STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Krt17Keratin, type I cytoskeletal 17; Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epit [...] (433 aa)    
Predicted Functional Partners:
Krt14
Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5- KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro.
  
 
0.663
Krt16
Type I keratin KA16; Belongs to the intermediate filament family.
  
 
0.654
Krt5
Keratin, type II cytoskeletal 5.
   
 
0.646
Lrig1
Leucine-rich repeats and immunoglobulin-like domains 1.
   
 
 0.569
LOC298795
Similar to 14-3-3 protein sigma; Belongs to the 14-3-3 family.
   
 
 0.547
Krt15
Keratin, type I cytoskeletal 15; Belongs to the intermediate filament family.
  
 
0.545
Sfn
Stratifin; Belongs to the 14-3-3 family.
   
 
 0.544
Krt36
Type I hair keratin KA31; Belongs to the intermediate filament family.
  
 
0.529
Krt13
Keratin, type I cytoskeletal 13.
  
 
0.518
Kprp
Keratinocyte proline-rich protein.
   
 
 0.513
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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