node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Abhd17a | Abhd17c | ENSRNOP00000024576 | ENSRNOP00000017362 | Alpha/beta hydrolase domain-containing protein 17A; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS (By similarity). Has depalmitoylating activity towards DLG4/PSD95. May have depalmitoylating activity towards MAP6. | Alpha/beta hydrolase domain-containing protein 17C; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards DLG4/PSD95. | 0.416 |
Abhd17a | Lypla2 | ENSRNOP00000024576 | ENSRNOP00000014415 | Alpha/beta hydrolase domain-containing protein 17A; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS (By similarity). Has depalmitoylating activity towards DLG4/PSD95. May have depalmitoylating activity towards MAP6. | Acyl-protein thioesterase 2; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS. Deacylates GAP43. Mediates depalmitoylation of ZDHHC6 (By similarity). Has lysophospholipase activity (By similarity). | 0.554 |
Abhd17a | Zdhhc15 | ENSRNOP00000024576 | ENSRNOP00000003714 | Alpha/beta hydrolase domain-containing protein 17A; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS (By similarity). Has depalmitoylating activity towards DLG4/PSD95. May have depalmitoylating activity towards MAP6. | Palmitoyltransferase ZDHHC15; Catalyzes palmitoylation of Cys residues on target proteins. Catalyzes palmitoylation of GAP43 and DLG4/PSD95. | 0.453 |
Abhd17c | Abhd17a | ENSRNOP00000017362 | ENSRNOP00000024576 | Alpha/beta hydrolase domain-containing protein 17C; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards DLG4/PSD95. | Alpha/beta hydrolase domain-containing protein 17A; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS (By similarity). Has depalmitoylating activity towards DLG4/PSD95. May have depalmitoylating activity towards MAP6. | 0.416 |
Abhd17c | Lypla2 | ENSRNOP00000017362 | ENSRNOP00000014415 | Alpha/beta hydrolase domain-containing protein 17C; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards DLG4/PSD95. | Acyl-protein thioesterase 2; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS. Deacylates GAP43. Mediates depalmitoylation of ZDHHC6 (By similarity). Has lysophospholipase activity (By similarity). | 0.423 |
Abhd17c | Zdhhc15 | ENSRNOP00000017362 | ENSRNOP00000003714 | Alpha/beta hydrolase domain-containing protein 17C; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards DLG4/PSD95. | Palmitoyltransferase ZDHHC15; Catalyzes palmitoylation of Cys residues on target proteins. Catalyzes palmitoylation of GAP43 and DLG4/PSD95. | 0.474 |
Asb12 | Zdhhc15 | ENSRNOP00000005663 | ENSRNOP00000003714 | Ankyrin repeat and SOCS box-containing 12. | Palmitoyltransferase ZDHHC15; Catalyzes palmitoylation of Cys residues on target proteins. Catalyzes palmitoylation of GAP43 and DLG4/PSD95. | 0.634 |
Dlg4 | Snap25 | ENSRNOP00000074184 | ENSRNOP00000007998 | Disks large homolog 4; Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated stat [...] | Synaptosomal-associated protein; Belongs to the SNAP-25 family. | 0.775 |
Dlg4 | Zdhhc15 | ENSRNOP00000074184 | ENSRNOP00000003714 | Disks large homolog 4; Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated stat [...] | Palmitoyltransferase ZDHHC15; Catalyzes palmitoylation of Cys residues on target proteins. Catalyzes palmitoylation of GAP43 and DLG4/PSD95. | 0.446 |
Dnajc5 | Snap25 | ENSRNOP00000020581 | ENSRNOP00000007998 | DnaJ homolog subfamily C member 5; Acts as a general chaperone in regulated exocytosis (By similarity). Acts as a co-chaperone for the SNARE protein SNAP-25 (By similarity). Involved in the calcium-mediated control of a late stage of exocytosis (By similarity). May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity). | Synaptosomal-associated protein; Belongs to the SNAP-25 family. | 0.732 |
Dnajc5 | Zdhhc15 | ENSRNOP00000020581 | ENSRNOP00000003714 | DnaJ homolog subfamily C member 5; Acts as a general chaperone in regulated exocytosis (By similarity). Acts as a co-chaperone for the SNARE protein SNAP-25 (By similarity). Involved in the calcium-mediated control of a late stage of exocytosis (By similarity). May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity). | Palmitoyltransferase ZDHHC15; Catalyzes palmitoylation of Cys residues on target proteins. Catalyzes palmitoylation of GAP43 and DLG4/PSD95. | 0.472 |
