node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ak9 | Dtymk | ENSRNOP00000054014 | ENSRNOP00000025644 | Adenylate kinase 9. | Deoxythymidylate kinase (Predicted), isoform CRA_b. | 0.964 |
Ak9 | Dut | ENSRNOP00000054014 | ENSRNOP00000009549 | Adenylate kinase 9. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. Inhibits peroxisome proliferator-activated receptor (PPAR) activity by binding of its N-terminal to PPAR, preventing the latter's dimerization with retinoid X receptor. | 0.947 |
Ak9 | Itpa | ENSRNOP00000054014 | ENSRNOP00000028838 | Adenylate kinase 9. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.931 |
Ak9 | Nme1 | ENSRNOP00000054014 | ENSRNOP00000003658 | Adenylate kinase 9. | Nucleoside diphosphate kinase A; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for n [...] | 0.947 |
Ak9 | Nme2 | ENSRNOP00000054014 | ENSRNOP00000003611 | Adenylate kinase 9. | Nucleoside diphosphate kinase B; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically. Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE I [...] | 0.947 |
Ak9 | Nme6 | ENSRNOP00000054014 | ENSRNOP00000028125 | Adenylate kinase 9. | Nucleoside diphosphate kinase 6; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.971 |
Ak9 | Nme7 | ENSRNOP00000054014 | ENSRNOP00000055684 | Adenylate kinase 9. | Nucleoside diphosphate kinase 7; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.947 |
Ak9 | Tk1 | ENSRNOP00000054014 | ENSRNOP00000067459 | Adenylate kinase 9. | Thymidine kinase, cytosolic; Belongs to the thymidine kinase family. | 0.423 |
Ak9 | Tyms | ENSRNOP00000054014 | ENSRNOP00000053086 | Adenylate kinase 9. | Thymidylate synthase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. | 0.479 |
Dctd | Dtymk | ENSRNOP00000017670 | ENSRNOP00000025644 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. | Deoxythymidylate kinase (Predicted), isoform CRA_b. | 0.966 |
Dctd | Dut | ENSRNOP00000017670 | ENSRNOP00000009549 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. Inhibits peroxisome proliferator-activated receptor (PPAR) activity by binding of its N-terminal to PPAR, preventing the latter's dimerization with retinoid X receptor. | 0.962 |
Dctd | Tk1 | ENSRNOP00000017670 | ENSRNOP00000067459 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. | Thymidine kinase, cytosolic; Belongs to the thymidine kinase family. | 0.980 |
Dctd | Tyms | ENSRNOP00000017670 | ENSRNOP00000053086 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. | Thymidylate synthase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. | 0.984 |
Dtymk | Ak9 | ENSRNOP00000025644 | ENSRNOP00000054014 | Deoxythymidylate kinase (Predicted), isoform CRA_b. | Adenylate kinase 9. | 0.964 |
Dtymk | Dctd | ENSRNOP00000025644 | ENSRNOP00000017670 | Deoxythymidylate kinase (Predicted), isoform CRA_b. | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. | 0.966 |
Dtymk | Dut | ENSRNOP00000025644 | ENSRNOP00000009549 | Deoxythymidylate kinase (Predicted), isoform CRA_b. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. Inhibits peroxisome proliferator-activated receptor (PPAR) activity by binding of its N-terminal to PPAR, preventing the latter's dimerization with retinoid X receptor. | 0.959 |
Dtymk | Itpa | ENSRNOP00000025644 | ENSRNOP00000028838 | Deoxythymidylate kinase (Predicted), isoform CRA_b. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.615 |
Dtymk | Nme1 | ENSRNOP00000025644 | ENSRNOP00000003658 | Deoxythymidylate kinase (Predicted), isoform CRA_b. | Nucleoside diphosphate kinase A; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for n [...] | 0.955 |
Dtymk | Nme2 | ENSRNOP00000025644 | ENSRNOP00000003611 | Deoxythymidylate kinase (Predicted), isoform CRA_b. | Nucleoside diphosphate kinase B; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically. Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE I [...] | 0.954 |
Dtymk | Nme6 | ENSRNOP00000025644 | ENSRNOP00000028125 | Deoxythymidylate kinase (Predicted), isoform CRA_b. | Nucleoside diphosphate kinase 6; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.953 |