node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Agmat | Aoc1 | ENSRNOP00000016646 | ENSRNOP00000055909 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. | 0.957 |
Agmat | Arg1 | ENSRNOP00000016646 | ENSRNOP00000017911 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | Arginase-1; Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. | 0.540 |
Agmat | Arg2 | ENSRNOP00000016646 | ENSRNOP00000073568 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | Arginase-2, mitochondrial; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated T cells. May suppress inflammation-related signaling in asthmatic airway epithelium. May play a role in promoting prenatal immune suppression. Regulates RPS6KB1 signal [...] | 0.541 |
Agmat | Doxl1 | ENSRNOP00000016646 | ENSRNOP00000033821 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | Amine oxidase. | 0.957 |
Agmat | Doxl2 | ENSRNOP00000016646 | ENSRNOP00000048618 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | Amine oxidase; Belongs to the copper/topaquinone oxidase family. | 0.957 |
Agmat | Oat | ENSRNOP00000016646 | ENSRNOP00000022628 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | Ornithine aminotransferase, mitochondrial. | 0.937 |
Agmat | Odc1 | ENSRNOP00000016646 | ENSRNOP00000007259 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | Ornithine decarboxylase; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. Belongs to the Orn/Lys/Arg decarboxylase class-II family. | 0.986 |
Agmat | Sat1 | ENSRNOP00000016646 | ENSRNOP00000068531 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | Spermidine/spermine N1-acetyl transferase 1. | 0.944 |
Agmat | Srm | ENSRNOP00000016646 | ENSRNOP00000014934 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | Spermidine synthase; Belongs to the spermidine/spermine synthase family. | 0.986 |
Aoc1 | Agmat | ENSRNOP00000055909 | ENSRNOP00000016646 | Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | 0.957 |
Aoc1 | Doxl1 | ENSRNOP00000055909 | ENSRNOP00000033821 | Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. | Amine oxidase. | 0.904 |
Aoc1 | Doxl2 | ENSRNOP00000055909 | ENSRNOP00000048618 | Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. | Amine oxidase; Belongs to the copper/topaquinone oxidase family. | 0.903 |
Aoc1 | Odc1 | ENSRNOP00000055909 | ENSRNOP00000007259 | Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. | Ornithine decarboxylase; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. Belongs to the Orn/Lys/Arg decarboxylase class-II family. | 0.966 |
Aoc1 | Sat1 | ENSRNOP00000055909 | ENSRNOP00000068531 | Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. | Spermidine/spermine N1-acetyl transferase 1. | 0.921 |
Aoc1 | Srm | ENSRNOP00000055909 | ENSRNOP00000014934 | Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. | Spermidine synthase; Belongs to the spermidine/spermine synthase family. | 0.935 |
Arg1 | Agmat | ENSRNOP00000017911 | ENSRNOP00000016646 | Arginase-1; Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | 0.540 |
Arg1 | Arg2 | ENSRNOP00000017911 | ENSRNOP00000073568 | Arginase-1; Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. | Arginase-2, mitochondrial; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated T cells. May suppress inflammation-related signaling in asthmatic airway epithelium. May play a role in promoting prenatal immune suppression. Regulates RPS6KB1 signal [...] | 0.910 |
Arg1 | Oat | ENSRNOP00000017911 | ENSRNOP00000022628 | Arginase-1; Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. | Ornithine aminotransferase, mitochondrial. | 0.997 |
Arg1 | Odc1 | ENSRNOP00000017911 | ENSRNOP00000007259 | Arginase-1; Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. | Ornithine decarboxylase; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. Belongs to the Orn/Lys/Arg decarboxylase class-II family. | 0.984 |
Arg1 | Srm | ENSRNOP00000017911 | ENSRNOP00000014934 | Arginase-1; Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. | Spermidine synthase; Belongs to the spermidine/spermine synthase family. | 0.827 |