| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| A0A0G2JXT5_RAT | Bag3 | ENSRNOP00000070396 | ENSRNOP00000027616 | LITAF domain-containing protein. | Bcl2-associated athanogene 3. | 0.680 |
| A0A0G2JXT5_RAT | Il6 | ENSRNOP00000070396 | ENSRNOP00000013732 | LITAF domain-containing protein. | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | 0.466 |
| A0A0G2JXT5_RAT | Itch | ENSRNOP00000070396 | ENSRNOP00000075116 | LITAF domain-containing protein. | E3 ubiquitin-protein ligase. | 0.549 |
| A0A0G2JXT5_RAT | Litaf | ENSRNOP00000070396 | ENSRNOP00000003412 | LITAF domain-containing protein. | Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog; Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation. Plays a role in targeting endocytosed EGFR and ERGG3 for lysosomal degradation, and thereby helps downregulate downstream signaling cascades. Helps recruit the ESCRT complex components TSG101, HGS and STAM to cytoplasmic membranes. Probably plays a role in regulating protein degradation via its interaction with NEDD4. May also contribute to the regulation of gene expression in the nucleus. Binds DNA (in vitro) and may [...] | 0.913 |
| A0A0G2JXT5_RAT | Nedd4 | ENSRNOP00000070396 | ENSRNOP00000074683 | LITAF domain-containing protein. | E3 ubiquitin-protein ligase NEDD4; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins (By similarity). Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Promotes ubiquitination of RAPGEF2. Involved in the pathway leading to the degradation of VEGFR-2/K [...] | 0.599 |
| A0A0G2JXT5_RAT | Nedd4l | ENSRNOP00000070396 | ENSRNOP00000070352 | LITAF domain-containing protein. | NEDD4-like E3 ubiquitin protein ligase. | 0.599 |
| A0A0G2JXT5_RAT | Sh3tc2 | ENSRNOP00000070396 | ENSRNOP00000026174 | LITAF domain-containing protein. | SH3 domain and tetratricopeptide repeats 2. | 0.443 |
| A0A0G2JXT5_RAT | Stam2 | ENSRNOP00000070396 | ENSRNOP00000033318 | LITAF domain-containing protein. | Signal transducing adapter molecule 2; Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking process [...] | 0.518 |
| A0A0G2JXT5_RAT | Tsg101 | ENSRNOP00000070396 | ENSRNOP00000018194 | LITAF domain-containing protein. | Tumor susceptibility gene 101 protein; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). It may also play a role in the [...] | 0.550 |
| Bag3 | A0A0G2JXT5_RAT | ENSRNOP00000027616 | ENSRNOP00000070396 | Bcl2-associated athanogene 3. | LITAF domain-containing protein. | 0.680 |
| Bag3 | Litaf | ENSRNOP00000027616 | ENSRNOP00000003412 | Bcl2-associated athanogene 3. | Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog; Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation. Plays a role in targeting endocytosed EGFR and ERGG3 for lysosomal degradation, and thereby helps downregulate downstream signaling cascades. Helps recruit the ESCRT complex components TSG101, HGS and STAM to cytoplasmic membranes. Probably plays a role in regulating protein degradation via its interaction with NEDD4. May also contribute to the regulation of gene expression in the nucleus. Binds DNA (in vitro) and may [...] | 0.811 |
| Il6 | A0A0G2JXT5_RAT | ENSRNOP00000013732 | ENSRNOP00000070396 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | LITAF domain-containing protein. | 0.466 |
| Il6 | Litaf | ENSRNOP00000013732 | ENSRNOP00000003412 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog; Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation. Plays a role in targeting endocytosed EGFR and ERGG3 for lysosomal degradation, and thereby helps downregulate downstream signaling cascades. Helps recruit the ESCRT complex components TSG101, HGS and STAM to cytoplasmic membranes. Probably plays a role in regulating protein degradation via its interaction with NEDD4. May also contribute to the regulation of gene expression in the nucleus. Binds DNA (in vitro) and may [...] | 0.647 |
| Il6 | Tsg101 | ENSRNOP00000013732 | ENSRNOP00000018194 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | Tumor susceptibility gene 101 protein; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). It may also play a role in the [...] | 0.473 |
| Itch | A0A0G2JXT5_RAT | ENSRNOP00000075116 | ENSRNOP00000070396 | E3 ubiquitin-protein ligase. | LITAF domain-containing protein. | 0.549 |
| Itch | Litaf | ENSRNOP00000075116 | ENSRNOP00000003412 | E3 ubiquitin-protein ligase. | Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog; Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation. Plays a role in targeting endocytosed EGFR and ERGG3 for lysosomal degradation, and thereby helps downregulate downstream signaling cascades. Helps recruit the ESCRT complex components TSG101, HGS and STAM to cytoplasmic membranes. Probably plays a role in regulating protein degradation via its interaction with NEDD4. May also contribute to the regulation of gene expression in the nucleus. Binds DNA (in vitro) and may [...] | 0.643 |
| Itch | Nedd4 | ENSRNOP00000075116 | ENSRNOP00000074683 | E3 ubiquitin-protein ligase. | E3 ubiquitin-protein ligase NEDD4; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins (By similarity). Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Promotes ubiquitination of RAPGEF2. Involved in the pathway leading to the degradation of VEGFR-2/K [...] | 0.860 |
| Itch | Nedd4l | ENSRNOP00000075116 | ENSRNOP00000070352 | E3 ubiquitin-protein ligase. | NEDD4-like E3 ubiquitin protein ligase. | 0.852 |
| Litaf | A0A0G2JXT5_RAT | ENSRNOP00000003412 | ENSRNOP00000070396 | Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog; Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation. Plays a role in targeting endocytosed EGFR and ERGG3 for lysosomal degradation, and thereby helps downregulate downstream signaling cascades. Helps recruit the ESCRT complex components TSG101, HGS and STAM to cytoplasmic membranes. Probably plays a role in regulating protein degradation via its interaction with NEDD4. May also contribute to the regulation of gene expression in the nucleus. Binds DNA (in vitro) and may [...] | LITAF domain-containing protein. | 0.913 |
| Litaf | Bag3 | ENSRNOP00000003412 | ENSRNOP00000027616 | Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog; Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation. Plays a role in targeting endocytosed EGFR and ERGG3 for lysosomal degradation, and thereby helps downregulate downstream signaling cascades. Helps recruit the ESCRT complex components TSG101, HGS and STAM to cytoplasmic membranes. Probably plays a role in regulating protein degradation via its interaction with NEDD4. May also contribute to the regulation of gene expression in the nucleus. Binds DNA (in vitro) and may [...] | Bcl2-associated athanogene 3. | 0.811 |
