| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Defa24 | Defa5 | ENSRNOP00000018529 | ENSRNOP00000018501 | Defensin 5; Probably contributes to the antimicrobial barrier function of the small intestine; Belongs to the alpha-defensin family. | Neutrophil antibiotic peptide NP-2; Active in vitro against S.aureus, fungi, Gram-positive and Gram-negative bacteria and to a lesser extent against an enveloped virus. | 0.643 |
| Defa24 | Itln1 | ENSRNOP00000018529 | ENSRNOP00000006196 | Defensin 5; Probably contributes to the antimicrobial barrier function of the small intestine; Belongs to the alpha-defensin family. | Intelectin 1. | 0.507 |
| Defa24 | Reg3g | ENSRNOP00000018529 | ENSRNOP00000008665 | Defensin 5; Probably contributes to the antimicrobial barrier function of the small intestine; Belongs to the alpha-defensin family. | Regenerating islet-derived protein 3-gamma 16.5 kDa form; Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. The uncleaved form has bacteriostatic activity, whereas the cleaved form has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. Regulates keratinocyte proliferation and [...] | 0.589 |
| Defa5 | Defa24 | ENSRNOP00000018501 | ENSRNOP00000018529 | Neutrophil antibiotic peptide NP-2; Active in vitro against S.aureus, fungi, Gram-positive and Gram-negative bacteria and to a lesser extent against an enveloped virus. | Defensin 5; Probably contributes to the antimicrobial barrier function of the small intestine; Belongs to the alpha-defensin family. | 0.643 |
| Defa5 | Lyz2 | ENSRNOP00000018501 | ENSRNOP00000007747 | Neutrophil antibiotic peptide NP-2; Active in vitro against S.aureus, fungi, Gram-positive and Gram-negative bacteria and to a lesser extent against an enveloped virus. | Lysozyme C-1; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. In the intestine they may also have a digestive function. | 0.597 |
| Defa5 | Reg3g | ENSRNOP00000018501 | ENSRNOP00000008665 | Neutrophil antibiotic peptide NP-2; Active in vitro against S.aureus, fungi, Gram-positive and Gram-negative bacteria and to a lesser extent against an enveloped virus. | Regenerating islet-derived protein 3-gamma 16.5 kDa form; Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. The uncleaved form has bacteriostatic activity, whereas the cleaved form has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. Regulates keratinocyte proliferation and [...] | 0.648 |
| Il17a | Il22 | ENSRNOP00000016664 | ENSRNOP00000009776 | Interleukin-17A; Ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines. | Similar to TIF alpha protein (Predicted). | 0.923 |
| Il17a | Myd88 | ENSRNOP00000016664 | ENSRNOP00000018341 | Interleukin-17A; Ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] | 0.731 |
| Il17a | Reg3b | ENSRNOP00000016664 | ENSRNOP00000008212 | Interleukin-17A; Ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines. | Regenerating islet-derived protein 3-beta 16.5 kDa form; Bactericidal C-type lectin which acts against several intestinal Gram-positive bacteria and Gram-negative bacteria. Lacks antibacterial activity against S.typhimurium. May play a role in protection against infection with S.enteritidis by inhibiting its translocation from the gut lumen into intestinal tissues and further extraintestinal tissues (By similarity). | 0.506 |
| Il17a | Reg3g | ENSRNOP00000016664 | ENSRNOP00000008665 | Interleukin-17A; Ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines. | Regenerating islet-derived protein 3-gamma 16.5 kDa form; Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. The uncleaved form has bacteriostatic activity, whereas the cleaved form has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. Regulates keratinocyte proliferation and [...] | 0.592 |
| Il22 | Il17a | ENSRNOP00000009776 | ENSRNOP00000016664 | Similar to TIF alpha protein (Predicted). | Interleukin-17A; Ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines. | 0.923 |
| Il22 | Myd88 | ENSRNOP00000009776 | ENSRNOP00000018341 | Similar to TIF alpha protein (Predicted). | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] | 0.602 |
| Il22 | Reg3b | ENSRNOP00000009776 | ENSRNOP00000008212 | Similar to TIF alpha protein (Predicted). | Regenerating islet-derived protein 3-beta 16.5 kDa form; Bactericidal C-type lectin which acts against several intestinal Gram-positive bacteria and Gram-negative bacteria. Lacks antibacterial activity against S.typhimurium. May play a role in protection against infection with S.enteritidis by inhibiting its translocation from the gut lumen into intestinal tissues and further extraintestinal tissues (By similarity). | 0.679 |
| Il22 | Reg3g | ENSRNOP00000009776 | ENSRNOP00000008665 | Similar to TIF alpha protein (Predicted). | Regenerating islet-derived protein 3-gamma 16.5 kDa form; Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. The uncleaved form has bacteriostatic activity, whereas the cleaved form has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. Regulates keratinocyte proliferation and [...] | 0.752 |
| Itln1 | Defa24 | ENSRNOP00000006196 | ENSRNOP00000018529 | Intelectin 1. | Defensin 5; Probably contributes to the antimicrobial barrier function of the small intestine; Belongs to the alpha-defensin family. | 0.507 |
| Itln1 | Lyz2 | ENSRNOP00000006196 | ENSRNOP00000007747 | Intelectin 1. | Lysozyme C-1; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. In the intestine they may also have a digestive function. | 0.587 |
| Itln1 | Reg3b | ENSRNOP00000006196 | ENSRNOP00000008212 | Intelectin 1. | Regenerating islet-derived protein 3-beta 16.5 kDa form; Bactericidal C-type lectin which acts against several intestinal Gram-positive bacteria and Gram-negative bacteria. Lacks antibacterial activity against S.typhimurium. May play a role in protection against infection with S.enteritidis by inhibiting its translocation from the gut lumen into intestinal tissues and further extraintestinal tissues (By similarity). | 0.583 |
| Itln1 | Reg3g | ENSRNOP00000006196 | ENSRNOP00000008665 | Intelectin 1. | Regenerating islet-derived protein 3-gamma 16.5 kDa form; Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. The uncleaved form has bacteriostatic activity, whereas the cleaved form has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. Regulates keratinocyte proliferation and [...] | 0.635 |
| Lypd8 | Reg3b | ENSRNOP00000034245 | ENSRNOP00000008212 | LY6/PLAUR domain-containing 8. | Regenerating islet-derived protein 3-beta 16.5 kDa form; Bactericidal C-type lectin which acts against several intestinal Gram-positive bacteria and Gram-negative bacteria. Lacks antibacterial activity against S.typhimurium. May play a role in protection against infection with S.enteritidis by inhibiting its translocation from the gut lumen into intestinal tissues and further extraintestinal tissues (By similarity). | 0.488 |
| Lypd8 | Reg3g | ENSRNOP00000034245 | ENSRNOP00000008665 | LY6/PLAUR domain-containing 8. | Regenerating islet-derived protein 3-gamma 16.5 kDa form; Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. The uncleaved form has bacteriostatic activity, whereas the cleaved form has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. Regulates keratinocyte proliferation and [...] | 0.607 |
