| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Abcc3 | Abcc4 | ENSRNOP00000003977 | ENSRNOP00000033826 | Canalicular multispecific organic anion transporter 2; May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). | ATP-binding cassette subfamily C member 4. | 0.917 |
| Abcc3 | Abcc5 | ENSRNOP00000003977 | ENSRNOP00000073913 | Canalicular multispecific organic anion transporter 2; May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). | Multidrug resistance-associated protein 5; Acts as a multispecific organic anion pump which can transport nucleotide analogs; Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. | 0.920 |
| Abcc3 | Cyp7a1 | ENSRNOP00000003977 | ENSRNOP00000012819 | Canalicular multispecific organic anion transporter 2; May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). | Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis. Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha position of cholesterol, a rate-limiting st [...] | 0.697 |
| Abcc3 | Slc10a1 | ENSRNOP00000003977 | ENSRNOP00000007825 | Canalicular multispecific organic anion transporter 2; May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). | Sodium/bile acid cotransporter; The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium. | 0.754 |
| Abcc3 | Slc22a7 | ENSRNOP00000003977 | ENSRNOP00000025094 | Canalicular multispecific organic anion transporter 2; May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). | Solute carrier family 22 member 7; Mediates sodium-independent multispecific organic anion transport. Transport of ketoprofen, indomethacin, salicylate, acetylsalicylate, prostaglandin E2, 3'-azido-3'-deoxythymidine (AZT), 2',3'-dideoxycytidine (ddC), dicarboxylates and p-aminohippurate (PAH). Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. | 0.700 |
| Abcc3 | Slc51a | ENSRNOP00000003977 | ENSRNOP00000002405 | Canalicular multispecific organic anion transporter 2; May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). | Similar to RIKEN cDNA D630035O19 (Predicted), isoform CRA_b. | 0.697 |
| Abcc3 | Slco1a1 | ENSRNOP00000003977 | ENSRNOP00000040752 | Canalicular multispecific organic anion transporter 2; May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). | Solute carrier organic anion transporter family member 1A1; Mediates the Na(+)-independent transport of organic anions such as bromosulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids. | 0.741 |
| Abcc3 | Slco1a2 | ENSRNOP00000003977 | ENSRNOP00000040237 | Canalicular multispecific organic anion transporter 2; May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). | Solute carrier organic anion transporter family member 1A4; Mediates the Na(+)-independent transport of organic anions such as taurocholate, cholate, 17-beta-glucuronosyl estradiol, estrone- 3-sulfate, the cardiac glycosides ouabain and digoxin and thyroid hormones. May play an especially important role in the brain accumulation and toxicity of digoxin and in the hepatobiliary and renal excretion of cardiac glycosides. | 0.744 |
| Abcc3 | Slco2b1 | ENSRNOP00000003977 | ENSRNOP00000024281 | Canalicular multispecific organic anion transporter 2; May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). | Solute carrier organic anion transporter family member 2B1; Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost. | 0.698 |
| Abcc3 | Ugt1a1 | ENSRNOP00000003977 | ENSRNOP00000025045 | Canalicular multispecific organic anion transporter 2; May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). | UDP-glucuronosyltransferase 1-1; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Glucuronates opioids and bilirubin; Belongs to the UDP-glycosyltransferase family. | 0.703 |
| Abcc4 | Abcc3 | ENSRNOP00000033826 | ENSRNOP00000003977 | ATP-binding cassette subfamily C member 4. | Canalicular multispecific organic anion transporter 2; May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). | 0.917 |
| Abcc4 | Abcc5 | ENSRNOP00000033826 | ENSRNOP00000073913 | ATP-binding cassette subfamily C member 4. | Multidrug resistance-associated protein 5; Acts as a multispecific organic anion pump which can transport nucleotide analogs; Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. | 0.900 |
| Abcc4 | Cyp7a1 | ENSRNOP00000033826 | ENSRNOP00000012819 | ATP-binding cassette subfamily C member 4. | Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis. Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha position of cholesterol, a rate-limiting st [...] | 0.556 |
| Abcc4 | Slc10a1 | ENSRNOP00000033826 | ENSRNOP00000007825 | ATP-binding cassette subfamily C member 4. | Sodium/bile acid cotransporter; The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium. | 0.695 |
| Abcc4 | Slc22a7 | ENSRNOP00000033826 | ENSRNOP00000025094 | ATP-binding cassette subfamily C member 4. | Solute carrier family 22 member 7; Mediates sodium-independent multispecific organic anion transport. Transport of ketoprofen, indomethacin, salicylate, acetylsalicylate, prostaglandin E2, 3'-azido-3'-deoxythymidine (AZT), 2',3'-dideoxycytidine (ddC), dicarboxylates and p-aminohippurate (PAH). Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. | 0.686 |
| Abcc4 | Slc51a | ENSRNOP00000033826 | ENSRNOP00000002405 | ATP-binding cassette subfamily C member 4. | Similar to RIKEN cDNA D630035O19 (Predicted), isoform CRA_b. | 0.616 |
| Abcc4 | Slco1a1 | ENSRNOP00000033826 | ENSRNOP00000040752 | ATP-binding cassette subfamily C member 4. | Solute carrier organic anion transporter family member 1A1; Mediates the Na(+)-independent transport of organic anions such as bromosulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids. | 0.633 |
| Abcc4 | Slco1a2 | ENSRNOP00000033826 | ENSRNOP00000040237 | ATP-binding cassette subfamily C member 4. | Solute carrier organic anion transporter family member 1A4; Mediates the Na(+)-independent transport of organic anions such as taurocholate, cholate, 17-beta-glucuronosyl estradiol, estrone- 3-sulfate, the cardiac glycosides ouabain and digoxin and thyroid hormones. May play an especially important role in the brain accumulation and toxicity of digoxin and in the hepatobiliary and renal excretion of cardiac glycosides. | 0.643 |
| Abcc4 | Slco2b1 | ENSRNOP00000033826 | ENSRNOP00000024281 | ATP-binding cassette subfamily C member 4. | Solute carrier organic anion transporter family member 2B1; Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost. | 0.700 |
| Abcc4 | Ugt1a1 | ENSRNOP00000033826 | ENSRNOP00000025045 | ATP-binding cassette subfamily C member 4. | UDP-glucuronosyltransferase 1-1; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Glucuronates opioids and bilirubin; Belongs to the UDP-glycosyltransferase family. | 0.444 |
