Traf2 protein (Rattus norvegicus) - STRING interaction network

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Your Current Organism:

Rattus norvegicus

NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Birc2	Chuk	ENSRNOP00000014560	ENSRNOP00000034134	Baculoviral IAP repeat-containing 2.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.956
Birc2	Ikbkb	ENSRNOP00000014560	ENSRNOP00000025851	Baculoviral IAP repeat-containing 2.	Inhibitor of nuclear factor kappa-B kinase subunit beta; Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is transloca [...]	0.963
Birc2	Ripk1	ENSRNOP00000014560	ENSRNOP00000023962	Baculoviral IAP repeat-containing 2.	Receptor (TNFRSF)-interacting serine-threonine kinase 1 (Predicted).	0.987
Birc2	Tnfrsf1a	ENSRNOP00000014560	ENSRNOP00000042371	Baculoviral IAP repeat-containing 2.	Tumor necrosis factor receptor superfamily member 1A; Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (By similarity).	0.980
Birc2	Tradd	ENSRNOP00000014560	ENSRNOP00000020405	Baculoviral IAP repeat-containing 2.	TNFRSF1A-associated via death domain.	0.988
Birc2	Traf1	ENSRNOP00000014560	ENSRNOP00000076070	Baculoviral IAP repeat-containing 2.	TNF receptor-associated factor.	0.966
Birc2	Traf2	ENSRNOP00000014560	ENSRNOP00000008253	Baculoviral IAP repeat-containing 2.	TNF receptor-associated factor.	0.998
Birc2	Traf5	ENSRNOP00000014560	ENSRNOP00000065556	Baculoviral IAP repeat-containing 2.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.992
Birc2	Traf6	ENSRNOP00000014560	ENSRNOP00000006148	Baculoviral IAP repeat-containing 2.	TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...]	0.978
Chuk	Birc2	ENSRNOP00000034134	ENSRNOP00000014560	Component of inhibitor of nuclear factor kappa B kinase complex.	Baculoviral IAP repeat-containing 2.	0.956
Chuk	Ikbkb	ENSRNOP00000034134	ENSRNOP00000025851	Component of inhibitor of nuclear factor kappa B kinase complex.	Inhibitor of nuclear factor kappa-B kinase subunit beta; Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is transloca [...]	0.999
Chuk	Ripk1	ENSRNOP00000034134	ENSRNOP00000023962	Component of inhibitor of nuclear factor kappa B kinase complex.	Receptor (TNFRSF)-interacting serine-threonine kinase 1 (Predicted).	0.995
Chuk	Tnfrsf1a	ENSRNOP00000034134	ENSRNOP00000042371	Component of inhibitor of nuclear factor kappa B kinase complex.	Tumor necrosis factor receptor superfamily member 1A; Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (By similarity).	0.993
Chuk	Tradd	ENSRNOP00000034134	ENSRNOP00000020405	Component of inhibitor of nuclear factor kappa B kinase complex.	TNFRSF1A-associated via death domain.	0.968
Chuk	Traf1	ENSRNOP00000034134	ENSRNOP00000076070	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor.	0.962
Chuk	Traf2	ENSRNOP00000034134	ENSRNOP00000008253	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor.	0.999
Chuk	Traf5	ENSRNOP00000034134	ENSRNOP00000065556	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.993
Chuk	Traf6	ENSRNOP00000034134	ENSRNOP00000006148	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...]	0.999
Ern1	Traf1	ENSRNOP00000072244	ENSRNOP00000076070	Similar to protein kinase/endoribonuclease(IRE1) alpha (Predicted), isoform CRA_a.	TNF receptor-associated factor.	0.942
Ern1	Traf2	ENSRNOP00000072244	ENSRNOP00000008253	Similar to protein kinase/endoribonuclease(IRE1) alpha (Predicted), isoform CRA_a.	TNF receptor-associated factor.	0.998

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