node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Gpr135 | Rln3 | ENSRNOP00000005933 | ENSRNOP00000007775 | G-protein coupled receptor 135; Orphan receptor. Has spontaneous activity for beta-arrestin recruitment. Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (By similarity). | Relaxin-3 A chain; May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 and relaxin-3 receptor-2 (By similarity); Belongs to the insulin family. | 0.724 |
Gpr135 | Rxfp3 | ENSRNOP00000005933 | ENSRNOP00000032501 | G-protein coupled receptor 135; Orphan receptor. Has spontaneous activity for beta-arrestin recruitment. Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (By similarity). | Relaxin-3/INSL7 receptor 1 long form. | 0.527 |
Insl3 | Insl6 | ENSRNOP00000025349 | ENSRNOP00000021298 | Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity). | Insulin-like peptide INSL6 A chain; May have a role in sperm development and fertilization. | 0.726 |
Insl3 | Rln1 | ENSRNOP00000025349 | ENSRNOP00000072430 | Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity). | Relaxin A chain; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. | 0.979 |
Insl3 | Rln3 | ENSRNOP00000025349 | ENSRNOP00000007775 | Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity). | Relaxin-3 A chain; May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 and relaxin-3 receptor-2 (By similarity); Belongs to the insulin family. | 0.977 |
Insl3 | Rxfp1 | ENSRNOP00000025349 | ENSRNOP00000033541 | Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity). | Relaxin receptor 1; Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP (By similarity); Belongs to the G-protein coupled receptor 1 family. | 0.992 |
Insl3 | Rxfp2 | ENSRNOP00000025349 | ENSRNOP00000001197 | Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity). | Leucine-rich repeat-containing G protein-coupled receptor 8. | 0.999 |
Insl3 | Rxfp3 | ENSRNOP00000025349 | ENSRNOP00000032501 | Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity). | Relaxin-3/INSL7 receptor 1 long form. | 0.978 |
Insl6 | Insl3 | ENSRNOP00000021298 | ENSRNOP00000025349 | Insulin-like peptide INSL6 A chain; May have a role in sperm development and fertilization. | Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity). | 0.726 |
Insl6 | Rln1 | ENSRNOP00000021298 | ENSRNOP00000072430 | Insulin-like peptide INSL6 A chain; May have a role in sperm development and fertilization. | Relaxin A chain; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. | 0.788 |
Insl6 | Rln3 | ENSRNOP00000021298 | ENSRNOP00000007775 | Insulin-like peptide INSL6 A chain; May have a role in sperm development and fertilization. | Relaxin-3 A chain; May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 and relaxin-3 receptor-2 (By similarity); Belongs to the insulin family. | 0.796 |
Insl6 | Rxfp1 | ENSRNOP00000021298 | ENSRNOP00000033541 | Insulin-like peptide INSL6 A chain; May have a role in sperm development and fertilization. | Relaxin receptor 1; Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP (By similarity); Belongs to the G-protein coupled receptor 1 family. | 0.666 |
Insl6 | Rxfp2 | ENSRNOP00000021298 | ENSRNOP00000001197 | Insulin-like peptide INSL6 A chain; May have a role in sperm development and fertilization. | Leucine-rich repeat-containing G protein-coupled receptor 8. | 0.614 |
Insl6 | Rxfp3 | ENSRNOP00000021298 | ENSRNOP00000032501 | Insulin-like peptide INSL6 A chain; May have a role in sperm development and fertilization. | Relaxin-3/INSL7 receptor 1 long form. | 0.696 |
Nps | Rln3 | ENSRNOP00000051780 | ENSRNOP00000007775 | Neuropeptide S; May play an important anorexigenic role. Modulates arousal and anxiety as well as increases locomotor activity. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations. | Relaxin-3 A chain; May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 and relaxin-3 receptor-2 (By similarity); Belongs to the insulin family. | 0.731 |
Nps | Rxfp3 | ENSRNOP00000051780 | ENSRNOP00000032501 | Neuropeptide S; May play an important anorexigenic role. Modulates arousal and anxiety as well as increases locomotor activity. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations. | Relaxin-3/INSL7 receptor 1 long form. | 0.454 |
Npy5r | Rln3 | ENSRNOP00000018976 | ENSRNOP00000007775 | Neuropeptide Y receptor type 5; Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders. | Relaxin-3 A chain; May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 and relaxin-3 receptor-2 (By similarity); Belongs to the insulin family. | 0.703 |
Npy5r | Rxfp1 | ENSRNOP00000018976 | ENSRNOP00000033541 | Neuropeptide Y receptor type 5; Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders. | Relaxin receptor 1; Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP (By similarity); Belongs to the G-protein coupled receptor 1 family. | 0.472 |
Rlf | Rln1 | ENSRNOP00000039640 | ENSRNOP00000072430 | Rearranged L-myc fusion. | Relaxin A chain; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. | 0.738 |
Rlf | Rln3 | ENSRNOP00000039640 | ENSRNOP00000007775 | Rearranged L-myc fusion. | Relaxin-3 A chain; May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 and relaxin-3 receptor-2 (By similarity); Belongs to the insulin family. | 0.720 |