Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Birc2 | Birc3 | ENSRNOP00000014560 | ENSRNOP00000007702 | Baculoviral IAP repeat-containing 2. | Baculoviral IAP repeat-containing 3. | 0.983 |
| Birc2 | Ikbkg | ENSRNOP00000014560 | ENSRNOP00000075158 | Baculoviral IAP repeat-containing 2. | NF-kappa-B essential modulator; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. Also considered to be a mediator for TAX activation of NF- kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral [...] | 0.909 |
| Birc2 | LOC100910771 | ENSRNOP00000014560 | ENSRNOP00000007657 | Baculoviral IAP repeat-containing 2. | Mitogen activated protein kinase kinase kinase 7. | 0.980 |
| Birc2 | Myd88 | ENSRNOP00000014560 | ENSRNOP00000018341 | Baculoviral IAP repeat-containing 2. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] | 0.908 |
| Birc2 | Tab1 | ENSRNOP00000014560 | ENSRNOP00000075816 | Baculoviral IAP repeat-containing 2. | TGF-beta-activated kinase 1/MAP3K7-binding protein 1. | 0.872 |
| Birc2 | Tab2 | ENSRNOP00000014560 | ENSRNOP00000021904 | Baculoviral IAP repeat-containing 2. | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Regulates the IL1-mediated translocation of NCOR1 out of the nucleus (By similarity). Involved in heart development (By similarity). | 0.859 |
| Birc2 | Tlr4 | ENSRNOP00000014560 | ENSRNOP00000014020 | Baculoviral IAP repeat-containing 2. | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] | 0.983 |
| Birc2 | Traf6 | ENSRNOP00000014560 | ENSRNOP00000006148 | Baculoviral IAP repeat-containing 2. | TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] | 0.962 |
| Birc2 | Ube2n | ENSRNOP00000014560 | ENSRNOP00000071283 | Baculoviral IAP repeat-containing 2. | Ubiquitin-conjugating enzyme E2 N; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly- ubiquitination of [...] | 0.917 |
| Birc3 | Birc2 | ENSRNOP00000007702 | ENSRNOP00000014560 | Baculoviral IAP repeat-containing 3. | Baculoviral IAP repeat-containing 2. | 0.983 |
| Birc3 | Ikbkg | ENSRNOP00000007702 | ENSRNOP00000075158 | Baculoviral IAP repeat-containing 3. | NF-kappa-B essential modulator; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. Also considered to be a mediator for TAX activation of NF- kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral [...] | 0.910 |
| Birc3 | LOC100910771 | ENSRNOP00000007702 | ENSRNOP00000007657 | Baculoviral IAP repeat-containing 3. | Mitogen activated protein kinase kinase kinase 7. | 0.980 |
| Birc3 | Myd88 | ENSRNOP00000007702 | ENSRNOP00000018341 | Baculoviral IAP repeat-containing 3. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] | 0.993 |
| Birc3 | Tab1 | ENSRNOP00000007702 | ENSRNOP00000075816 | Baculoviral IAP repeat-containing 3. | TGF-beta-activated kinase 1/MAP3K7-binding protein 1. | 0.851 |
| Birc3 | Tab2 | ENSRNOP00000007702 | ENSRNOP00000021904 | Baculoviral IAP repeat-containing 3. | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Regulates the IL1-mediated translocation of NCOR1 out of the nucleus (By similarity). Involved in heart development (By similarity). | 0.859 |
| Birc3 | Tlr4 | ENSRNOP00000007702 | ENSRNOP00000014020 | Baculoviral IAP repeat-containing 3. | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] | 0.984 |
| Birc3 | Traf6 | ENSRNOP00000007702 | ENSRNOP00000006148 | Baculoviral IAP repeat-containing 3. | TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] | 0.932 |
| Birc3 | Ube2n | ENSRNOP00000007702 | ENSRNOP00000071283 | Baculoviral IAP repeat-containing 3. | Ubiquitin-conjugating enzyme E2 N; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly- ubiquitination of [...] | 0.924 |
| Ikbkg | Birc2 | ENSRNOP00000075158 | ENSRNOP00000014560 | NF-kappa-B essential modulator; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. Also considered to be a mediator for TAX activation of NF- kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral [...] | Baculoviral IAP repeat-containing 2. | 0.909 |
| Ikbkg | Birc3 | ENSRNOP00000075158 | ENSRNOP00000007702 | NF-kappa-B essential modulator; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. Also considered to be a mediator for TAX activation of NF- kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral [...] | Baculoviral IAP repeat-containing 3. | 0.910 |
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