node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Csf2 | Csf2rb | ENSRNOP00000034235 | ENSRNOP00000000203 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | Colony-stimulating factor 2 receptor beta common subunit. | 0.996 |
Csf2 | Il10 | ENSRNOP00000034235 | ENSRNOP00000006246 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] | 0.920 |
Csf2 | Il13 | ENSRNOP00000034235 | ENSRNOP00000010121 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. | 0.939 |
Csf2 | Il1b | ENSRNOP00000034235 | ENSRNOP00000006308 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. | 0.991 |
Csf2 | Il2 | ENSRNOP00000034235 | ENSRNOP00000023327 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. | 0.994 |
Csf2 | Il3 | ENSRNOP00000034235 | ENSRNOP00000030704 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. | 0.980 |
Csf2 | Il5 | ENSRNOP00000034235 | ENSRNOP00000010729 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. | 0.974 |
Csf2 | Il5ra | ENSRNOP00000034235 | ENSRNOP00000008403 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | Interleukin 5 receptor subunit alpha. | 0.864 |
Csf2 | Il7 | ENSRNOP00000034235 | ENSRNOP00000016091 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. | 0.840 |
Csf2 | Il9 | ENSRNOP00000034235 | ENSRNOP00000016187 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | Interleukin 9. | 0.853 |
Csf2rb | Csf2 | ENSRNOP00000000203 | ENSRNOP00000034235 | Colony-stimulating factor 2 receptor beta common subunit. | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | 0.996 |
Csf2rb | Il10 | ENSRNOP00000000203 | ENSRNOP00000006246 | Colony-stimulating factor 2 receptor beta common subunit. | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] | 0.759 |
Csf2rb | Il13 | ENSRNOP00000000203 | ENSRNOP00000010121 | Colony-stimulating factor 2 receptor beta common subunit. | Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. | 0.794 |
Csf2rb | Il2 | ENSRNOP00000000203 | ENSRNOP00000023327 | Colony-stimulating factor 2 receptor beta common subunit. | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. | 0.806 |
Csf2rb | Il3 | ENSRNOP00000000203 | ENSRNOP00000030704 | Colony-stimulating factor 2 receptor beta common subunit. | Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. | 0.994 |
Csf2rb | Il5 | ENSRNOP00000000203 | ENSRNOP00000010729 | Colony-stimulating factor 2 receptor beta common subunit. | Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. | 0.980 |
Csf2rb | Il5ra | ENSRNOP00000000203 | ENSRNOP00000008403 | Colony-stimulating factor 2 receptor beta common subunit. | Interleukin 5 receptor subunit alpha. | 0.960 |
Csf2rb | Il7 | ENSRNOP00000000203 | ENSRNOP00000016091 | Colony-stimulating factor 2 receptor beta common subunit. | Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. | 0.732 |
Csf2rb | Il9 | ENSRNOP00000000203 | ENSRNOP00000016187 | Colony-stimulating factor 2 receptor beta common subunit. | Interleukin 9. | 0.699 |
Il10 | Csf2 | ENSRNOP00000006246 | ENSRNOP00000034235 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | 0.920 |