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Sdc1 protein (Rattus norvegicus) - STRING interaction network
"Sdc1" - Syndecan-1 in Rattus norvegicus
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
Sdc1Syndecan-1; Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (313 aa)    
Predicted Functional Partners:
Gpc1
Glypican-1; Cell surface proteoglycan that bears heparan sulfate. May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling. Binds Cu(2+) or Zn(2+) ions (By similarity). Binds, via the heparan sulfate side chains, alpha-4 (V) collagen [...] (558 aa)
     
 
  0.969
Fgf2
Fibroblast growth factor 2; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Can induce angiogenesis (154 aa)
       
  0.967
Dcn
Decorin; May affect the rate of fibrils formation (By similarity). May be implicated in the dilatation of the rat cervix (354 aa)
     
 
  0.961
Agrn
Agrin; Isoform 1- heparan sulfate basal lamina glycoprotein that plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ) and directs key events in postsynaptic differentiation. This neuron-specific (z+) isoform is a component of the AGRN-LRP4 receptor complex that induces the phosphorylation and activation of MUSK. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Calcium ions are required for maxima [...] (1959 aa)
     
 
  0.950
LOC691984
Similar to Gpc6 protein (Predicted); Cell surface proteoglycan that bears heparan sulfate (555 aa)
     
 
  0.949
Gpc2
Glypican-2; Cell surface proteoglycan that bears heparan sulfate. May fulfill a function related to the motile behaviors of developing neurons (579 aa)
     
 
  0.949
Gpc4
Glypican 4; Cell surface proteoglycan that bears heparan sulfate (557 aa)
     
 
  0.949
Bgn
Biglycan; May be involved in collagen fiber assembly (369 aa)
     
 
  0.948
Vcan
Versican core protein; May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid (3058 aa)
         
  0.946
Hpse2
Heparanase 2 (398 aa)
     
 
  0.944
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Gunn rats, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus norvegicus, Rattus rattiscus, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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