node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ccl5 | Ccr1 | ENSRNOP00000014865 | ENSRNOP00000008772 | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | Macrophage inflammatory protein-1 alpha receptor; Belongs to the G-protein coupled receptor 1 family. | 0.999 |
Ccl5 | Ccr5 | ENSRNOP00000014865 | ENSRNOP00000073121 | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). | 0.999 |
Ccl5 | Ccr7 | ENSRNOP00000014865 | ENSRNOP00000014163 | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | Chemokine receptor 7-like protein; Belongs to the G-protein coupled receptor 1 family. | 0.968 |
Ccl5 | Ccr9 | ENSRNOP00000014865 | ENSRNOP00000008269 | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | Chemokine (C-C motif) receptor 9, isoform CRA_a; Belongs to the G-protein coupled receptor 1 family. | 0.886 |
Ccl5 | Cxcl10 | ENSRNOP00000014865 | ENSRNOP00000003649 | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...] | 0.995 |
Ccl5 | Cxcl12 | ENSRNOP00000014865 | ENSRNOP00000059574 | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | Stromal cell-derived factor-1 gamma; Belongs to the intercrine alpha (chemokine CxC) family. | 0.988 |
Ccl5 | Cxcl6 | ENSRNOP00000014865 | ENSRNOP00000003823 | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | C-X-C motif chemokine 5; May participate in the recruitment of inflammatory cells by injured or infected tissue. | 0.846 |
Ccl5 | Cxcl9 | ENSRNOP00000014865 | ENSRNOP00000003627 | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | C-X-C motif chemokine. | 0.995 |
Ccl5 | Xcl1 | ENSRNOP00000014865 | ENSRNOP00000003976 | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | Lymphotactin; Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment. Belongs to the intercrine gamma family. | 0.939 |
Ccl5 | Xcr1 | ENSRNOP00000014865 | ENSRNOP00000008747 | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | X-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. | 0.887 |
Ccr1 | Ccl5 | ENSRNOP00000008772 | ENSRNOP00000014865 | Macrophage inflammatory protein-1 alpha receptor; Belongs to the G-protein coupled receptor 1 family. | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | 0.999 |
Ccr1 | Ccr5 | ENSRNOP00000008772 | ENSRNOP00000073121 | Macrophage inflammatory protein-1 alpha receptor; Belongs to the G-protein coupled receptor 1 family. | C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). | 0.971 |
Ccr1 | Ccr7 | ENSRNOP00000008772 | ENSRNOP00000014163 | Macrophage inflammatory protein-1 alpha receptor; Belongs to the G-protein coupled receptor 1 family. | Chemokine receptor 7-like protein; Belongs to the G-protein coupled receptor 1 family. | 0.809 |
Ccr1 | Ccr9 | ENSRNOP00000008772 | ENSRNOP00000008269 | Macrophage inflammatory protein-1 alpha receptor; Belongs to the G-protein coupled receptor 1 family. | Chemokine (C-C motif) receptor 9, isoform CRA_a; Belongs to the G-protein coupled receptor 1 family. | 0.713 |
Ccr1 | Cxcl10 | ENSRNOP00000008772 | ENSRNOP00000003649 | Macrophage inflammatory protein-1 alpha receptor; Belongs to the G-protein coupled receptor 1 family. | C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...] | 0.983 |
Ccr1 | Cxcl12 | ENSRNOP00000008772 | ENSRNOP00000059574 | Macrophage inflammatory protein-1 alpha receptor; Belongs to the G-protein coupled receptor 1 family. | Stromal cell-derived factor-1 gamma; Belongs to the intercrine alpha (chemokine CxC) family. | 0.938 |
Ccr1 | Cxcl6 | ENSRNOP00000008772 | ENSRNOP00000003823 | Macrophage inflammatory protein-1 alpha receptor; Belongs to the G-protein coupled receptor 1 family. | C-X-C motif chemokine 5; May participate in the recruitment of inflammatory cells by injured or infected tissue. | 0.908 |
Ccr1 | Cxcl9 | ENSRNOP00000008772 | ENSRNOP00000003627 | Macrophage inflammatory protein-1 alpha receptor; Belongs to the G-protein coupled receptor 1 family. | C-X-C motif chemokine. | 0.933 |
Ccr1 | Xcl1 | ENSRNOP00000008772 | ENSRNOP00000003976 | Macrophage inflammatory protein-1 alpha receptor; Belongs to the G-protein coupled receptor 1 family. | Lymphotactin; Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment. Belongs to the intercrine gamma family. | 0.868 |
Ccr1 | Xcr1 | ENSRNOP00000008772 | ENSRNOP00000008747 | Macrophage inflammatory protein-1 alpha receptor; Belongs to the G-protein coupled receptor 1 family. | X-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. | 0.487 |