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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Gpr137bG protein-coupled receptor 137B. (361 aa)    
Predicted Functional Partners:
Gpr108
Protein GPR108.
      
 0.603
Gpr155
G protein-coupled receptor 155 (Predicted), isoform CRA_a.
      
 0.586
Tmem185a
Transmembrane protein 185A.
   
  
 0.583
Tm7sf3
Transmembrane 7 superfamily member 3; Involved in the inhibition of cytokine-induced death of pancreatic beta cells (By similarity). Involved in the promotion of insulin secretion from pancreatic beta cells (By similarity). Is a downstream transcriptional target of p53/TP53, and acts as a pro- survival homeostatic factor that attenuates the development of cellular stress. Maintains protein homeostasis and promotes cell survival through attenuation of endoplasmic reticulum (ER) stress and the subsequent induction of unfolded protein response (UPR) (By similarity).
   
  
 0.573
Gpr152
G protein-coupled receptor 152; Belongs to the G-protein coupled receptor 1 family.
      
 0.556
Gpr107
Protein GPR107; Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor. Involved in blood sugar regulation through the induction of glucagon in response to low glucose. Belongs to the LU7TM family.
   
  
 0.551
Gprc5c
G-protein coupled receptor family C group 5 member C; This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G- protein signaling pathways.
   
  
 0.543
Gpr82
G protein-coupled receptor 82.
      
 0.525
Gpr149
Probable G-protein coupled receptor 149; Orphan receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.509
Rnf227
Similar to RIKEN cDNA A030009H04.
      
 0.473
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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