STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Reg3gRegenerating islet-derived protein 3-gamma; Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. The uncleaved form has bacteriostatic activity, whereas the cleaved form has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. Regulates keratinocyte proliferation and differentiati [...] (174 aa)    
Predicted Functional Partners:
Try10
Trypsin 10; Belongs to the peptidase S1 family
   
 0.950
Prss1
Anionic trypsin-1; Protease, serine, 1 (trypsin 1); Belongs to the peptidase S1 family
   
 0.931
Try4
Protease, serine 3; rCG28262-like; Belongs to the peptidase S1 family
   
 0.930
ENSRNOP00000035514
Protease, serine, 2
   
 0.917
LOC683849
Similar to Anionic trypsin II precursor (Pretrypsinogen II); Belongs to the peptidase S1 family
   
 0.917
LOC102554637
Anionic trypsin-2-like; Belongs to the peptidase S1 family
   
 0.917
Reg3b
Regenerating islet-derived protein 3-beta; Bactericidal C-type lectin which acts against several intestinal Gram-positive bacteria and Gram-negative bacteria. Lacks antibacterial activity against S.typhimurium. May play a role in protection against infection with S.enteritidis by inhibiting its translocation from the gut lumen into intestinal tissues and further extraintestinal tissues (By similarity)
   
 
0.669
Muc2
Intestinal mucin-like protein; Mucin 2
      
 0.592
Zc2hc1c
Zinc finger c2hc domain-containing protein 1c; Zinc finger, C2HC-type containing 1C; Belongs to the ZC2HC1 family
      
 0.544
Defa5
Neutrophil antibiotic peptide NP-2; Active in vitro against S.aureus, fungi, Gram-positive and Gram-negative bacteria and to a lesser extent against an enveloped virus
   
  
 0.504
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Gunn rats, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus rattiscus, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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