node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Kdsr | Sptlc1 | ENSRNOP00000003728 | ENSRNOP00000014546 | Follicular lymphoma variant translocation 1 (Predicted), isoform CRA_a; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Serine palmitoyltransferase 1; Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to [...] | 0.996 |
Kdsr | Sptlc2 | ENSRNOP00000003728 | ENSRNOP00000016324 | Follicular lymphoma variant translocation 1 (Predicted), isoform CRA_a; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Serine palmitoyltransferase 2; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate (By similarity). Plays an important role in de novo sphyngolipid biosynthesis which is crucial for adipogenesis (By similarity). | 0.990 |
Kdsr | Sptlc3 | ENSRNOP00000003728 | ENSRNOP00000005920 | Follicular lymphoma variant translocation 1 (Predicted), isoform CRA_a; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Serine palmitoyltransferase, long chain base subunit 3. | 0.990 |
Kdsr | Sptssa | ENSRNOP00000003728 | ENSRNOP00000005825 | Follicular lymphoma variant translocation 1 (Predicted), isoform CRA_a; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Serine palmitoyltransferase small subunit A; Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1- SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. Plays a role in MBOAT7 location to mitochondria-associated membranes (MAMs), may me involved in fatty acid remodeling phosphatidylinositol (PI). | 0.637 |
Ormdl1 | Ormdl2 | ENSRNOP00000061507 | ENSRNOP00000047680 | ORMDL sphingolipid biosynthesis regulator 1. | ORM1-like protein; Negative regulator of sphingolipid synthesis. | 0.621 |
Ormdl1 | Ormdl3 | ENSRNOP00000061507 | ENSRNOP00000046432 | ORMDL sphingolipid biosynthesis regulator 1. | ORM1-like protein 3; Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling (By similarity). | 0.591 |
Ormdl1 | Sptlc1 | ENSRNOP00000061507 | ENSRNOP00000014546 | ORMDL sphingolipid biosynthesis regulator 1. | Serine palmitoyltransferase 1; Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to [...] | 0.953 |
Ormdl1 | Sptlc2 | ENSRNOP00000061507 | ENSRNOP00000016324 | ORMDL sphingolipid biosynthesis regulator 1. | Serine palmitoyltransferase 2; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate (By similarity). Plays an important role in de novo sphyngolipid biosynthesis which is crucial for adipogenesis (By similarity). | 0.884 |
Ormdl1 | Sptlc3 | ENSRNOP00000061507 | ENSRNOP00000005920 | ORMDL sphingolipid biosynthesis regulator 1. | Serine palmitoyltransferase, long chain base subunit 3. | 0.884 |
Ormdl1 | Sptssa | ENSRNOP00000061507 | ENSRNOP00000005825 | ORMDL sphingolipid biosynthesis regulator 1. | Serine palmitoyltransferase small subunit A; Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1- SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. Plays a role in MBOAT7 location to mitochondria-associated membranes (MAMs), may me involved in fatty acid remodeling phosphatidylinositol (PI). | 0.913 |
Ormdl2 | Ormdl1 | ENSRNOP00000047680 | ENSRNOP00000061507 | ORM1-like protein; Negative regulator of sphingolipid synthesis. | ORMDL sphingolipid biosynthesis regulator 1. | 0.621 |
Ormdl2 | Ormdl3 | ENSRNOP00000047680 | ENSRNOP00000046432 | ORM1-like protein; Negative regulator of sphingolipid synthesis. | ORM1-like protein 3; Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling (By similarity). | 0.568 |
Ormdl2 | Sptlc1 | ENSRNOP00000047680 | ENSRNOP00000014546 | ORM1-like protein; Negative regulator of sphingolipid synthesis. | Serine palmitoyltransferase 1; Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to [...] | 0.945 |
Ormdl2 | Sptlc2 | ENSRNOP00000047680 | ENSRNOP00000016324 | ORM1-like protein; Negative regulator of sphingolipid synthesis. | Serine palmitoyltransferase 2; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate (By similarity). Plays an important role in de novo sphyngolipid biosynthesis which is crucial for adipogenesis (By similarity). | 0.868 |
Ormdl2 | Sptlc3 | ENSRNOP00000047680 | ENSRNOP00000005920 | ORM1-like protein; Negative regulator of sphingolipid synthesis. | Serine palmitoyltransferase, long chain base subunit 3. | 0.852 |
Ormdl2 | Sptssa | ENSRNOP00000047680 | ENSRNOP00000005825 | ORM1-like protein; Negative regulator of sphingolipid synthesis. | Serine palmitoyltransferase small subunit A; Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1- SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. Plays a role in MBOAT7 location to mitochondria-associated membranes (MAMs), may me involved in fatty acid remodeling phosphatidylinositol (PI). | 0.893 |
Ormdl3 | Ormdl1 | ENSRNOP00000046432 | ENSRNOP00000061507 | ORM1-like protein 3; Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling (By similarity). | ORMDL sphingolipid biosynthesis regulator 1. | 0.591 |
Ormdl3 | Ormdl2 | ENSRNOP00000046432 | ENSRNOP00000047680 | ORM1-like protein 3; Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling (By similarity). | ORM1-like protein; Negative regulator of sphingolipid synthesis. | 0.568 |
Ormdl3 | Sptlc1 | ENSRNOP00000046432 | ENSRNOP00000014546 | ORM1-like protein 3; Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling (By similarity). | Serine palmitoyltransferase 1; Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to [...] | 0.983 |
Ormdl3 | Sptlc2 | ENSRNOP00000046432 | ENSRNOP00000016324 | ORM1-like protein 3; Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling (By similarity). | Serine palmitoyltransferase 2; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate (By similarity). Plays an important role in de novo sphyngolipid biosynthesis which is crucial for adipogenesis (By similarity). | 0.957 |