| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Depdc5 | Flcn | ENSRNOP00000073874 | ENSRNOP00000004412 | DEP domain-containing 5, GATOR1 subcomplex subunit. | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity). Belongs to the folliculin family. | 0.504 |
| Depdc5 | Lamtor1 | ENSRNOP00000073874 | ENSRNOP00000027150 | DEP domain-containing 5, GATOR1 subcomplex subunit. | Ragulator complex protein LAMTOR1; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulat [...] | 0.836 |
| Depdc5 | Mtor | ENSRNOP00000073874 | ENSRNOP00000014167 | DEP domain-containing 5, GATOR1 subcomplex subunit. | Serine/threonine-protein kinase mTOR; Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (By similarity). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins (By similarity). Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (By similarity). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome [...] | 0.758 |
| Depdc5 | Nprl2 | ENSRNOP00000073874 | ENSRNOP00000046410 | DEP domain-containing 5, GATOR1 subcomplex subunit. | Tumor suppressor candidate 4, isoform CRA_a. | 0.999 |
| Depdc5 | Nprl3 | ENSRNOP00000073874 | ENSRNOP00000071482 | DEP domain-containing 5, GATOR1 subcomplex subunit. | NPR3-like, GATOR1 complex subunit. | 0.999 |
| Depdc5 | Rptor | ENSRNOP00000073874 | ENSRNOP00000005337 | DEP domain-containing 5, GATOR1 subcomplex subunit. | Regulatory-associated protein of MTOR, complex 1. | 0.627 |
| Depdc5 | Rraga | ENSRNOP00000073874 | ENSRNOP00000009225 | DEP domain-containing 5, GATOR1 subcomplex subunit. | Ras-related GTP-binding protein A; Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. Bel [...] | 0.990 |
| Depdc5 | Rragc | ENSRNOP00000073874 | ENSRNOP00000023514 | DEP domain-containing 5, GATOR1 subcomplex subunit. | Ras-related GTP-binding C. | 0.989 |
| Depdc5 | Rragd | ENSRNOP00000073874 | ENSRNOP00000061453 | DEP domain-containing 5, GATOR1 subcomplex subunit. | Ras-related GTP binding D (Predicted), isoform CRA_b. | 0.926 |
| Flcn | Depdc5 | ENSRNOP00000004412 | ENSRNOP00000073874 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity). Belongs to the folliculin family. | DEP domain-containing 5, GATOR1 subcomplex subunit. | 0.504 |
| Flcn | Fnip2 | ENSRNOP00000004412 | ENSRNOP00000031096 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity). Belongs to the folliculin family. | Folliculin-interacting protein 2. | 0.999 |
| Flcn | Lamtor1 | ENSRNOP00000004412 | ENSRNOP00000027150 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity). Belongs to the folliculin family. | Ragulator complex protein LAMTOR1; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulat [...] | 0.853 |
| Flcn | Mtor | ENSRNOP00000004412 | ENSRNOP00000014167 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity). Belongs to the folliculin family. | Serine/threonine-protein kinase mTOR; Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (By similarity). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins (By similarity). Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (By similarity). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome [...] | 0.621 |
| Flcn | Nprl2 | ENSRNOP00000004412 | ENSRNOP00000046410 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity). Belongs to the folliculin family. | Tumor suppressor candidate 4, isoform CRA_a. | 0.752 |
| Flcn | Nprl3 | ENSRNOP00000004412 | ENSRNOP00000071482 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity). Belongs to the folliculin family. | NPR3-like, GATOR1 complex subunit. | 0.719 |
| Flcn | Rptor | ENSRNOP00000004412 | ENSRNOP00000005337 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity). Belongs to the folliculin family. | Regulatory-associated protein of MTOR, complex 1. | 0.410 |
| Flcn | Rraga | ENSRNOP00000004412 | ENSRNOP00000009225 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity). Belongs to the folliculin family. | Ras-related GTP-binding protein A; Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. Bel [...] | 0.987 |
| Flcn | Rragc | ENSRNOP00000004412 | ENSRNOP00000023514 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity). Belongs to the folliculin family. | Ras-related GTP-binding C. | 0.994 |
| Flcn | Rragd | ENSRNOP00000004412 | ENSRNOP00000061453 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity). Belongs to the folliculin family. | Ras-related GTP binding D (Predicted), isoform CRA_b. | 0.987 |
| Fnip2 | Flcn | ENSRNOP00000031096 | ENSRNOP00000004412 | Folliculin-interacting protein 2. | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity). Belongs to the folliculin family. | 0.999 |
STRING v12.5 is now available!
