node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cdc6 | Cdt1 | ENSRNOP00000071363 | ENSRNOP00000018923 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. | Chromatin licensing and DNA replication factor 1. | 0.999 |
Cdc6 | Ick | ENSRNOP00000071363 | ENSRNOP00000068950 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. | Serine/threonine-protein kinase ICK; Required for ciliogenesis, particularly in neuronal and retinal progenitor cells (By similarity). Phosphorylates KIF3A (By similarity). Involved in the control of ciliary length (By similarity). Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips (By similarity). May play a role in cardiac development. Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner and this regulation requires its kinase activi [...] | 0.727 |
Cdc6 | Mcm2 | ENSRNOP00000071363 | ENSRNOP00000022231 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. | DNA helicase; Belongs to the MCM family. | 0.999 |
Cdc6 | Mcm3 | ENSRNOP00000071363 | ENSRNOP00000017081 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. | DNA helicase; Belongs to the MCM family. | 0.999 |
Cdc6 | Mcm4 | ENSRNOP00000071363 | ENSRNOP00000002510 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. | DNA helicase; Belongs to the MCM family. | 0.999 |
Cdc6 | Mcm6 | ENSRNOP00000071363 | ENSRNOP00000004969 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. | DNA replication licensing factor MCM6; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.998 |
Cdc6 | Mcm7 | ENSRNOP00000071363 | ENSRNOP00000001825 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.998 |
Cdc6 | Orc3 | ENSRNOP00000071363 | ENSRNOP00000011085 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. | Origin recognition complex subunit 3; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3; Belongs to the ORC3 family. | 0.998 |
Cdc6 | Orc4 | ENSRNOP00000071363 | ENSRNOP00000006937 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 (By similarity). | 0.999 |
Cdc6 | Orc5 | ENSRNOP00000071363 | ENSRNOP00000073770 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. | Origin recognition complex, subunit 5. | 0.997 |
Cdt1 | Cdc6 | ENSRNOP00000018923 | ENSRNOP00000071363 | Chromatin licensing and DNA replication factor 1. | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. | 0.999 |
Cdt1 | Ick | ENSRNOP00000018923 | ENSRNOP00000068950 | Chromatin licensing and DNA replication factor 1. | Serine/threonine-protein kinase ICK; Required for ciliogenesis, particularly in neuronal and retinal progenitor cells (By similarity). Phosphorylates KIF3A (By similarity). Involved in the control of ciliary length (By similarity). Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips (By similarity). May play a role in cardiac development. Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner and this regulation requires its kinase activi [...] | 0.720 |
Cdt1 | Mcm2 | ENSRNOP00000018923 | ENSRNOP00000022231 | Chromatin licensing and DNA replication factor 1. | DNA helicase; Belongs to the MCM family. | 0.996 |
Cdt1 | Mcm3 | ENSRNOP00000018923 | ENSRNOP00000017081 | Chromatin licensing and DNA replication factor 1. | DNA helicase; Belongs to the MCM family. | 0.999 |
Cdt1 | Mcm4 | ENSRNOP00000018923 | ENSRNOP00000002510 | Chromatin licensing and DNA replication factor 1. | DNA helicase; Belongs to the MCM family. | 0.999 |
Cdt1 | Mcm6 | ENSRNOP00000018923 | ENSRNOP00000004969 | Chromatin licensing and DNA replication factor 1. | DNA replication licensing factor MCM6; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.997 |
Cdt1 | Mcm7 | ENSRNOP00000018923 | ENSRNOP00000001825 | Chromatin licensing and DNA replication factor 1. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.999 |
Cdt1 | Orc3 | ENSRNOP00000018923 | ENSRNOP00000011085 | Chromatin licensing and DNA replication factor 1. | Origin recognition complex subunit 3; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3; Belongs to the ORC3 family. | 0.997 |
Cdt1 | Orc4 | ENSRNOP00000018923 | ENSRNOP00000006937 | Chromatin licensing and DNA replication factor 1. | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 (By similarity). | 0.998 |
Cdt1 | Orc5 | ENSRNOP00000018923 | ENSRNOP00000073770 | Chromatin licensing and DNA replication factor 1. | Origin recognition complex, subunit 5. | 0.998 |