node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Actn3 | Atp2a1 | ENSRNOP00000026812 | ENSRNOP00000067246 | Skeletal muscle-specific alpha-actinin 3. | Cation_ATPase_C domain-containing protein. | 0.871 |
Actn3 | Casq1 | ENSRNOP00000026812 | ENSRNOP00000009344 | Skeletal muscle-specific alpha-actinin 3. | Calsequestrin-1; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction (By similarity). Negatively regulates store-operated Ca(2+) entry (SOCE) activity (By similarity). | 0.757 |
Actn3 | Casq2 | ENSRNOP00000026812 | ENSRNOP00000021846 | Skeletal muscle-specific alpha-actinin 3. | Calsequestrin-2; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats (By similarity). | 0.463 |
Actn3 | Myl1 | ENSRNOP00000026812 | ENSRNOP00000017838 | Skeletal muscle-specific alpha-actinin 3. | Myosin light chain 1/3, skeletal muscle isoform; Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function. | 0.922 |
Actn3 | Myoz1 | ENSRNOP00000026812 | ENSRNOP00000070869 | Skeletal muscle-specific alpha-actinin 3. | Myozenin 1. | 0.954 |
Actn3 | Ryr1 | ENSRNOP00000026812 | ENSRNOP00000073446 | Skeletal muscle-specific alpha-actinin 3. | Ryanodine receptor 1; Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm (By similarity). Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. [...] | 0.596 |
Actn3 | Srl | ENSRNOP00000026812 | ENSRNOP00000039064 | Skeletal muscle-specific alpha-actinin 3. | Sarcalumenin; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | 0.583 |
Atp2a1 | Actn3 | ENSRNOP00000067246 | ENSRNOP00000026812 | Cation_ATPase_C domain-containing protein. | Skeletal muscle-specific alpha-actinin 3. | 0.871 |
Atp2a1 | Casq1 | ENSRNOP00000067246 | ENSRNOP00000009344 | Cation_ATPase_C domain-containing protein. | Calsequestrin-1; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction (By similarity). Negatively regulates store-operated Ca(2+) entry (SOCE) activity (By similarity). | 0.870 |
Atp2a1 | Casq2 | ENSRNOP00000067246 | ENSRNOP00000021846 | Cation_ATPase_C domain-containing protein. | Calsequestrin-2; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats (By similarity). | 0.659 |
Atp2a1 | Myl1 | ENSRNOP00000067246 | ENSRNOP00000017838 | Cation_ATPase_C domain-containing protein. | Myosin light chain 1/3, skeletal muscle isoform; Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function. | 0.653 |
Atp2a1 | Myoz1 | ENSRNOP00000067246 | ENSRNOP00000070869 | Cation_ATPase_C domain-containing protein. | Myozenin 1. | 0.672 |
Atp2a1 | Ryr1 | ENSRNOP00000067246 | ENSRNOP00000073446 | Cation_ATPase_C domain-containing protein. | Ryanodine receptor 1; Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm (By similarity). Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. [...] | 0.915 |
Atp2a1 | Ryr2 | ENSRNOP00000067246 | ENSRNOP00000059019 | Cation_ATPase_C domain-containing protein. | Ryanodine receptor 2; Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development (By similarity); Belongs to t [...] | 0.673 |
Atp2a1 | Ryr3 | ENSRNOP00000067246 | ENSRNOP00000040240 | Cation_ATPase_C domain-containing protein. | Ryanodine receptor 3. | 0.620 |
Atp2a1 | Srl | ENSRNOP00000067246 | ENSRNOP00000039064 | Cation_ATPase_C domain-containing protein. | Sarcalumenin; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | 0.851 |
Atp2a1 | Trdn | ENSRNOP00000067246 | ENSRNOP00000041570 | Cation_ATPase_C domain-containing protein. | Triadin; Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact. Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. | 0.770 |
Casq1 | Actn3 | ENSRNOP00000009344 | ENSRNOP00000026812 | Calsequestrin-1; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction (By similarity). Negatively regulates store-operated Ca(2+) entry (SOCE) activity (By similarity). | Skeletal muscle-specific alpha-actinin 3. | 0.757 |
Casq1 | Atp2a1 | ENSRNOP00000009344 | ENSRNOP00000067246 | Calsequestrin-1; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction (By similarity). Negatively regulates store-operated Ca(2+) entry (SOCE) activity (By similarity). | Cation_ATPase_C domain-containing protein. | 0.870 |
Casq1 | Casq2 | ENSRNOP00000009344 | ENSRNOP00000021846 | Calsequestrin-1; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction (By similarity). Negatively regulates store-operated Ca(2+) entry (SOCE) activity (By similarity). | Calsequestrin-2; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats (By similarity). | 0.916 |