node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dcaf11 | Nfe2l2 | ENSRNOP00000074435 | ENSRNOP00000002114 | DDB1- and CUL4-associated factor 11; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. | Nuclear factor erythroid 2-related factor 2; Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzymes, and promotes their expression, thereby neutralizing reactive electrophiles. In normal conditions, ubiquitinated and degraded in the cytoplasm by the BCR(KEAP1) complex. In response to oxidative stress, electrophile metabolites inhibit activity of the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2, hetero [...] | 0.539 |
Dcaf11 | Pou2f3 | ENSRNOP00000074435 | ENSRNOP00000012170 | DDB1- and CUL4-associated factor 11; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. | POU domain, class 2, transcription factor 3; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3'). Activates cytokeratin 10 (K10) gene expression. May serve a regulatory function with respect to epidermal development. Isoform 2 inhibits transactivation by OCT-1; Belongs to the POU transcription factor family. Class-2 subfamily. | 0.756 |
Dclk1 | Gnat3 | ENSRNOP00000019748 | ENSRNOP00000007032 | Serine/threonine-protein kinase DCLK1; Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system (By similarity). | Guanine nucleotide-binding protein G(t) subunit alpha-3; Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP- phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultim [...] | 0.465 |
Dclk1 | Pou2f3 | ENSRNOP00000019748 | ENSRNOP00000012170 | Serine/threonine-protein kinase DCLK1; Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system (By similarity). | POU domain, class 2, transcription factor 3; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3'). Activates cytokeratin 10 (K10) gene expression. May serve a regulatory function with respect to epidermal development. Isoform 2 inhibits transactivation by OCT-1; Belongs to the POU transcription factor family. Class-2 subfamily. | 0.643 |
Dclk1 | Trpm5 | ENSRNOP00000019748 | ENSRNOP00000039981 | Serine/threonine-protein kinase DCLK1; Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system (By similarity). | Transient receptor potential cation channel, subfamily M, member 5. | 0.780 |
Gcs1 | Pou2f3 | ENSRNOP00000011521 | ENSRNOP00000012170 | Mannosyl-oligosaccharide glucosidase. | POU domain, class 2, transcription factor 3; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3'). Activates cytokeratin 10 (K10) gene expression. May serve a regulatory function with respect to epidermal development. Isoform 2 inhibits transactivation by OCT-1; Belongs to the POU transcription factor family. Class-2 subfamily. | 0.577 |
Gnat3 | Dclk1 | ENSRNOP00000007032 | ENSRNOP00000019748 | Guanine nucleotide-binding protein G(t) subunit alpha-3; Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP- phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultim [...] | Serine/threonine-protein kinase DCLK1; Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system (By similarity). | 0.465 |
Gnat3 | Pou2f3 | ENSRNOP00000007032 | ENSRNOP00000012170 | Guanine nucleotide-binding protein G(t) subunit alpha-3; Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP- phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultim [...] | POU domain, class 2, transcription factor 3; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3'). Activates cytokeratin 10 (K10) gene expression. May serve a regulatory function with respect to epidermal development. Isoform 2 inhibits transactivation by OCT-1; Belongs to the POU transcription factor family. Class-2 subfamily. | 0.594 |
Gnat3 | Trpm5 | ENSRNOP00000007032 | ENSRNOP00000039981 | Guanine nucleotide-binding protein G(t) subunit alpha-3; Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP- phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultim [...] | Transient receptor potential cation channel, subfamily M, member 5. | 0.865 |
LOC103692171 | Pou2f3 | ENSRNOP00000074720 | ENSRNOP00000012170 | Mannosyl-oligosaccharide glucosidase; Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner; Belongs to the glycosyl hydrolase 63 family. | POU domain, class 2, transcription factor 3; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3'). Activates cytokeratin 10 (K10) gene expression. May serve a regulatory function with respect to epidermal development. Isoform 2 inhibits transactivation by OCT-1; Belongs to the POU transcription factor family. Class-2 subfamily. | 0.577 |
Nfe2l2 | Dcaf11 | ENSRNOP00000002114 | ENSRNOP00000074435 | Nuclear factor erythroid 2-related factor 2; Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzymes, and promotes their expression, thereby neutralizing reactive electrophiles. In normal conditions, ubiquitinated and degraded in the cytoplasm by the BCR(KEAP1) complex. In response to oxidative stress, electrophile metabolites inhibit activity of the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2, hetero [...] | DDB1- and CUL4-associated factor 11; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. | 0.539 |
Nfe2l2 | Pou2f3 | ENSRNOP00000002114 | ENSRNOP00000012170 | Nuclear factor erythroid 2-related factor 2; Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzymes, and promotes their expression, thereby neutralizing reactive electrophiles. In normal conditions, ubiquitinated and degraded in the cytoplasm by the BCR(KEAP1) complex. In response to oxidative stress, electrophile metabolites inhibit activity of the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2, hetero [...] | POU domain, class 2, transcription factor 3; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3'). Activates cytokeratin 10 (K10) gene expression. May serve a regulatory function with respect to epidermal development. Isoform 2 inhibits transactivation by OCT-1; Belongs to the POU transcription factor family. Class-2 subfamily. | 0.567 |
Pou2af1 | Pou2f1 | ENSRNOP00000061720 | ENSRNOP00000044416 | POU class 2 homeobox-associating factor 1. | POU domain, class 2, transcription factor 1; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). | 0.914 |
Pou2af1 | Pou2f2 | ENSRNOP00000061720 | ENSRNOP00000072745 | POU class 2 homeobox-associating factor 1. | POU domain protein. | 0.863 |
Pou2af1 | Pou2f3 | ENSRNOP00000061720 | ENSRNOP00000012170 | POU class 2 homeobox-associating factor 1. | POU domain, class 2, transcription factor 3; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3'). Activates cytokeratin 10 (K10) gene expression. May serve a regulatory function with respect to epidermal development. Isoform 2 inhibits transactivation by OCT-1; Belongs to the POU transcription factor family. Class-2 subfamily. | 0.574 |
Pou2f1 | Pou2af1 | ENSRNOP00000044416 | ENSRNOP00000061720 | POU domain, class 2, transcription factor 1; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). | POU class 2 homeobox-associating factor 1. | 0.914 |
Pou2f1 | Pou2f2 | ENSRNOP00000044416 | ENSRNOP00000072745 | POU domain, class 2, transcription factor 1; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). | POU domain protein. | 0.953 |
Pou2f1 | Pou2f3 | ENSRNOP00000044416 | ENSRNOP00000012170 | POU domain, class 2, transcription factor 1; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). | POU domain, class 2, transcription factor 3; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3'). Activates cytokeratin 10 (K10) gene expression. May serve a regulatory function with respect to epidermal development. Isoform 2 inhibits transactivation by OCT-1; Belongs to the POU transcription factor family. Class-2 subfamily. | 0.951 |
Pou2f2 | Pou2af1 | ENSRNOP00000072745 | ENSRNOP00000061720 | POU domain protein. | POU class 2 homeobox-associating factor 1. | 0.863 |
Pou2f2 | Pou2f1 | ENSRNOP00000072745 | ENSRNOP00000044416 | POU domain protein. | POU domain, class 2, transcription factor 1; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). | 0.953 |