node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Csf2 | Csf3 | ENSRNOP00000034235 | ENSRNOP00000011509 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | Granulocyte colony stimulating factor. | 0.986 |
Csf2 | Ifnar1 | ENSRNOP00000034235 | ENSRNOP00000031611 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | Interferon (Alpha and beta) receptor 1 (Predicted), isoform CRA_a. | 0.788 |
Csf2 | Ifng | ENSRNOP00000034235 | ENSRNOP00000009917 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | 0.985 |
Csf2 | Ifngr1 | ENSRNOP00000034235 | ENSRNOP00000016286 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | Interferon gamma receptor 1. | 0.775 |
Csf2 | Ifngr2 | ENSRNOP00000034235 | ENSRNOP00000002779 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | Interferon gamma receptor 2 (Predicted). | 0.722 |
Csf2 | Il10 | ENSRNOP00000034235 | ENSRNOP00000006246 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] | 0.920 |
Csf2 | Il1a | ENSRNOP00000034235 | ENSRNOP00000071252 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. | 0.993 |
Csf2 | Il1b | ENSRNOP00000034235 | ENSRNOP00000006308 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. | 0.991 |
Csf2 | Jak1 | ENSRNOP00000034235 | ENSRNOP00000061649 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | Tyrosine-protein kinase. | 0.731 |
Csf2 | Jak2 | ENSRNOP00000034235 | ENSRNOP00000071877 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] | 0.927 |
Csf3 | Csf2 | ENSRNOP00000011509 | ENSRNOP00000034235 | Granulocyte colony stimulating factor. | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | 0.986 |
Csf3 | Ifnar1 | ENSRNOP00000011509 | ENSRNOP00000031611 | Granulocyte colony stimulating factor. | Interferon (Alpha and beta) receptor 1 (Predicted), isoform CRA_a. | 0.744 |
Csf3 | Ifng | ENSRNOP00000011509 | ENSRNOP00000009917 | Granulocyte colony stimulating factor. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | 0.975 |
Csf3 | Ifngr1 | ENSRNOP00000011509 | ENSRNOP00000016286 | Granulocyte colony stimulating factor. | Interferon gamma receptor 1. | 0.769 |
Csf3 | Ifngr2 | ENSRNOP00000011509 | ENSRNOP00000002779 | Granulocyte colony stimulating factor. | Interferon gamma receptor 2 (Predicted). | 0.650 |
Csf3 | Il10 | ENSRNOP00000011509 | ENSRNOP00000006246 | Granulocyte colony stimulating factor. | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] | 0.863 |
Csf3 | Il1a | ENSRNOP00000011509 | ENSRNOP00000071252 | Granulocyte colony stimulating factor. | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. | 0.973 |
Csf3 | Il1b | ENSRNOP00000011509 | ENSRNOP00000006308 | Granulocyte colony stimulating factor. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. | 0.975 |
Csf3 | Jak1 | ENSRNOP00000011509 | ENSRNOP00000061649 | Granulocyte colony stimulating factor. | Tyrosine-protein kinase. | 0.814 |
Csf3 | Jak2 | ENSRNOP00000011509 | ENSRNOP00000071877 | Granulocyte colony stimulating factor. | Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] | 0.951 |