Gulp1 protein (Rattus norvegicus) - STRING interaction network

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Gulp1

PTB domain-containing engulfment adapter protein 1; May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6 (By similarity). (304 aa)

Predicted Functional Partners:

Megf10

0.987

Megf11

0.969

Stab2

0.941

Stab1

0.928

Scarf1

0.918

Lrp1

0.887

Pear1

0.839

Rac2

0.835

Rac3

0.835

Lrp1b

0.816

Your Current Organism:

Rattus norvegicus

NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Gulp1	Lrp1	ENSRNOP00000004463	ENSRNOP00000034210	PTB domain-containing engulfment adapter protein 1; May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6 (By similarity).	Low-density lipoprotein receptor-related protein 1 intracellular domain; Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2- macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotr [...]	0.887
Gulp1	Lrp1b	ENSRNOP00000004463	ENSRNOP00000047160	PTB domain-containing engulfment adapter protein 1; May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6 (By similarity).	Uncharacterized protein.	0.816
Gulp1	Megf10	ENSRNOP00000004463	ENSRNOP00000036049	PTB domain-containing engulfment adapter protein 1; May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6 (By similarity).	Multiple EGF-like domains 10.	0.987
Gulp1	Megf11	ENSRNOP00000004463	ENSRNOP00000044316	PTB domain-containing engulfment adapter protein 1; May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6 (By similarity).	Multiple EGF-like-domains 11.	0.969
Gulp1	Pear1	ENSRNOP00000004463	ENSRNOP00000019502	PTB domain-containing engulfment adapter protein 1; May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6 (By similarity).	Platelet endothelial aggregation receptor 1.	0.839
Gulp1	Rac2	ENSRNOP00000004463	ENSRNOP00000009994	PTB domain-containing engulfment adapter protein 1; May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6 (By similarity).	Ras-related C3 botulinum toxin substrate 2 (Rho family, small GTP binding protein Rac2).	0.835
Gulp1	Rac3	ENSRNOP00000004463	ENSRNOP00000064762	PTB domain-containing engulfment adapter protein 1; May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6 (By similarity).	Rac family small GTPase 3.	0.835
Gulp1	Scarf1	ENSRNOP00000004463	ENSRNOP00000073392	PTB domain-containing engulfment adapter protein 1; May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6 (By similarity).	Scavenger receptor class F, member 1.	0.918
Gulp1	Stab1	ENSRNOP00000004463	ENSRNOP00000025394	PTB domain-containing engulfment adapter protein 1; May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6 (By similarity).	Stabilin 1.	0.928
Gulp1	Stab2	ENSRNOP00000004463	ENSRNOP00000056294	PTB domain-containing engulfment adapter protein 1; May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6 (By similarity).	175 kDa stabilin-2; Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity o [...]	0.941
Lrp1	Gulp1	ENSRNOP00000034210	ENSRNOP00000004463	Low-density lipoprotein receptor-related protein 1 intracellular domain; Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2- macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotr [...]	PTB domain-containing engulfment adapter protein 1; May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6 (By similarity).	0.887
Lrp1b	Gulp1	ENSRNOP00000047160	ENSRNOP00000004463	Uncharacterized protein.	PTB domain-containing engulfment adapter protein 1; May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6 (By similarity).	0.816
Megf10	Gulp1	ENSRNOP00000036049	ENSRNOP00000004463	Multiple EGF-like domains 10.	PTB domain-containing engulfment adapter protein 1; May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6 (By similarity).	0.987
Megf10	Megf11	ENSRNOP00000036049	ENSRNOP00000044316	Multiple EGF-like domains 10.	Multiple EGF-like-domains 11.	0.886
Megf11	Gulp1	ENSRNOP00000044316	ENSRNOP00000004463	Multiple EGF-like-domains 11.	PTB domain-containing engulfment adapter protein 1; May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6 (By similarity).	0.969
Megf11	Megf10	ENSRNOP00000044316	ENSRNOP00000036049	Multiple EGF-like-domains 11.	Multiple EGF-like domains 10.	0.886
Pear1	Gulp1	ENSRNOP00000019502	ENSRNOP00000004463	Platelet endothelial aggregation receptor 1.	PTB domain-containing engulfment adapter protein 1; May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6 (By similarity).	0.839
Rac2	Gulp1	ENSRNOP00000009994	ENSRNOP00000004463	Ras-related C3 botulinum toxin substrate 2 (Rho family, small GTP binding protein Rac2).	PTB domain-containing engulfment adapter protein 1; May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6 (By similarity).	0.835
Rac2	Rac3	ENSRNOP00000009994	ENSRNOP00000064762	Ras-related C3 botulinum toxin substrate 2 (Rho family, small GTP binding protein Rac2).	Rac family small GTPase 3.	0.833
Rac3	Gulp1	ENSRNOP00000064762	ENSRNOP00000004463	Rac family small GTPase 3.	PTB domain-containing engulfment adapter protein 1; May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6 (By similarity).	0.835

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