node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Bud31 | Cdc40 | ENSRNOP00000001307 | ENSRNOP00000071389 | Protein BUD31 homolog; Involved in the pre-mRNA splicing process. May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity; Belongs to the BUD31 (G10) family. | Cell division cycle 40. | 0.991 |
Bud31 | Cdc5l | ENSRNOP00000001307 | ENSRNOP00000027264 | Protein BUD31 homolog; Involved in the pre-mRNA splicing process. May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity; Belongs to the BUD31 (G10) family. | Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). | 0.994 |
Bud31 | Eftud2 | ENSRNOP00000001307 | ENSRNOP00000052049 | Protein BUD31 homolog; Involved in the pre-mRNA splicing process. May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity; Belongs to the BUD31 (G10) family. | Elongation factor Tu GTP-binding domain-containing 2. | 0.993 |
Bud31 | Prkrip1 | ENSRNOP00000001307 | ENSRNOP00000001937 | Protein BUD31 homolog; Involved in the pre-mRNA splicing process. May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity; Belongs to the BUD31 (G10) family. | Similar to PRKR interacting protein 1 (IL11 inducible). | 0.570 |
Bud31 | Prpf19 | ENSRNOP00000001307 | ENSRNOP00000028373 | Protein BUD31 homolog; Involved in the pre-mRNA splicing process. May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity; Belongs to the BUD31 (G10) family. | Pre-mRNA-processing factor 19; Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and [...] | 0.991 |
Bud31 | Sde2 | ENSRNOP00000001307 | ENSRNOP00000075283 | Protein BUD31 homolog; Involved in the pre-mRNA splicing process. May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity; Belongs to the BUD31 (G10) family. | Replication stress response regulator SDE2; Involved in both DNA replication and cell cycle control. Unprocessed SDE2 interacts with PCNA via its PIP-box. The interaction with PCNA prevents monoubiquitination of the latter thereby inhibiting translesion DNA synthesis. The binding of SDE2 to PCNA also leads to processing of SDE2 by an unidentified deubiquitinating enzyme, cleaving off the N-terminal ubiquitin-like domain. The resulting mature SDE2 is degraded by the DCX(DTL) complex in a cell cycle- and DNA damage dependent manner. Binding of SDE2 to PCNA is necessary to counteract dama [...] | 0.781 |
Bud31 | Slu7 | ENSRNOP00000001307 | ENSRNOP00000005132 | Protein BUD31 homolog; Involved in the pre-mRNA splicing process. May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity; Belongs to the BUD31 (G10) family. | Pre-mRNA-splicing factor SLU7; Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. Belongs to the SLU7 family. | 0.980 |
Bud31 | Snrnp200 | ENSRNOP00000001307 | ENSRNOP00000048598 | Protein BUD31 homolog; Involved in the pre-mRNA splicing process. May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity; Belongs to the BUD31 (G10) family. | U5 small nuclear ribonucleoprotein 200 kDa helicase; Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome. | 0.968 |
Bud31 | Snrnp40 | ENSRNOP00000001307 | ENSRNOP00000016325 | Protein BUD31 homolog; Involved in the pre-mRNA splicing process. May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity; Belongs to the BUD31 (G10) family. | Small nuclear ribonucleoprotein U5 subunit 40. | 0.983 |
Bud31 | Snrpa1 | ENSRNOP00000001307 | ENSRNOP00000016758 | Protein BUD31 homolog; Involved in the pre-mRNA splicing process. May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity; Belongs to the BUD31 (G10) family. | Small nuclear ribonucleoprotein polypeptide A. | 0.990 |
Cdc40 | Bud31 | ENSRNOP00000071389 | ENSRNOP00000001307 | Cell division cycle 40. | Protein BUD31 homolog; Involved in the pre-mRNA splicing process. May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity; Belongs to the BUD31 (G10) family. | 0.991 |
Cdc40 | Cdc5l | ENSRNOP00000071389 | ENSRNOP00000027264 | Cell division cycle 40. | Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). | 0.994 |
Cdc40 | Eftud2 | ENSRNOP00000071389 | ENSRNOP00000052049 | Cell division cycle 40. | Elongation factor Tu GTP-binding domain-containing 2. | 0.992 |
Cdc40 | Prkrip1 | ENSRNOP00000071389 | ENSRNOP00000001937 | Cell division cycle 40. | Similar to PRKR interacting protein 1 (IL11 inducible). | 0.762 |
Cdc40 | Prpf19 | ENSRNOP00000071389 | ENSRNOP00000028373 | Cell division cycle 40. | Pre-mRNA-processing factor 19; Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and [...] | 0.990 |
Cdc40 | Sde2 | ENSRNOP00000071389 | ENSRNOP00000075283 | Cell division cycle 40. | Replication stress response regulator SDE2; Involved in both DNA replication and cell cycle control. Unprocessed SDE2 interacts with PCNA via its PIP-box. The interaction with PCNA prevents monoubiquitination of the latter thereby inhibiting translesion DNA synthesis. The binding of SDE2 to PCNA also leads to processing of SDE2 by an unidentified deubiquitinating enzyme, cleaving off the N-terminal ubiquitin-like domain. The resulting mature SDE2 is degraded by the DCX(DTL) complex in a cell cycle- and DNA damage dependent manner. Binding of SDE2 to PCNA is necessary to counteract dama [...] | 0.819 |
Cdc40 | Slu7 | ENSRNOP00000071389 | ENSRNOP00000005132 | Cell division cycle 40. | Pre-mRNA-splicing factor SLU7; Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. Belongs to the SLU7 family. | 0.991 |
Cdc40 | Snrnp200 | ENSRNOP00000071389 | ENSRNOP00000048598 | Cell division cycle 40. | U5 small nuclear ribonucleoprotein 200 kDa helicase; Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome. | 0.977 |
Cdc40 | Snrnp40 | ENSRNOP00000071389 | ENSRNOP00000016325 | Cell division cycle 40. | Small nuclear ribonucleoprotein U5 subunit 40. | 0.986 |
Cdc40 | Snrpa1 | ENSRNOP00000071389 | ENSRNOP00000016758 | Cell division cycle 40. | Small nuclear ribonucleoprotein polypeptide A. | 0.992 |