node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cd244 | Cd48 | ENSRNOP00000006266 | ENSRNOP00000006306 | Natural killer cell receptor 2B4; Modulate other receptor-ligand interactions to enhance leukocyte activation. | CD48 antigen; Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation. | 0.999 |
Cd244 | Fyn | ENSRNOP00000006266 | ENSRNOP00000000733 | Natural killer cell receptor 2B4; Modulate other receptor-ligand interactions to enhance leukocyte activation. | Tyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through [...] | 0.961 |
Cd244 | Lat | ENSRNOP00000006266 | ENSRNOP00000023563 | Natural killer cell receptor 2B4; Modulate other receptor-ligand interactions to enhance leukocyte activation. | Linker for activation of T-cells family member 1; Required for TCR (T-cell antigen receptor)- and pre-TCR- mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeleta [...] | 0.920 |
Cd244 | Ncr1 | ENSRNOP00000006266 | ENSRNOP00000025080 | Natural killer cell receptor 2B4; Modulate other receptor-ligand interactions to enhance leukocyte activation. | Natural cytotoxicity triggering receptor 1; Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. | 0.817 |
Cd244 | Sh2d1a | ENSRNOP00000006266 | ENSRNOP00000008444 | Natural killer cell receptor 2B4; Modulate other receptor-ligand interactions to enhance leukocyte activation. | SH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1. Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Ca [...] | 0.993 |
Cd244 | Sh2d1b | ENSRNOP00000006266 | ENSRNOP00000047078 | Natural killer cell receptor 2B4; Modulate other receptor-ligand interactions to enhance leukocyte activation. | SH2 domain-containing 1B. | 0.947 |
Cd244 | Sh2d1b2 | ENSRNOP00000006266 | ENSRNOP00000055346 | Natural killer cell receptor 2B4; Modulate other receptor-ligand interactions to enhance leukocyte activation. | SH2 domain-containing 1B2. | 0.948 |
Cd244 | Slamf6 | ENSRNOP00000006266 | ENSRNOP00000035388 | Natural killer cell receptor 2B4; Modulate other receptor-ligand interactions to enhance leukocyte activation. | SLAM family member 6. | 0.878 |
Cd244 | Slamf7 | ENSRNOP00000006266 | ENSRNOP00000038176 | Natural killer cell receptor 2B4; Modulate other receptor-ligand interactions to enhance leukocyte activation. | Similar to SLAM family member 7 (Predicted), isoform CRA_a. | 0.839 |
Cd244 | Slamf8 | ENSRNOP00000006266 | ENSRNOP00000011869 | Natural killer cell receptor 2B4; Modulate other receptor-ligand interactions to enhance leukocyte activation. | SLAM family member 8 (Predicted). | 0.812 |
Cd48 | Cd244 | ENSRNOP00000006306 | ENSRNOP00000006266 | CD48 antigen; Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation. | Natural killer cell receptor 2B4; Modulate other receptor-ligand interactions to enhance leukocyte activation. | 0.999 |
Cd48 | Fyn | ENSRNOP00000006306 | ENSRNOP00000000733 | CD48 antigen; Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation. | Tyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through [...] | 0.565 |
Cd48 | Ncr1 | ENSRNOP00000006306 | ENSRNOP00000025080 | CD48 antigen; Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation. | Natural cytotoxicity triggering receptor 1; Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. | 0.582 |
Cd48 | Sh2d1a | ENSRNOP00000006306 | ENSRNOP00000008444 | CD48 antigen; Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation. | SH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1. Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Ca [...] | 0.768 |
Cd48 | Sh2d1b2 | ENSRNOP00000006306 | ENSRNOP00000055346 | CD48 antigen; Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation. | SH2 domain-containing 1B2. | 0.597 |
Cd48 | Slamf6 | ENSRNOP00000006306 | ENSRNOP00000035388 | CD48 antigen; Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation. | SLAM family member 6. | 0.770 |
Cd48 | Slamf7 | ENSRNOP00000006306 | ENSRNOP00000038176 | CD48 antigen; Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation. | Similar to SLAM family member 7 (Predicted), isoform CRA_a. | 0.612 |
Fyn | Cd244 | ENSRNOP00000000733 | ENSRNOP00000006266 | Tyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through [...] | Natural killer cell receptor 2B4; Modulate other receptor-ligand interactions to enhance leukocyte activation. | 0.961 |
Fyn | Cd48 | ENSRNOP00000000733 | ENSRNOP00000006306 | Tyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through [...] | CD48 antigen; Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation. | 0.565 |
Fyn | Lat | ENSRNOP00000000733 | ENSRNOP00000023563 | Tyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through [...] | Linker for activation of T-cells family member 1; Required for TCR (T-cell antigen receptor)- and pre-TCR- mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeleta [...] | 0.819 |