| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Fzd2 | Fzd3 | ENSRNOP00000036154 | ENSRNOP00000067360 | Frizzled-2; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pa [...] | Frizzled homolog 3 (Drosophila), isoform CRA_a; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.470 |
| Fzd2 | Fzd4 | ENSRNOP00000036154 | ENSRNOP00000023205 | Frizzled-2; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pa [...] | Frizzled-4; Receptor for Wnt proteins (By similarity). Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes (By similarity). Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP) (By similarity). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoti [...] | 0.854 |
| Fzd2 | Fzd6 | ENSRNOP00000036154 | ENSRNOP00000006195 | Frizzled-2; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pa [...] | Frizzled homolog 6 (Drosophila); Belongs to the G-protein coupled receptor Fz/Smo family. | 0.723 |
| Fzd2 | Fzd7 | ENSRNOP00000036154 | ENSRNOP00000021569 | Frizzled-2; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pa [...] | Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.402 |
| Fzd2 | Fzd9 | ENSRNOP00000036154 | ENSRNOP00000001973 | Frizzled-2; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pa [...] | Frizzled-9; Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway (By similarity). May play a role in neural progenitor cells (NPCs) viability through the beta- catenin canonical signaling pathway by negatively regulating cell [...] | 0.454 |
| Fzd2 | Gpc4 | ENSRNOP00000036154 | ENSRNOP00000003282 | Frizzled-2; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pa [...] | Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. | 0.907 |
| Fzd2 | Gpc6 | ENSRNOP00000036154 | ENSRNOP00000068304 | Frizzled-2; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pa [...] | Similar to Gpc6 protein (Predicted); Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. | 0.597 |
| Fzd3 | Fzd2 | ENSRNOP00000067360 | ENSRNOP00000036154 | Frizzled homolog 3 (Drosophila), isoform CRA_a; Belongs to the G-protein coupled receptor Fz/Smo family. | Frizzled-2; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pa [...] | 0.470 |
| Fzd3 | Fzd4 | ENSRNOP00000067360 | ENSRNOP00000023205 | Frizzled homolog 3 (Drosophila), isoform CRA_a; Belongs to the G-protein coupled receptor Fz/Smo family. | Frizzled-4; Receptor for Wnt proteins (By similarity). Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes (By similarity). Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP) (By similarity). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoti [...] | 0.501 |
| Fzd3 | Fzd6 | ENSRNOP00000067360 | ENSRNOP00000006195 | Frizzled homolog 3 (Drosophila), isoform CRA_a; Belongs to the G-protein coupled receptor Fz/Smo family. | Frizzled homolog 6 (Drosophila); Belongs to the G-protein coupled receptor Fz/Smo family. | 0.629 |
| Fzd3 | Gpc4 | ENSRNOP00000067360 | ENSRNOP00000003282 | Frizzled homolog 3 (Drosophila), isoform CRA_a; Belongs to the G-protein coupled receptor Fz/Smo family. | Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. | 0.892 |
| Fzd3 | Gpc6 | ENSRNOP00000067360 | ENSRNOP00000068304 | Frizzled homolog 3 (Drosophila), isoform CRA_a; Belongs to the G-protein coupled receptor Fz/Smo family. | Similar to Gpc6 protein (Predicted); Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. | 0.741 |
| Fzd4 | Fzd2 | ENSRNOP00000023205 | ENSRNOP00000036154 | Frizzled-4; Receptor for Wnt proteins (By similarity). Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes (By similarity). Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP) (By similarity). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoti [...] | Frizzled-2; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pa [...] | 0.854 |
| Fzd4 | Fzd3 | ENSRNOP00000023205 | ENSRNOP00000067360 | Frizzled-4; Receptor for Wnt proteins (By similarity). Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes (By similarity). Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP) (By similarity). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoti [...] | Frizzled homolog 3 (Drosophila), isoform CRA_a; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.501 |
| Fzd4 | Fzd6 | ENSRNOP00000023205 | ENSRNOP00000006195 | Frizzled-4; Receptor for Wnt proteins (By similarity). Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes (By similarity). Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP) (By similarity). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoti [...] | Frizzled homolog 6 (Drosophila); Belongs to the G-protein coupled receptor Fz/Smo family. | 0.870 |
| Fzd4 | Fzd7 | ENSRNOP00000023205 | ENSRNOP00000021569 | Frizzled-4; Receptor for Wnt proteins (By similarity). Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes (By similarity). Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP) (By similarity). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoti [...] | Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.645 |
| Fzd4 | Gpc4 | ENSRNOP00000023205 | ENSRNOP00000003282 | Frizzled-4; Receptor for Wnt proteins (By similarity). Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes (By similarity). Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP) (By similarity). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoti [...] | Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. | 0.892 |
| Fzd4 | Gpc6 | ENSRNOP00000023205 | ENSRNOP00000068304 | Frizzled-4; Receptor for Wnt proteins (By similarity). Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes (By similarity). Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP) (By similarity). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoti [...] | Similar to Gpc6 protein (Predicted); Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. | 0.741 |
| Fzd6 | Fzd2 | ENSRNOP00000006195 | ENSRNOP00000036154 | Frizzled homolog 6 (Drosophila); Belongs to the G-protein coupled receptor Fz/Smo family. | Frizzled-2; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pa [...] | 0.723 |
| Fzd6 | Fzd3 | ENSRNOP00000006195 | ENSRNOP00000067360 | Frizzled homolog 6 (Drosophila); Belongs to the G-protein coupled receptor Fz/Smo family. | Frizzled homolog 3 (Drosophila), isoform CRA_a; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.629 |
