Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Afg3l1 | Clpp | ENSRNOP00000037053 | ENSRNOP00000066481 | AFG3(ATPase family gene 3)-like 1 (S. cerevisiae). | ATP-dependent Clp protease proteolytic subunit. | 0.477 |
| Afg3l1 | LOC100911485 | ENSRNOP00000037053 | ENSRNOP00000059463 | AFG3(ATPase family gene 3)-like 1 (S. cerevisiae). | Mitofusin-2; Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion. Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events. Overexpression induces the formation of mitochondrial networks. Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (By similarity). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Plays an important role in the regulation [...] | 0.471 |
| Afg3l1 | Mfn2 | ENSRNOP00000037053 | ENSRNOP00000070746 | AFG3(ATPase family gene 3)-like 1 (S. cerevisiae). | Mitofusin 2. | 0.471 |
| Afg3l1 | Oma1 | ENSRNOP00000037053 | ENSRNOP00000009515 | AFG3(ATPase family gene 3)-like 1 (S. cerevisiae). | Metalloendopeptidase OMA1, mitochondrial; Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. May also cleave UQCC3 under these conditions. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions. Belongs to the peptidase [...] | 0.813 |
| Afg3l1 | Opa1 | ENSRNOP00000037053 | ENSRNOP00000002343 | AFG3(ATPase family gene 3)-like 1 (S. cerevisiae). | Dynamin-like 120 kDa protein, mitochondrial; Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission. Coexpression of isoform 1 with shorter alternative products is required for optimal activity in promoting mitochondrial fusion. Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation. The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes (By similarity). Plays a role in [...] | 0.407 |
| Afg3l1 | Parl | ENSRNOP00000037053 | ENSRNOP00000029124 | AFG3(ATPase family gene 3)-like 1 (S. cerevisiae). | Presenilins-associated rhomboid-like protein, mitochondrial; Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals (By similarity). Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain (By similarity). | 0.656 |
| Afg3l1 | Spg7 | ENSRNOP00000037053 | ENSRNOP00000073276 | AFG3(ATPase family gene 3)-like 1 (S. cerevisiae). | Paraplegin; ATP-dependent zinc metalloprotease. Plays a role in the formation and regulation of the mitochondrial permeability transition pore (mPTP) and its proteolytic activity is dispensable for this function ; In the N-terminal section; belongs to the AAA ATPase family. | 0.766 |
| Atp23 | Oma1 | ENSRNOP00000064274 | ENSRNOP00000009515 | Mitochondrial inner membrane protease ATP23; Belongs to the peptidase M76 family. | Metalloendopeptidase OMA1, mitochondrial; Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. May also cleave UQCC3 under these conditions. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions. Belongs to the peptidase [...] | 0.778 |
| Atp23 | Parl | ENSRNOP00000064274 | ENSRNOP00000029124 | Mitochondrial inner membrane protease ATP23; Belongs to the peptidase M76 family. | Presenilins-associated rhomboid-like protein, mitochondrial; Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals (By similarity). Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain (By similarity). | 0.473 |
| Atp23 | Spg7 | ENSRNOP00000064274 | ENSRNOP00000073276 | Mitochondrial inner membrane protease ATP23; Belongs to the peptidase M76 family. | Paraplegin; ATP-dependent zinc metalloprotease. Plays a role in the formation and regulation of the mitochondrial permeability transition pore (mPTP) and its proteolytic activity is dispensable for this function ; In the N-terminal section; belongs to the AAA ATPase family. | 0.467 |
| Clpp | Afg3l1 | ENSRNOP00000066481 | ENSRNOP00000037053 | ATP-dependent Clp protease proteolytic subunit. | AFG3(ATPase family gene 3)-like 1 (S. cerevisiae). | 0.477 |
| Clpp | LOC100911485 | ENSRNOP00000066481 | ENSRNOP00000059463 | ATP-dependent Clp protease proteolytic subunit. | Mitofusin-2; Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion. Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events. Overexpression induces the formation of mitochondrial networks. Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (By similarity). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Plays an important role in the regulation [...] | 0.523 |
| Clpp | Mfn2 | ENSRNOP00000066481 | ENSRNOP00000070746 | ATP-dependent Clp protease proteolytic subunit. | Mitofusin 2. | 0.523 |
| Clpp | Oma1 | ENSRNOP00000066481 | ENSRNOP00000009515 | ATP-dependent Clp protease proteolytic subunit. | Metalloendopeptidase OMA1, mitochondrial; Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. May also cleave UQCC3 under these conditions. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions. Belongs to the peptidase [...] | 0.783 |
| Clpp | Parl | ENSRNOP00000066481 | ENSRNOP00000029124 | ATP-dependent Clp protease proteolytic subunit. | Presenilins-associated rhomboid-like protein, mitochondrial; Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals (By similarity). Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain (By similarity). | 0.672 |
| Clpp | Spg7 | ENSRNOP00000066481 | ENSRNOP00000073276 | ATP-dependent Clp protease proteolytic subunit. | Paraplegin; ATP-dependent zinc metalloprotease. Plays a role in the formation and regulation of the mitochondrial permeability transition pore (mPTP) and its proteolytic activity is dispensable for this function ; In the N-terminal section; belongs to the AAA ATPase family. | 0.780 |
| Clpp | Yme1l1 | ENSRNOP00000066481 | ENSRNOP00000023395 | ATP-dependent Clp protease proteolytic subunit. | ATP-dependent zinc metalloprotease YME1L1; ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region (By similarity). Plays an important role in regulating mitochondrial morphology and function by cleaving OPA1 at position S2, giving rise to a form of OPA1 that promotes maintenance of normal mitochondrial structure (By similarity). Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mito [...] | 0.829 |
| Clpp | Yme1l1-2 | ENSRNOP00000066481 | ENSRNOP00000071378 | ATP-dependent Clp protease proteolytic subunit. | ATP-dependent zinc metalloprotease YME1L1. | 0.829 |
| LOC100911485 | Afg3l1 | ENSRNOP00000059463 | ENSRNOP00000037053 | Mitofusin-2; Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion. Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events. Overexpression induces the formation of mitochondrial networks. Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (By similarity). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Plays an important role in the regulation [...] | AFG3(ATPase family gene 3)-like 1 (S. cerevisiae). | 0.471 |
| LOC100911485 | Clpp | ENSRNOP00000059463 | ENSRNOP00000066481 | Mitofusin-2; Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion. Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events. Overexpression induces the formation of mitochondrial networks. Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (By similarity). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Plays an important role in the regulation [...] | ATP-dependent Clp protease proteolytic subunit. | 0.523 |
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