node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
D4A7L5_RAT | Nup153 | ENSRNOP00000047101 | ENSRNOP00000001979 | Small ubiquitin-related modifier. | Nuclear pore complex protein Nup153; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC [...] | 0.524 |
D4A7L5_RAT | Senp17 | ENSRNOP00000047101 | ENSRNOP00000074844 | Small ubiquitin-related modifier. | Sumo1/sentrin/SMT3-specific peptidase 17. | 0.636 |
D4A7L5_RAT | Senp18 | ENSRNOP00000047101 | ENSRNOP00000050577 | Small ubiquitin-related modifier. | Sumo1/sentrin/SMT3-specific peptidase 18. | 0.413 |
D4A7L5_RAT | Senp2 | ENSRNOP00000047101 | ENSRNOP00000002425 | Small ubiquitin-related modifier. | Sentrin-specific protease 2; Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. May down-regulate CTNNB1 levels and thereby modulate th [...] | 0.792 |
D4A7L5_RAT | Sumo1 | ENSRNOP00000047101 | ENSRNOP00000022048 | Small ubiquitin-related modifier. | Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for insta [...] | 0.438 |
Dvl1 | Dvl2 | ENSRNOP00000026439 | ENSRNOP00000024348 | Segment polarity protein dishevelled homolog DVL-1; Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By simi [...] | Dishevelled segment polarity protein 2. | 0.982 |
Dvl1 | Dvl3 | ENSRNOP00000026439 | ENSRNOP00000002323 | Segment polarity protein dishevelled homolog DVL-1; Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By simi [...] | Dishevelled segment polarity protein 3. | 0.966 |
Dvl1 | Senp17 | ENSRNOP00000026439 | ENSRNOP00000074844 | Segment polarity protein dishevelled homolog DVL-1; Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By simi [...] | Sumo1/sentrin/SMT3-specific peptidase 17. | 0.900 |
Dvl1 | Senp18 | ENSRNOP00000026439 | ENSRNOP00000050577 | Segment polarity protein dishevelled homolog DVL-1; Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By simi [...] | Sumo1/sentrin/SMT3-specific peptidase 18. | 0.900 |
Dvl1 | Senp2 | ENSRNOP00000026439 | ENSRNOP00000002425 | Segment polarity protein dishevelled homolog DVL-1; Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By simi [...] | Sentrin-specific protease 2; Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. May down-regulate CTNNB1 levels and thereby modulate th [...] | 0.900 |
Dvl2 | Dvl1 | ENSRNOP00000024348 | ENSRNOP00000026439 | Dishevelled segment polarity protein 2. | Segment polarity protein dishevelled homolog DVL-1; Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By simi [...] | 0.982 |
Dvl2 | Dvl3 | ENSRNOP00000024348 | ENSRNOP00000002323 | Dishevelled segment polarity protein 2. | Dishevelled segment polarity protein 3. | 0.971 |
Dvl2 | Senp17 | ENSRNOP00000024348 | ENSRNOP00000074844 | Dishevelled segment polarity protein 2. | Sumo1/sentrin/SMT3-specific peptidase 17. | 0.907 |
Dvl2 | Senp18 | ENSRNOP00000024348 | ENSRNOP00000050577 | Dishevelled segment polarity protein 2. | Sumo1/sentrin/SMT3-specific peptidase 18. | 0.900 |
Dvl2 | Senp2 | ENSRNOP00000024348 | ENSRNOP00000002425 | Dishevelled segment polarity protein 2. | Sentrin-specific protease 2; Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. May down-regulate CTNNB1 levels and thereby modulate th [...] | 0.900 |
Dvl3 | Dvl1 | ENSRNOP00000002323 | ENSRNOP00000026439 | Dishevelled segment polarity protein 3. | Segment polarity protein dishevelled homolog DVL-1; Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By simi [...] | 0.966 |
Dvl3 | Dvl2 | ENSRNOP00000002323 | ENSRNOP00000024348 | Dishevelled segment polarity protein 3. | Dishevelled segment polarity protein 2. | 0.971 |
Dvl3 | Senp17 | ENSRNOP00000002323 | ENSRNOP00000074844 | Dishevelled segment polarity protein 3. | Sumo1/sentrin/SMT3-specific peptidase 17. | 0.909 |
Dvl3 | Senp18 | ENSRNOP00000002323 | ENSRNOP00000050577 | Dishevelled segment polarity protein 3. | Sumo1/sentrin/SMT3-specific peptidase 18. | 0.900 |
Dvl3 | Senp2 | ENSRNOP00000002323 | ENSRNOP00000002425 | Dishevelled segment polarity protein 3. | Sentrin-specific protease 2; Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. May down-regulate CTNNB1 levels and thereby modulate th [...] | 0.900 |