node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Abcd4 | Cd320 | ENSRNOP00000016040 | ENSRNOP00000009067 | ATP-binding cassette subfamily D member 4. | CD320 antigen; Receptor for transcobalamin saturated with cobalamin (TCbl). Plays an important role in cobalamin uptake. Plasma membrane protein that is expressed on follicular dendritic cells (FDC) and mediates interaction with germinal center B cells. Functions as costimulator to promote B cell responses to antigenic stimuli; promotes B cell differentiation and proliferation. Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors gen [...] | 0.571 |
Abcd4 | Lmbrd1 | ENSRNOP00000016040 | ENSRNOP00000016887 | ATP-binding cassette subfamily D member 4. | Probable lysosomal cobalamin transporter; Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors (By similarity). | 0.960 |
Abcd4 | Mmab | ENSRNOP00000016040 | ENSRNOP00000066021 | ATP-binding cassette subfamily D member 4. | Corrinoid adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. | 0.439 |
Abcd4 | Mmadhc | ENSRNOP00000016040 | ENSRNOP00000058814 | ATP-binding cassette subfamily D member 4. | Methylmalonic aciduria and homocystinuria type D homolog, mitochondrial; Involved in cobalamin metabolism. Plays a role in regulating the biosynthesis of two coenzymes, methylcobalamin and adenosylcobalamin. Plays a role in regulating the proportion of methylcobalamin and adenosylcobalamin. Promotes oxidation of cob(II)alamin bound to MMACHC. | 0.556 |
Abcd4 | Mmut | ENSRNOP00000016040 | ENSRNOP00000064363 | ATP-binding cassette subfamily D member 4. | Methylmalonyl-CoA mutase. | 0.625 |
Abcd4 | Mtr | ENSRNOP00000016040 | ENSRNOP00000023973 | ATP-binding cassette subfamily D member 4. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). | 0.421 |
Abcd4 | Tcn2 | ENSRNOP00000016040 | ENSRNOP00000005934 | ATP-binding cassette subfamily D member 4. | Transcobalamin-2; Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells. | 0.449 |
Cbl | Cblif | ENSRNOP00000063226 | ENSRNOP00000028507 | Cbl proto-oncogene. | Cobalamin binding intrinsic factor; Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis (By similarity). | 0.680 |
Cbl | Cd320 | ENSRNOP00000063226 | ENSRNOP00000009067 | Cbl proto-oncogene. | CD320 antigen; Receptor for transcobalamin saturated with cobalamin (TCbl). Plays an important role in cobalamin uptake. Plasma membrane protein that is expressed on follicular dendritic cells (FDC) and mediates interaction with germinal center B cells. Functions as costimulator to promote B cell responses to antigenic stimuli; promotes B cell differentiation and proliferation. Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors gen [...] | 0.536 |
Cbl | Cubn | ENSRNOP00000063226 | ENSRNOP00000075097 | Cbl proto-oncogene. | Cubilin; Endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake. Acts together with LRP2 to mediate endocytosis of high-density lipoproteins, GC, hemoglobin, ALB, TF and SCGB1A1. Acts together with AMN to mediate endocytosis of the CBLIF-cobalamin complex. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the CBLIF-cobalamin complex. Ligand binding requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal t [...] | 0.512 |
Cbl | Mmab | ENSRNOP00000063226 | ENSRNOP00000066021 | Cbl proto-oncogene. | Corrinoid adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. | 0.439 |
Cbl | Mmadhc | ENSRNOP00000063226 | ENSRNOP00000058814 | Cbl proto-oncogene. | Methylmalonic aciduria and homocystinuria type D homolog, mitochondrial; Involved in cobalamin metabolism. Plays a role in regulating the biosynthesis of two coenzymes, methylcobalamin and adenosylcobalamin. Plays a role in regulating the proportion of methylcobalamin and adenosylcobalamin. Promotes oxidation of cob(II)alamin bound to MMACHC. | 0.732 |
Cbl | Mmut | ENSRNOP00000063226 | ENSRNOP00000064363 | Cbl proto-oncogene. | Methylmalonyl-CoA mutase. | 0.493 |
Cbl | Mtr | ENSRNOP00000063226 | ENSRNOP00000023973 | Cbl proto-oncogene. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). | 0.498 |
Cbl | Tcn2 | ENSRNOP00000063226 | ENSRNOP00000005934 | Cbl proto-oncogene. | Transcobalamin-2; Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells. | 0.849 |
Cblif | Cbl | ENSRNOP00000028507 | ENSRNOP00000063226 | Cobalamin binding intrinsic factor; Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis (By similarity). | Cbl proto-oncogene. | 0.680 |
Cblif | Cd320 | ENSRNOP00000028507 | ENSRNOP00000009067 | Cobalamin binding intrinsic factor; Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis (By similarity). | CD320 antigen; Receptor for transcobalamin saturated with cobalamin (TCbl). Plays an important role in cobalamin uptake. Plasma membrane protein that is expressed on follicular dendritic cells (FDC) and mediates interaction with germinal center B cells. Functions as costimulator to promote B cell responses to antigenic stimuli; promotes B cell differentiation and proliferation. Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors gen [...] | 0.569 |
Cblif | Cubn | ENSRNOP00000028507 | ENSRNOP00000075097 | Cobalamin binding intrinsic factor; Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis (By similarity). | Cubilin; Endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake. Acts together with LRP2 to mediate endocytosis of high-density lipoproteins, GC, hemoglobin, ALB, TF and SCGB1A1. Acts together with AMN to mediate endocytosis of the CBLIF-cobalamin complex. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the CBLIF-cobalamin complex. Ligand binding requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal t [...] | 0.994 |
Cd320 | Abcd4 | ENSRNOP00000009067 | ENSRNOP00000016040 | CD320 antigen; Receptor for transcobalamin saturated with cobalamin (TCbl). Plays an important role in cobalamin uptake. Plasma membrane protein that is expressed on follicular dendritic cells (FDC) and mediates interaction with germinal center B cells. Functions as costimulator to promote B cell responses to antigenic stimuli; promotes B cell differentiation and proliferation. Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors gen [...] | ATP-binding cassette subfamily D member 4. | 0.571 |
Cd320 | Cbl | ENSRNOP00000009067 | ENSRNOP00000063226 | CD320 antigen; Receptor for transcobalamin saturated with cobalamin (TCbl). Plays an important role in cobalamin uptake. Plasma membrane protein that is expressed on follicular dendritic cells (FDC) and mediates interaction with germinal center B cells. Functions as costimulator to promote B cell responses to antigenic stimuli; promotes B cell differentiation and proliferation. Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors gen [...] | Cbl proto-oncogene. | 0.536 |