STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CrklCrk-like protein; May mediate the transduction of intracellular signals. Belongs to the CRK family. (303 aa)    
Predicted Functional Partners:
Rapgef1
Rap guanine nucleotide exchange factor 1.
    
 0.999
Cbl
Cbl proto-oncogene.
    
 0.999
Bcar1
Breast cancer anti-estrogen resistance protein 1; Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. Implicated in induction of cell migration (By similarity).
    
 0.992
Pxn
Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family.
    
 0.990
Gab1
GRB2-associated-binding protein 1.
    
 0.984
Egfr
Receptor protein-tyrosine kinase.
    
 0.982
Dock1
Dedicator of cyto-kinesis 1; Belongs to the DOCK family.
    
 0.980
Abl1
Tyrosine-protein kinase.
    
0.964
Abl2
Tyrosine-protein kinase.
    
0.964
Frs2
Fibroblast growth factor receptor substrate 2.
   
 0.964
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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