtl
Denticleless E3 ubiquitin protein ligase homolog.
  
  
 0.799
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.