Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
IGHG1_RATIg gamma-1 chain C region. (326 aa)    
Predicted Functional Partners:
Igll1
Immunoglobulin lambda-like polypeptide 1.
   
 
0.967
IgL
Ig lambda-2 chain C region.
   
 
0.911
Igh-1a
Ig gamma-2B chain C region.
  
 
0.909
LOC100361706
Ig lambda-1 chain C region.
   
 
 
0.906
Jchain
Immunoglobulin joining chain.
   
 0.901
Fcgr2b
Low affinity immunoglobulin gamma Fc region receptor II; Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens.
   
 0.854
Cd79a
Ig-like domain-containing protein.
   
 
 0.812
Cd79b
B29/Ig-beta/CD79b.
   
 
 0.796
Pigr
Polymeric immunoglobulin receptor; This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.
    
 0.795
Vpreb1
V-set pre-B cell surrogate light chain 1.
    
 0.781
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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