node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Itga4 | Itga5 | ENSRNOP00000006880 | ENSRNOP00000071805 | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | Integrin alpha 5 (Mapped); Belongs to the integrin alpha chain family. | 0.964 |
Itga4 | Itgb1 | ENSRNOP00000006880 | ENSRNOP00000014785 | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] | 0.999 |
Itga4 | Itgb2 | ENSRNOP00000006880 | ENSRNOP00000001639 | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | Integrin beta. | 0.980 |
Itga4 | Itgb3 | ENSRNOP00000006880 | ENSRNOP00000067271 | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | Integrin beta-3; Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIB/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIB/beta-3 and alpha- V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIB/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A- G-D-V in fibrinogen gamma chain. Following ac [...] | 0.963 |
Itga4 | Itgb7 | ENSRNOP00000006880 | ENSRNOP00000016642 | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | Integrin beta; Belongs to the integrin beta chain family. | 0.999 |
Itga4 | Jam2 | ENSRNOP00000006880 | ENSRNOP00000049564 | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | Junctional adhesion molecule 2. | 0.944 |
Itga4 | Pxn | ENSRNOP00000006880 | ENSRNOP00000043928 | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. | 0.995 |
Itga4 | Src | ENSRNOP00000006880 | ENSRNOP00000071837 | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | Proto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] | 0.942 |
Itga4 | Tspan8 | ENSRNOP00000006880 | ENSRNOP00000005909 | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | Tetraspanin. | 0.967 |
Itga4 | Vcam1 | ENSRNOP00000006880 | ENSRNOP00000071423 | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | Vascular cell adhesion protein 1; Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha- 4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. | 0.999 |
Itga5 | Itga4 | ENSRNOP00000071805 | ENSRNOP00000006880 | Integrin alpha 5 (Mapped); Belongs to the integrin alpha chain family. | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | 0.964 |
Itga5 | Itgb1 | ENSRNOP00000071805 | ENSRNOP00000014785 | Integrin alpha 5 (Mapped); Belongs to the integrin alpha chain family. | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] | 0.999 |
Itga5 | Itgb2 | ENSRNOP00000071805 | ENSRNOP00000001639 | Integrin alpha 5 (Mapped); Belongs to the integrin alpha chain family. | Integrin beta. | 0.978 |
Itga5 | Itgb3 | ENSRNOP00000071805 | ENSRNOP00000067271 | Integrin alpha 5 (Mapped); Belongs to the integrin alpha chain family. | Integrin beta-3; Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIB/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIB/beta-3 and alpha- V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIB/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A- G-D-V in fibrinogen gamma chain. Following ac [...] | 0.996 |
Itga5 | Itgb7 | ENSRNOP00000071805 | ENSRNOP00000016642 | Integrin alpha 5 (Mapped); Belongs to the integrin alpha chain family. | Integrin beta; Belongs to the integrin beta chain family. | 0.983 |
Itga5 | Pxn | ENSRNOP00000071805 | ENSRNOP00000043928 | Integrin alpha 5 (Mapped); Belongs to the integrin alpha chain family. | Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. | 0.974 |
Itga5 | Src | ENSRNOP00000071805 | ENSRNOP00000071837 | Integrin alpha 5 (Mapped); Belongs to the integrin alpha chain family. | Proto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] | 0.943 |
Itga5 | Vcam1 | ENSRNOP00000071805 | ENSRNOP00000071423 | Integrin alpha 5 (Mapped); Belongs to the integrin alpha chain family. | Vascular cell adhesion protein 1; Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha- 4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. | 0.667 |
Itgb1 | Itga4 | ENSRNOP00000014785 | ENSRNOP00000006880 | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | 0.999 |
Itgb1 | Itga5 | ENSRNOP00000014785 | ENSRNOP00000071805 | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] | Integrin alpha 5 (Mapped); Belongs to the integrin alpha chain family. | 0.999 |