node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Flcn | Fnip1 | ENSRNOP00000004412 | ENSRNOP00000012671 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity). Belongs to the folliculin family. | UDENN FNIP1/2-type domain-containing protein. | 0.999 |
Flcn | Fnip2 | ENSRNOP00000004412 | ENSRNOP00000031096 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity). Belongs to the folliculin family. | Folliculin-interacting protein 2. | 0.999 |
Flcn | Lamtor1 | ENSRNOP00000004412 | ENSRNOP00000027150 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity). Belongs to the folliculin family. | Ragulator complex protein LAMTOR1; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulat [...] | 0.853 |
Flcn | Lamtor3 | ENSRNOP00000004412 | ENSRNOP00000014027 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity). Belongs to the folliculin family. | Ragulator complex protein LAMTOR3; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP k [...] | 0.844 |
Flcn | RragB | ENSRNOP00000004412 | ENSRNOP00000004235 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity). Belongs to the folliculin family. | Ras-related GTP-binding protein B; Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycle between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. | 0.989 |
Flcn | RragB-2 | ENSRNOP00000004412 | ENSRNOP00000066990 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity). Belongs to the folliculin family. | Ras-related GTP binding B. | 0.894 |
Flcn | Rraga | ENSRNOP00000004412 | ENSRNOP00000009225 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity). Belongs to the folliculin family. | Ras-related GTP-binding protein A; Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. Bel [...] | 0.987 |
Flcn | Rragc | ENSRNOP00000004412 | ENSRNOP00000023514 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity). Belongs to the folliculin family. | Ras-related GTP-binding C. | 0.994 |
Flcn | Rragd | ENSRNOP00000004412 | ENSRNOP00000061453 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity). Belongs to the folliculin family. | Ras-related GTP binding D (Predicted), isoform CRA_b. | 0.987 |
Flcn | Slc38a9 | ENSRNOP00000004412 | ENSRNOP00000013218 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity). Belongs to the folliculin family. | Sodium-coupled neutral amino acid transporter 9; Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. SLC38A9 mediates transport of a [...] | 0.886 |
Fnip1 | Flcn | ENSRNOP00000012671 | ENSRNOP00000004412 | UDENN FNIP1/2-type domain-containing protein. | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity). Belongs to the folliculin family. | 0.999 |
Fnip1 | Fnip2 | ENSRNOP00000012671 | ENSRNOP00000031096 | UDENN FNIP1/2-type domain-containing protein. | Folliculin-interacting protein 2. | 0.982 |
Fnip1 | RragB | ENSRNOP00000012671 | ENSRNOP00000004235 | UDENN FNIP1/2-type domain-containing protein. | Ras-related GTP-binding protein B; Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycle between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. | 0.964 |
Fnip1 | RragB-2 | ENSRNOP00000012671 | ENSRNOP00000066990 | UDENN FNIP1/2-type domain-containing protein. | Ras-related GTP binding B. | 0.656 |
Fnip1 | Rraga | ENSRNOP00000012671 | ENSRNOP00000009225 | UDENN FNIP1/2-type domain-containing protein. | Ras-related GTP-binding protein A; Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. Bel [...] | 0.958 |
Fnip1 | Rragc | ENSRNOP00000012671 | ENSRNOP00000023514 | UDENN FNIP1/2-type domain-containing protein. | Ras-related GTP-binding C. | 0.964 |
Fnip1 | Rragd | ENSRNOP00000012671 | ENSRNOP00000061453 | UDENN FNIP1/2-type domain-containing protein. | Ras-related GTP binding D (Predicted), isoform CRA_b. | 0.961 |
Fnip1 | Slc38a9 | ENSRNOP00000012671 | ENSRNOP00000013218 | UDENN FNIP1/2-type domain-containing protein. | Sodium-coupled neutral amino acid transporter 9; Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. SLC38A9 mediates transport of a [...] | 0.469 |
Fnip2 | Flcn | ENSRNOP00000031096 | ENSRNOP00000004412 | Folliculin-interacting protein 2. | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity). Belongs to the folliculin family. | 0.999 |
Fnip2 | Fnip1 | ENSRNOP00000031096 | ENSRNOP00000012671 | Folliculin-interacting protein 2. | UDENN FNIP1/2-type domain-containing protein. | 0.982 |