Dcn protein (Rattus norvegicus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Rattus norvegicus

NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ccdc80	Col3a1	ENSRNOP00000056490	ENSRNOP00000004956	Coiled-coil domain-containing protein 80; Promotes cell adhesion and matrix assembly; Belongs to the CCDC80 family.	Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12 (By similarity).	0.628
Ccdc80	Dcn	ENSRNOP00000056490	ENSRNOP00000006070	Coiled-coil domain-containing protein 80; Promotes cell adhesion and matrix assembly; Belongs to the CCDC80 family.	Decorin; May affect the rate of fibrils formation (By similarity). May be implicated in the dilatation of the rat cervix.	0.998
Ccdc80	Igfbp7	ENSRNOP00000056490	ENSRNOP00000002809	Coiled-coil domain-containing protein 80; Promotes cell adhesion and matrix assembly; Belongs to the CCDC80 family.	Insulin-like growth factor binding protein 7, isoform CRA_b.	0.998
Ccdc80	Lum	ENSRNOP00000056490	ENSRNOP00000006109	Coiled-coil domain-containing protein 80; Promotes cell adhesion and matrix assembly; Belongs to the CCDC80 family.	Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.	0.414
Ccdc80	Sparc	ENSRNOP00000056490	ENSRNOP00000017486	Coiled-coil domain-containing protein 80; Promotes cell adhesion and matrix assembly; Belongs to the CCDC80 family.	SPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity; Belongs to the SPARC family.	0.478
Col3a1	Ccdc80	ENSRNOP00000004956	ENSRNOP00000056490	Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12 (By similarity).	Coiled-coil domain-containing protein 80; Promotes cell adhesion and matrix assembly; Belongs to the CCDC80 family.	0.628
Col3a1	Dcn	ENSRNOP00000004956	ENSRNOP00000006070	Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12 (By similarity).	Decorin; May affect the rate of fibrils formation (By similarity). May be implicated in the dilatation of the rat cervix.	0.972
Col3a1	Igf1	ENSRNOP00000004956	ENSRNOP00000073824	Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12 (By similarity).	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	0.480
Col3a1	Lum	ENSRNOP00000004956	ENSRNOP00000006109	Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12 (By similarity).	Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.	0.990
Col3a1	Sparc	ENSRNOP00000004956	ENSRNOP00000017486	Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12 (By similarity).	SPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity; Belongs to the SPARC family.	0.957
Col3a1	Tgfb1	ENSRNOP00000004956	ENSRNOP00000028051	Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12 (By similarity).	Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...]	0.675
Col3a1	Tgfb3	ENSRNOP00000004956	ENSRNOP00000013516	Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12 (By similarity).	Transforming growth factor beta-3 proprotein; Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi appa [...]	0.614
Dcn	Ccdc80	ENSRNOP00000006070	ENSRNOP00000056490	Decorin; May affect the rate of fibrils formation (By similarity). May be implicated in the dilatation of the rat cervix.	Coiled-coil domain-containing protein 80; Promotes cell adhesion and matrix assembly; Belongs to the CCDC80 family.	0.998
Dcn	Col3a1	ENSRNOP00000006070	ENSRNOP00000004956	Decorin; May affect the rate of fibrils formation (By similarity). May be implicated in the dilatation of the rat cervix.	Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12 (By similarity).	0.972
Dcn	Egfr	ENSRNOP00000006070	ENSRNOP00000006087	Decorin; May affect the rate of fibrils formation (By similarity). May be implicated in the dilatation of the rat cervix.	Receptor protein-tyrosine kinase.	0.969
Dcn	Igf1	ENSRNOP00000006070	ENSRNOP00000073824	Decorin; May affect the rate of fibrils formation (By similarity). May be implicated in the dilatation of the rat cervix.	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	0.947
Dcn	Igfbp7	ENSRNOP00000006070	ENSRNOP00000002809	Decorin; May affect the rate of fibrils formation (By similarity). May be implicated in the dilatation of the rat cervix.	Insulin-like growth factor binding protein 7, isoform CRA_b.	0.998
Dcn	Lum	ENSRNOP00000006070	ENSRNOP00000006109	Decorin; May affect the rate of fibrils formation (By similarity). May be implicated in the dilatation of the rat cervix.	Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.	0.969
Dcn	Sparc	ENSRNOP00000006070	ENSRNOP00000017486	Decorin; May affect the rate of fibrils formation (By similarity). May be implicated in the dilatation of the rat cervix.	SPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity; Belongs to the SPARC family.	0.953
Dcn	Tgfb1	ENSRNOP00000006070	ENSRNOP00000028051	Decorin; May affect the rate of fibrils formation (By similarity). May be implicated in the dilatation of the rat cervix.	Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...]	0.990

page 1 of 4

Server load: low (14%) [HD]

Share

Network

Co-occurrence

Experiments

Co-expression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2026

Credits

Access

Info

About