node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cul1 | Det1 | ENSRNOP00000007620 | ENSRNOP00000058942 | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | DET1 partner of COP1 E3 ubiquitin ligase. | 0.439 |
Cul1 | Fbxo2 | ENSRNOP00000007620 | ENSRNOP00000012670 | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | F-box only protein 2. | 0.932 |
Cul1 | Fbxo6 | ENSRNOP00000007620 | ENSRNOP00000012301 | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | F-box only protein 6; Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high- mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved i [...] | 0.797 |
Cul1 | Rbx1 | ENSRNOP00000007620 | ENSRNOP00000069049 | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | Ring-box 1. | 0.999 |
Cul1 | Skp1 | ENSRNOP00000007620 | ENSRNOP00000073214 | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] | 0.999 |
Det1 | Cul1 | ENSRNOP00000058942 | ENSRNOP00000007620 | DET1 partner of COP1 E3 ubiquitin ligase. | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | 0.439 |
Det1 | Fbxo6 | ENSRNOP00000058942 | ENSRNOP00000012301 | DET1 partner of COP1 E3 ubiquitin ligase. | F-box only protein 6; Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high- mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved i [...] | 0.589 |
Det1 | Rbx1 | ENSRNOP00000058942 | ENSRNOP00000069049 | DET1 partner of COP1 E3 ubiquitin ligase. | Ring-box 1. | 0.902 |
Det1 | Skp1 | ENSRNOP00000058942 | ENSRNOP00000073214 | DET1 partner of COP1 E3 ubiquitin ligase. | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] | 0.502 |
Engase | Fbxo6 | ENSRNOP00000038006 | ENSRNOP00000012301 | Similar to RIKEN cDNA D230014K01 (Predicted). | F-box only protein 6; Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high- mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved i [...] | 0.570 |
Fbxo2 | Cul1 | ENSRNOP00000012670 | ENSRNOP00000007620 | F-box only protein 2. | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | 0.932 |
Fbxo2 | Fbxo6 | ENSRNOP00000012670 | ENSRNOP00000012301 | F-box only protein 2. | F-box only protein 6; Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high- mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved i [...] | 0.918 |
Fbxo2 | Rbx1 | ENSRNOP00000012670 | ENSRNOP00000069049 | F-box only protein 2. | Ring-box 1. | 0.631 |
Fbxo2 | Skp1 | ENSRNOP00000012670 | ENSRNOP00000073214 | F-box only protein 2. | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] | 0.995 |
Fbxo6 | Cul1 | ENSRNOP00000012301 | ENSRNOP00000007620 | F-box only protein 6; Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high- mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved i [...] | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | 0.797 |
Fbxo6 | Det1 | ENSRNOP00000012301 | ENSRNOP00000058942 | F-box only protein 6; Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high- mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved i [...] | DET1 partner of COP1 E3 ubiquitin ligase. | 0.589 |
Fbxo6 | Engase | ENSRNOP00000012301 | ENSRNOP00000038006 | F-box only protein 6; Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high- mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved i [...] | Similar to RIKEN cDNA D230014K01 (Predicted). | 0.570 |
Fbxo6 | Fbxo2 | ENSRNOP00000012301 | ENSRNOP00000012670 | F-box only protein 6; Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high- mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved i [...] | F-box only protein 2. | 0.918 |
Fbxo6 | Liph | ENSRNOP00000012301 | ENSRNOP00000069088 | F-box only protein 6; Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high- mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved i [...] | Lipase member H; Hydrolyzes specifically phosphatidic acid (PA) to produce lysophosphatidic acid (LPA); Belongs to the AB hydrolase superfamily. Lipase family. | 0.644 |
Fbxo6 | Otud4 | ENSRNOP00000012301 | ENSRNOP00000024924 | F-box only protein 6; Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high- mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved i [...] | OTU deubiquitinase 4. | 0.640 |