node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Casp3 | Casp7 | ENSRNOP00000014096 | ENSRNOP00000075193 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. | Caspase 7, isoform CRA_c; Belongs to the peptidase C14A family. | 0.918 |
Casp3 | Casp9 | ENSRNOP00000014096 | ENSRNOP00000017972 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. | Caspase 9, isoform CRA_a; Belongs to the peptidase C14A family. | 0.998 |
Casp3 | Diablo | ENSRNOP00000014096 | ENSRNOP00000046476 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. | Diablo homolog (Drosophila), isoform CRA_b. | 0.891 |
Casp3 | Htra2 | ENSRNOP00000014096 | ENSRNOP00000030076 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. | HtrA serine peptidase 2. | 0.615 |
Casp3 | LOC100360940 | ENSRNOP00000014096 | ENSRNOP00000011308 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. | Diablo-like. | 0.474 |
Casp3 | Ripk1 | ENSRNOP00000014096 | ENSRNOP00000023962 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. | Receptor (TNFRSF)-interacting serine-threonine kinase 1 (Predicted). | 0.934 |
Casp3 | Xiap | ENSRNOP00000014096 | ENSRNOP00000071268 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. | E3 ubiquitin-protein ligase XIAP; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligas [...] | 0.999 |
Casp7 | Casp3 | ENSRNOP00000075193 | ENSRNOP00000014096 | Caspase 7, isoform CRA_c; Belongs to the peptidase C14A family. | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. | 0.918 |
Casp7 | Casp9 | ENSRNOP00000075193 | ENSRNOP00000017972 | Caspase 7, isoform CRA_c; Belongs to the peptidase C14A family. | Caspase 9, isoform CRA_a; Belongs to the peptidase C14A family. | 0.948 |
Casp7 | Diablo | ENSRNOP00000075193 | ENSRNOP00000046476 | Caspase 7, isoform CRA_c; Belongs to the peptidase C14A family. | Diablo homolog (Drosophila), isoform CRA_b. | 0.917 |
Casp7 | LOC100360940 | ENSRNOP00000075193 | ENSRNOP00000011308 | Caspase 7, isoform CRA_c; Belongs to the peptidase C14A family. | Diablo-like. | 0.548 |
Casp7 | Ripk1 | ENSRNOP00000075193 | ENSRNOP00000023962 | Caspase 7, isoform CRA_c; Belongs to the peptidase C14A family. | Receptor (TNFRSF)-interacting serine-threonine kinase 1 (Predicted). | 0.673 |
Casp7 | Xiap | ENSRNOP00000075193 | ENSRNOP00000071268 | Caspase 7, isoform CRA_c; Belongs to the peptidase C14A family. | E3 ubiquitin-protein ligase XIAP; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligas [...] | 0.999 |
Casp9 | Casp3 | ENSRNOP00000017972 | ENSRNOP00000014096 | Caspase 9, isoform CRA_a; Belongs to the peptidase C14A family. | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. | 0.998 |
Casp9 | Casp7 | ENSRNOP00000017972 | ENSRNOP00000075193 | Caspase 9, isoform CRA_a; Belongs to the peptidase C14A family. | Caspase 7, isoform CRA_c; Belongs to the peptidase C14A family. | 0.948 |
Casp9 | Diablo | ENSRNOP00000017972 | ENSRNOP00000046476 | Caspase 9, isoform CRA_a; Belongs to the peptidase C14A family. | Diablo homolog (Drosophila), isoform CRA_b. | 0.955 |
Casp9 | Htra2 | ENSRNOP00000017972 | ENSRNOP00000030076 | Caspase 9, isoform CRA_a; Belongs to the peptidase C14A family. | HtrA serine peptidase 2. | 0.674 |
Casp9 | LOC100360940 | ENSRNOP00000017972 | ENSRNOP00000011308 | Caspase 9, isoform CRA_a; Belongs to the peptidase C14A family. | Diablo-like. | 0.715 |
Casp9 | Ripk1 | ENSRNOP00000017972 | ENSRNOP00000023962 | Caspase 9, isoform CRA_a; Belongs to the peptidase C14A family. | Receptor (TNFRSF)-interacting serine-threonine kinase 1 (Predicted). | 0.477 |
Casp9 | Ripk2 | ENSRNOP00000017972 | ENSRNOP00000012963 | Caspase 9, isoform CRA_a; Belongs to the peptidase C14A family. | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. | 0.410 |