| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Dhps | Sh3bp5 | ENSRNOP00000005656 | ENSRNOP00000071111 | Deoxyhypusine synthase; Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function. | SH3 domain-binding protein 5; Functions as guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25. Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death; Belongs to the SH3BP5 family. | 0.575 |
| Dhps | Sostdc1 | ENSRNOP00000005656 | ENSRNOP00000008106 | Deoxyhypusine synthase; Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function. | Sclerostin domain-containing protein 1; Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner (By similarity). May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction. Enhances Wnt signaling and inhibits TGF-beta signaling; Belongs to the sclerostin family. | 0.440 |
| Kl | Sostdc1 | ENSRNOP00000001449 | ENSRNOP00000008106 | Klotho peptide; May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 241 and 874, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity). | Sclerostin domain-containing protein 1; Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner (By similarity). May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction. Enhances Wnt signaling and inhibits TGF-beta signaling; Belongs to the sclerostin family. | 0.405 |
| Lrp4 | Sostdc1 | ENSRNOP00000021353 | ENSRNOP00000008106 | Low-density lipoprotein receptor-related protein 4; Mediates SOST-dependent inhibition of bone formation (By similarity). Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling (By similarity). Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN- induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating d [...] | Sclerostin domain-containing protein 1; Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner (By similarity). May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction. Enhances Wnt signaling and inhibits TGF-beta signaling; Belongs to the sclerostin family. | 0.516 |
| Nbl1 | Sostdc1 | ENSRNOP00000064345 | ENSRNOP00000008106 | Neuroblastoma suppressor of tumorigenicity 1; Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process; Belongs to the DAN family. | Sclerostin domain-containing protein 1; Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner (By similarity). May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction. Enhances Wnt signaling and inhibits TGF-beta signaling; Belongs to the sclerostin family. | 0.593 |
| Prr32 | Sostdc1 | ENSRNOP00000065055 | ENSRNOP00000008106 | Proline-rich 32. | Sclerostin domain-containing protein 1; Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner (By similarity). May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction. Enhances Wnt signaling and inhibits TGF-beta signaling; Belongs to the sclerostin family. | 0.433 |
| RGD1560108 | Sostdc1 | ENSRNOP00000046062 | ENSRNOP00000008106 | Similar to RIKEN cDNA 2700081O15 (Predicted). | Sclerostin domain-containing protein 1; Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner (By similarity). May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction. Enhances Wnt signaling and inhibits TGF-beta signaling; Belongs to the sclerostin family. | 0.407 |
| RGD1560108 | Tmem72 | ENSRNOP00000046062 | ENSRNOP00000035275 | Similar to RIKEN cDNA 2700081O15 (Predicted). | Transmembrane protein 72. | 0.551 |
| Sbsn | Sostdc1 | ENSRNOP00000028526 | ENSRNOP00000008106 | Suprabasin. | Sclerostin domain-containing protein 1; Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner (By similarity). May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction. Enhances Wnt signaling and inhibits TGF-beta signaling; Belongs to the sclerostin family. | 0.408 |
| Sfrp2 | Sostdc1 | ENSRNOP00000012659 | ENSRNOP00000008106 | Secreted frizzled-related protein 2. | Sclerostin domain-containing protein 1; Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner (By similarity). May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction. Enhances Wnt signaling and inhibits TGF-beta signaling; Belongs to the sclerostin family. | 0.410 |
| Sh3bp5 | Dhps | ENSRNOP00000071111 | ENSRNOP00000005656 | SH3 domain-binding protein 5; Functions as guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25. Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death; Belongs to the SH3BP5 family. | Deoxyhypusine synthase; Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function. | 0.575 |
| Sh3bp5 | Sostdc1 | ENSRNOP00000071111 | ENSRNOP00000008106 | SH3 domain-binding protein 5; Functions as guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25. Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death; Belongs to the SH3BP5 family. | Sclerostin domain-containing protein 1; Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner (By similarity). May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction. Enhances Wnt signaling and inhibits TGF-beta signaling; Belongs to the sclerostin family. | 0.445 |
| Sostdc1 | Dhps | ENSRNOP00000008106 | ENSRNOP00000005656 | Sclerostin domain-containing protein 1; Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner (By similarity). May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction. Enhances Wnt signaling and inhibits TGF-beta signaling; Belongs to the sclerostin family. | Deoxyhypusine synthase; Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function. | 0.440 |
| Sostdc1 | Kl | ENSRNOP00000008106 | ENSRNOP00000001449 | Sclerostin domain-containing protein 1; Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner (By similarity). May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction. Enhances Wnt signaling and inhibits TGF-beta signaling; Belongs to the sclerostin family. | Klotho peptide; May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 241 and 874, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity). | 0.405 |
| Sostdc1 | Lrp4 | ENSRNOP00000008106 | ENSRNOP00000021353 | Sclerostin domain-containing protein 1; Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner (By similarity). May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction. Enhances Wnt signaling and inhibits TGF-beta signaling; Belongs to the sclerostin family. | Low-density lipoprotein receptor-related protein 4; Mediates SOST-dependent inhibition of bone formation (By similarity). Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling (By similarity). Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN- induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating d [...] | 0.516 |
| Sostdc1 | Nbl1 | ENSRNOP00000008106 | ENSRNOP00000064345 | Sclerostin domain-containing protein 1; Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner (By similarity). May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction. Enhances Wnt signaling and inhibits TGF-beta signaling; Belongs to the sclerostin family. | Neuroblastoma suppressor of tumorigenicity 1; Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process; Belongs to the DAN family. | 0.593 |
| Sostdc1 | Prr32 | ENSRNOP00000008106 | ENSRNOP00000065055 | Sclerostin domain-containing protein 1; Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner (By similarity). May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction. Enhances Wnt signaling and inhibits TGF-beta signaling; Belongs to the sclerostin family. | Proline-rich 32. | 0.433 |
| Sostdc1 | RGD1560108 | ENSRNOP00000008106 | ENSRNOP00000046062 | Sclerostin domain-containing protein 1; Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner (By similarity). May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction. Enhances Wnt signaling and inhibits TGF-beta signaling; Belongs to the sclerostin family. | Similar to RIKEN cDNA 2700081O15 (Predicted). | 0.407 |
| Sostdc1 | Sbsn | ENSRNOP00000008106 | ENSRNOP00000028526 | Sclerostin domain-containing protein 1; Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner (By similarity). May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction. Enhances Wnt signaling and inhibits TGF-beta signaling; Belongs to the sclerostin family. | Suprabasin. | 0.408 |
| Sostdc1 | Sfrp2 | ENSRNOP00000008106 | ENSRNOP00000012659 | Sclerostin domain-containing protein 1; Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner (By similarity). May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction. Enhances Wnt signaling and inhibits TGF-beta signaling; Belongs to the sclerostin family. | Secreted frizzled-related protein 2. | 0.410 |
