node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ccl11 | Ccl26 | ENSRNOP00000009756 | ENSRNOP00000001963 | Eotaxin; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions; Belongs to the intercrine beta (chemokine CC) family. | C-C motif chemokine ligand 26. | 0.993 |
Ccl11 | Ccl27 | ENSRNOP00000009756 | ENSRNOP00000057330 | Eotaxin; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions; Belongs to the intercrine beta (chemokine CC) family. | Chemokine (C-C motif) ligand 27 (Predicted), isoform CRA_b. | 0.985 |
Ccl11 | Ccl5 | ENSRNOP00000009756 | ENSRNOP00000014865 | Eotaxin; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions; Belongs to the intercrine beta (chemokine CC) family. | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | 0.975 |
Ccl11 | Ccr1 | ENSRNOP00000009756 | ENSRNOP00000008772 | Eotaxin; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions; Belongs to the intercrine beta (chemokine CC) family. | Macrophage inflammatory protein-1 alpha receptor; Belongs to the G-protein coupled receptor 1 family. | 0.979 |
Ccl11 | Ccr3 | ENSRNOP00000009756 | ENSRNOP00000008809 | Eotaxin; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions; Belongs to the intercrine beta (chemokine CC) family. | C-C chemokine receptor type 3; Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15. Subsequently transduces a signal by increasing the intracellular calcium ions level. In addition acts as a possible functional receptor for NARS1. | 0.999 |
Ccl11 | Ccr5 | ENSRNOP00000009756 | ENSRNOP00000073121 | Eotaxin; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions; Belongs to the intercrine beta (chemokine CC) family. | C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). | 0.995 |
Ccl11 | Csf2 | ENSRNOP00000009756 | ENSRNOP00000034235 | Eotaxin; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions; Belongs to the intercrine beta (chemokine CC) family. | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | 0.988 |
Ccl11 | Csf3 | ENSRNOP00000009756 | ENSRNOP00000011509 | Eotaxin; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions; Belongs to the intercrine beta (chemokine CC) family. | Granulocyte colony stimulating factor. | 0.987 |
Ccl11 | Cxcl10 | ENSRNOP00000009756 | ENSRNOP00000003649 | Eotaxin; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions; Belongs to the intercrine beta (chemokine CC) family. | C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...] | 0.966 |
Ccl11 | Ifng | ENSRNOP00000009756 | ENSRNOP00000009917 | Eotaxin; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions; Belongs to the intercrine beta (chemokine CC) family. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | 0.967 |
Ccl26 | Ccl11 | ENSRNOP00000001963 | ENSRNOP00000009756 | C-C motif chemokine ligand 26. | Eotaxin; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions; Belongs to the intercrine beta (chemokine CC) family. | 0.993 |
Ccl26 | Ccl27 | ENSRNOP00000001963 | ENSRNOP00000057330 | C-C motif chemokine ligand 26. | Chemokine (C-C motif) ligand 27 (Predicted), isoform CRA_b. | 0.989 |
Ccl26 | Ccl5 | ENSRNOP00000001963 | ENSRNOP00000014865 | C-C motif chemokine ligand 26. | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | 0.997 |
Ccl26 | Ccr1 | ENSRNOP00000001963 | ENSRNOP00000008772 | C-C motif chemokine ligand 26. | Macrophage inflammatory protein-1 alpha receptor; Belongs to the G-protein coupled receptor 1 family. | 0.910 |
Ccl26 | Ccr3 | ENSRNOP00000001963 | ENSRNOP00000008809 | C-C motif chemokine ligand 26. | C-C chemokine receptor type 3; Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15. Subsequently transduces a signal by increasing the intracellular calcium ions level. In addition acts as a possible functional receptor for NARS1. | 0.998 |
Ccl26 | Ccr5 | ENSRNOP00000001963 | ENSRNOP00000073121 | C-C motif chemokine ligand 26. | C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). | 0.837 |
Ccl26 | Csf2 | ENSRNOP00000001963 | ENSRNOP00000034235 | C-C motif chemokine ligand 26. | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | 0.461 |
Ccl26 | Cxcl10 | ENSRNOP00000001963 | ENSRNOP00000003649 | C-C motif chemokine ligand 26. | C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...] | 0.981 |
Ccl26 | Ifng | ENSRNOP00000001963 | ENSRNOP00000009917 | C-C motif chemokine ligand 26. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | 0.427 |
Ccl27 | Ccl11 | ENSRNOP00000057330 | ENSRNOP00000009756 | Chemokine (C-C motif) ligand 27 (Predicted), isoform CRA_b. | Eotaxin; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions; Belongs to the intercrine beta (chemokine CC) family. | 0.985 |