Dnajc5 | Zdhhc17 | ENSRNOP00000020581 | ENSRNOP00000005078 | DnaJ homolog subfamily C member 5; Acts as a general chaperone in regulated exocytosis (By similarity). Acts as a co-chaperone for the SNARE protein SNAP-25 (By similarity). Involved in the calcium-mediated control of a late stage of exocytosis (By similarity). May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity). | Palmitoyltransferase ZDHHC17; Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT. May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. May play a role in Mg(2+) transport; Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily. | 0.596 |
Golga7 | Zdhhc15 | ENSRNOP00000033324 | ENSRNOP00000003714 | Golgin subfamily A member 7; May be involved in protein transport from Golgi to cell surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS (By similarity); Belongs to the ERF4 family. | Palmitoyltransferase ZDHHC15; Catalyzes palmitoylation of Cys residues on target proteins. Catalyzes palmitoylation of GAP43 and DLG4/PSD95. | 0.465 |
Lypla2 | Abhd17a | ENSRNOP00000014415 | ENSRNOP00000024576 | Acyl-protein thioesterase 2; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS. Deacylates GAP43. Mediates depalmitoylation of ZDHHC6 (By similarity). Has lysophospholipase activity (By similarity). | Alpha/beta hydrolase domain-containing protein 17A; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS (By similarity). Has depalmitoylating activity towards DLG4/PSD95. May have depalmitoylating activity towards MAP6. | 0.554 |
Lypla2 | Abhd17c | ENSRNOP00000014415 | ENSRNOP00000017362 | Acyl-protein thioesterase 2; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS. Deacylates GAP43. Mediates depalmitoylation of ZDHHC6 (By similarity). Has lysophospholipase activity (By similarity). | Alpha/beta hydrolase domain-containing protein 17C; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards DLG4/PSD95. | 0.423 |
Lypla2 | Zdhhc15 | ENSRNOP00000014415 | ENSRNOP00000003714 | Acyl-protein thioesterase 2; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS. Deacylates GAP43. Mediates depalmitoylation of ZDHHC6 (By similarity). Has lysophospholipase activity (By similarity). | Palmitoyltransferase ZDHHC15; Catalyzes palmitoylation of Cys residues on target proteins. Catalyzes palmitoylation of GAP43 and DLG4/PSD95. | 0.457 |
Lypla2 | Zdhhc17 | ENSRNOP00000014415 | ENSRNOP00000005078 | Acyl-protein thioesterase 2; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS. Deacylates GAP43. Mediates depalmitoylation of ZDHHC6 (By similarity). Has lysophospholipase activity (By similarity). | Palmitoyltransferase ZDHHC17; Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT. May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. May play a role in Mg(2+) transport; Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily. | 0.504 |
Ska1 | Zdhhc15 | ENSRNOP00000020637 | ENSRNOP00000003714 | Spindle and kinetochore-associated protein 1; Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a [...] | Palmitoyltransferase ZDHHC15; Catalyzes palmitoylation of Cys residues on target proteins. Catalyzes palmitoylation of GAP43 and DLG4/PSD95. | 0.445 |
Snap25 | Dlg4 | ENSRNOP00000007998 | ENSRNOP00000074184 | Synaptosomal-associated protein; Belongs to the SNAP-25 family. | Disks large homolog 4; Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated stat [...] | 0.775 |
Snap25 | Dnajc5 | ENSRNOP00000007998 | ENSRNOP00000020581 | Synaptosomal-associated protein; Belongs to the SNAP-25 family. | DnaJ homolog subfamily C member 5; Acts as a general chaperone in regulated exocytosis (By similarity). Acts as a co-chaperone for the SNARE protein SNAP-25 (By similarity). Involved in the calcium-mediated control of a late stage of exocytosis (By similarity). May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity). | 0.732 |