Mthfd1 protein (Rattus norvegicus) - STRING interaction network

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Mthfd1

C-1-tetrahydrofolate synthase, cytoplasmic; In the C-terminal section; belongs to the formate-- tetrahydrofolate ligase family. (935 aa)

Predicted Functional Partners:

Gart

0.996

Shmt1

0.984

Shmt2

0.977

Atic

0.975

Mthfr

0.965

Dhfr

0.955

Mtr

0.953

Tyms

0.947

Mthfd2

0.942

Gldc

0.939

Your Current Organism:

Rattus norvegicus

NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Atic	Dhfr	ENSRNOP00000021105	ENSRNOP00000018259	Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family.	Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA (By similarity).	0.968
Atic	Gart	ENSRNOP00000021105	ENSRNOP00000033253	Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.999
Atic	Gldc	ENSRNOP00000021105	ENSRNOP00000069291	Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family.	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	0.654
Atic	Mthfd1	ENSRNOP00000021105	ENSRNOP00000008374	Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family.	C-1-tetrahydrofolate synthase, cytoplasmic; In the C-terminal section; belongs to the formate-- tetrahydrofolate ligase family.	0.975
Atic	Mthfd2	ENSRNOP00000021105	ENSRNOP00000014603	Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family.	RCG56426.	0.971
Atic	Mthfr	ENSRNOP00000021105	ENSRNOP00000011384	Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family.	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.804
Atic	Mtr	ENSRNOP00000021105	ENSRNOP00000023973	Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity).	0.924
Atic	Shmt1	ENSRNOP00000021105	ENSRNOP00000007092	Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.989
Atic	Shmt2	ENSRNOP00000021105	ENSRNOP00000011082	Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.987
Atic	Tyms	ENSRNOP00000021105	ENSRNOP00000053086	Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family.	Thymidylate synthase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.	0.912
Dhfr	Atic	ENSRNOP00000018259	ENSRNOP00000021105	Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA (By similarity).	Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family.	0.968
Dhfr	Gart	ENSRNOP00000018259	ENSRNOP00000033253	Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA (By similarity).	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.968
Dhfr	Gldc	ENSRNOP00000018259	ENSRNOP00000069291	Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA (By similarity).	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	0.846
Dhfr	Mthfd1	ENSRNOP00000018259	ENSRNOP00000008374	Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA (By similarity).	C-1-tetrahydrofolate synthase, cytoplasmic; In the C-terminal section; belongs to the formate-- tetrahydrofolate ligase family.	0.955
Dhfr	Mthfd2	ENSRNOP00000018259	ENSRNOP00000014603	Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA (By similarity).	RCG56426.	0.805
Dhfr	Mthfr	ENSRNOP00000018259	ENSRNOP00000011384	Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA (By similarity).	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.936
Dhfr	Mtr	ENSRNOP00000018259	ENSRNOP00000023973	Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA (By similarity).	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity).	0.971
Dhfr	Shmt1	ENSRNOP00000018259	ENSRNOP00000007092	Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA (By similarity).	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.982
Dhfr	Shmt2	ENSRNOP00000018259	ENSRNOP00000011082	Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA (By similarity).	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.974
Dhfr	Tyms	ENSRNOP00000018259	ENSRNOP00000053086	Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA (By similarity).	Thymidylate synthase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.	0.999

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