| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Avp | Cck | ENSRNOP00000028833 | ENSRNOP00000026159 | Vasopressin-neurophysin 2-copeptin; Neurophysin 2 specifically binds vasopressin; Belongs to the vasopressin/oxytocin family | Cholecystokinin; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion; Belongs to the gastrin/cholecystokinin family | 0.954 |
| Avp | Gnaq | ENSRNOP00000028833 | ENSRNOP00000019174 | Vasopressin-neurophysin 2-copeptin; Neurophysin 2 specifically binds vasopressin; Belongs to the vasopressin/oxytocin family | Guanine nucleotide-binding protein G(q) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems | 0.906 |
| Avp | Gnrh1 | ENSRNOP00000028833 | ENSRNOP00000018006 | Vasopressin-neurophysin 2-copeptin; Neurophysin 2 specifically binds vasopressin; Belongs to the vasopressin/oxytocin family | Progonadoliberin-1; Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones | 0.964 |
| Avp | Hcrt | ENSRNOP00000028833 | ENSRNOP00000025547 | Vasopressin-neurophysin 2-copeptin; Neurophysin 2 specifically binds vasopressin; Belongs to the vasopressin/oxytocin family | Orexin; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. A modulation effect on luteinizing hormone-releasing hormone (LHRH) secretion also suggests a more minor contribution to the regulation of reproductive function. Orexin-A binds to both OX1R and OX2R with a h [...] | 0.953 |
| Avp | Nps | ENSRNOP00000028833 | ENSRNOP00000051780 | Vasopressin-neurophysin 2-copeptin; Neurophysin 2 specifically binds vasopressin; Belongs to the vasopressin/oxytocin family | Neuropeptide S; May play an important anorexigenic role. Modulates arousal and anxiety as well as increases locomotor activity. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations | 0.972 |
| Avp | Nts | ENSRNOP00000028833 | ENSRNOP00000005706 | Vasopressin-neurophysin 2-copeptin; Neurophysin 2 specifically binds vasopressin; Belongs to the vasopressin/oxytocin family | Neurotensin/neuromedin N; Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle | 0.951 |
| Avp | Oxt | ENSRNOP00000028833 | ENSRNOP00000028829 | Vasopressin-neurophysin 2-copeptin; Neurophysin 2 specifically binds vasopressin; Belongs to the vasopressin/oxytocin family | Oxytocin-neurophysin 1; Neurophysin 1 specifically binds oxytocin | 0.977 |
| Avp | Oxtr | ENSRNOP00000028833 | ENSRNOP00000007724 | Vasopressin-neurophysin 2-copeptin; Neurophysin 2 specifically binds vasopressin; Belongs to the vasopressin/oxytocin family | Oxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol- calcium second messenger system | 0.980 |
| Avp | Ptgfr | ENSRNOP00000028833 | ENSRNOP00000065253 | Vasopressin-neurophysin 2-copeptin; Neurophysin 2 specifically binds vasopressin; Belongs to the vasopressin/oxytocin family | Prostaglandin F2-alpha receptor; Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum | 0.905 |
| Avp | Trh | ENSRNOP00000028833 | ENSRNOP00000015944 | Vasopressin-neurophysin 2-copeptin; Neurophysin 2 specifically binds vasopressin; Belongs to the vasopressin/oxytocin family | Pro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems | 0.963 |
| Cck | Avp | ENSRNOP00000026159 | ENSRNOP00000028833 | Cholecystokinin; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion; Belongs to the gastrin/cholecystokinin family | Vasopressin-neurophysin 2-copeptin; Neurophysin 2 specifically binds vasopressin; Belongs to the vasopressin/oxytocin family | 0.954 |
| Cck | Gnaq | ENSRNOP00000026159 | ENSRNOP00000019174 | Cholecystokinin; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion; Belongs to the gastrin/cholecystokinin family | Guanine nucleotide-binding protein G(q) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems | 0.919 |
| Cck | Gnrh1 | ENSRNOP00000026159 | ENSRNOP00000018006 | Cholecystokinin; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion; Belongs to the gastrin/cholecystokinin family | Progonadoliberin-1; Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones | 0.951 |
| Cck | Hcrt | ENSRNOP00000026159 | ENSRNOP00000025547 | Cholecystokinin; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion; Belongs to the gastrin/cholecystokinin family | Orexin; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. A modulation effect on luteinizing hormone-releasing hormone (LHRH) secretion also suggests a more minor contribution to the regulation of reproductive function. Orexin-A binds to both OX1R and OX2R with a h [...] | 0.970 |
| Cck | Nps | ENSRNOP00000026159 | ENSRNOP00000051780 | Cholecystokinin; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion; Belongs to the gastrin/cholecystokinin family | Neuropeptide S; May play an important anorexigenic role. Modulates arousal and anxiety as well as increases locomotor activity. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations | 0.987 |
| Cck | Nts | ENSRNOP00000026159 | ENSRNOP00000005706 | Cholecystokinin; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion; Belongs to the gastrin/cholecystokinin family | Neurotensin/neuromedin N; Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle | 0.988 |
| Cck | Oxt | ENSRNOP00000026159 | ENSRNOP00000028829 | Cholecystokinin; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion; Belongs to the gastrin/cholecystokinin family | Oxytocin-neurophysin 1; Neurophysin 1 specifically binds oxytocin | 0.965 |
| Cck | Oxtr | ENSRNOP00000026159 | ENSRNOP00000007724 | Cholecystokinin; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion; Belongs to the gastrin/cholecystokinin family | Oxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol- calcium second messenger system | 0.963 |
| Cck | Ptgfr | ENSRNOP00000026159 | ENSRNOP00000065253 | Cholecystokinin; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion; Belongs to the gastrin/cholecystokinin family | Prostaglandin F2-alpha receptor; Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum | 0.905 |
| Cck | Trh | ENSRNOP00000026159 | ENSRNOP00000015944 | Cholecystokinin; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion; Belongs to the gastrin/cholecystokinin family | Pro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems | 0.969 |
