node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Atad2 | Casp8ap2 | ENSRNOP00000008508 | ENSRNOP00000009227 | ATPase family, AAA domain-containing 2. | Caspase 8-associated protein 2. | 0.565 |
Atad2 | Dscc1 | ENSRNOP00000008508 | ENSRNOP00000038101 | ATPase family, AAA domain-containing 2. | DNA replication and sister chromatid cohesion 1. | 0.643 |
Atad2 | Gas2l3 | ENSRNOP00000008508 | ENSRNOP00000033340 | ATPase family, AAA domain-containing 2. | Growth arrest-specific 2-like 3. | 0.644 |
Atad2 | Ubr7 | ENSRNOP00000008508 | ENSRNOP00000075090 | ATPase family, AAA domain-containing 2. | Ubiquitin protein ligase E3 component n-recognin 7. | 0.610 |
Atad2 | Wdr76 | ENSRNOP00000008508 | ENSRNOP00000034184 | ATPase family, AAA domain-containing 2. | WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Belongs to the WD repeat DDB2/WDR76 family. | 0.740 |
Casp8 | Casp8ap2 | ENSRNOP00000016613 | ENSRNOP00000009227 | Caspase-8 subunit p10; Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CA [...] | Caspase 8-associated protein 2. | 0.849 |
Casp8ap2 | Atad2 | ENSRNOP00000009227 | ENSRNOP00000008508 | Caspase 8-associated protein 2. | ATPase family, AAA domain-containing 2. | 0.565 |
Casp8ap2 | Casp8 | ENSRNOP00000009227 | ENSRNOP00000016613 | Caspase 8-associated protein 2. | Caspase-8 subunit p10; Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CA [...] | 0.849 |
Casp8ap2 | Dscc1 | ENSRNOP00000009227 | ENSRNOP00000038101 | Caspase 8-associated protein 2. | DNA replication and sister chromatid cohesion 1. | 0.570 |
Casp8ap2 | Gas2l3 | ENSRNOP00000009227 | ENSRNOP00000033340 | Caspase 8-associated protein 2. | Growth arrest-specific 2-like 3. | 0.566 |
Casp8ap2 | Lsm11 | ENSRNOP00000009227 | ENSRNOP00000007267 | Caspase 8-associated protein 2. | Similar to U7 snRNA-associated Sm-like protein Lsm11 (Predicted). | 0.583 |
Casp8ap2 | Npat | ENSRNOP00000009227 | ENSRNOP00000047149 | Caspase 8-associated protein 2. | Nuclear protein, co-activator of histone transcription. | 0.627 |
Casp8ap2 | Pdcd10 | ENSRNOP00000009227 | ENSRNOP00000013585 | Caspase 8-associated protein 2. | Programmed cell death protein 10; Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development. | 0.731 |
Casp8ap2 | Sympk | ENSRNOP00000009227 | ENSRNOP00000019814 | Caspase 8-associated protein 2. | Symplekin. | 0.563 |
Casp8ap2 | Ubr7 | ENSRNOP00000009227 | ENSRNOP00000075090 | Caspase 8-associated protein 2. | Ubiquitin protein ligase E3 component n-recognin 7. | 0.568 |
Casp8ap2 | Wdr76 | ENSRNOP00000009227 | ENSRNOP00000034184 | Caspase 8-associated protein 2. | WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Belongs to the WD repeat DDB2/WDR76 family. | 0.575 |
Dscc1 | Atad2 | ENSRNOP00000038101 | ENSRNOP00000008508 | DNA replication and sister chromatid cohesion 1. | ATPase family, AAA domain-containing 2. | 0.643 |
Dscc1 | Casp8ap2 | ENSRNOP00000038101 | ENSRNOP00000009227 | DNA replication and sister chromatid cohesion 1. | Caspase 8-associated protein 2. | 0.570 |
Dscc1 | Gas2l3 | ENSRNOP00000038101 | ENSRNOP00000033340 | DNA replication and sister chromatid cohesion 1. | Growth arrest-specific 2-like 3. | 0.681 |
Dscc1 | Ubr7 | ENSRNOP00000038101 | ENSRNOP00000075090 | DNA replication and sister chromatid cohesion 1. | Ubiquitin protein ligase E3 component n-recognin 7. | 0.565 |