node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Itga1 | Itga2 | ENSRNOP00000074337 | ENSRNOP00000072929 | Integrin alpha-1; Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth (By similarity). | Integrin subunit alpha 2; Belongs to the integrin alpha chain family. | 0.864 |
Itga1 | Itga3 | ENSRNOP00000074337 | ENSRNOP00000034608 | Integrin alpha-1; Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth (By similarity). | Integrin alpha 3 variant B; Belongs to the integrin alpha chain family. | 0.871 |
Itga1 | Itga4 | ENSRNOP00000074337 | ENSRNOP00000006880 | Integrin alpha-1; Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth (By similarity). | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | 0.844 |
Itga1 | Itga5 | ENSRNOP00000074337 | ENSRNOP00000071805 | Integrin alpha-1; Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth (By similarity). | Integrin alpha 5 (Mapped); Belongs to the integrin alpha chain family. | 0.827 |
Itga1 | Itga8 | ENSRNOP00000074337 | ENSRNOP00000022713 | Integrin alpha-1; Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth (By similarity). | Integrin subunit alpha 8; Belongs to the integrin alpha chain family. | 0.658 |
Itga1 | Itgav | ENSRNOP00000074337 | ENSRNOP00000069681 | Integrin alpha-1; Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth (By similarity). | Integrin subunit alpha V; Belongs to the integrin alpha chain family. | 0.826 |
Itga1 | Itgb6 | ENSRNOP00000074337 | ENSRNOP00000074271 | Integrin alpha-1; Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth (By similarity). | Integrin beta-6; Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R- G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity). | 0.934 |
Itga1 | Pxn | ENSRNOP00000074337 | ENSRNOP00000043928 | Integrin alpha-1; Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth (By similarity). | Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. | 0.928 |
Itga1 | Src | ENSRNOP00000074337 | ENSRNOP00000071837 | Integrin alpha-1; Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth (By similarity). | Proto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] | 0.707 |
Itga2 | Itga1 | ENSRNOP00000072929 | ENSRNOP00000074337 | Integrin subunit alpha 2; Belongs to the integrin alpha chain family. | Integrin alpha-1; Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth (By similarity). | 0.864 |
Itga2 | Itga3 | ENSRNOP00000072929 | ENSRNOP00000034608 | Integrin subunit alpha 2; Belongs to the integrin alpha chain family. | Integrin alpha 3 variant B; Belongs to the integrin alpha chain family. | 0.882 |
Itga2 | Itga4 | ENSRNOP00000072929 | ENSRNOP00000006880 | Integrin subunit alpha 2; Belongs to the integrin alpha chain family. | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | 0.858 |
Itga2 | Itga5 | ENSRNOP00000072929 | ENSRNOP00000071805 | Integrin subunit alpha 2; Belongs to the integrin alpha chain family. | Integrin alpha 5 (Mapped); Belongs to the integrin alpha chain family. | 0.877 |
Itga2 | Itga8 | ENSRNOP00000072929 | ENSRNOP00000022713 | Integrin subunit alpha 2; Belongs to the integrin alpha chain family. | Integrin subunit alpha 8; Belongs to the integrin alpha chain family. | 0.697 |
Itga2 | Itgav | ENSRNOP00000072929 | ENSRNOP00000069681 | Integrin subunit alpha 2; Belongs to the integrin alpha chain family. | Integrin subunit alpha V; Belongs to the integrin alpha chain family. | 0.889 |
Itga2 | Itgb6 | ENSRNOP00000072929 | ENSRNOP00000074271 | Integrin subunit alpha 2; Belongs to the integrin alpha chain family. | Integrin beta-6; Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R- G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity). | 0.937 |
Itga2 | Pxn | ENSRNOP00000072929 | ENSRNOP00000043928 | Integrin subunit alpha 2; Belongs to the integrin alpha chain family. | Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. | 0.932 |
Itga2 | Src | ENSRNOP00000072929 | ENSRNOP00000071837 | Integrin subunit alpha 2; Belongs to the integrin alpha chain family. | Proto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] | 0.778 |
Itga2 | Tgfb1 | ENSRNOP00000072929 | ENSRNOP00000028051 | Integrin subunit alpha 2; Belongs to the integrin alpha chain family. | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] | 0.479 |
Itga3 | Itga1 | ENSRNOP00000034608 | ENSRNOP00000074337 | Integrin alpha 3 variant B; Belongs to the integrin alpha chain family. | Integrin alpha-1; Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth (By similarity). | 0.871 |