node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ext1 | Ext2 | ENSRNOP00000031943 | ENSRNOP00000075401 | Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. | Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. | 0.998 |
Ext1 | Hs2st1 | ENSRNOP00000031943 | ENSRNOP00000016872 | Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. | Heparan sulfate 2-O-sulfotransferase 1, isoform CRA_a. | 0.791 |
Ext1 | Hs6st1 | ENSRNOP00000031943 | ENSRNOP00000019966 | Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. | Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. | 0.617 |
Ext1 | Ndst1 | ENSRNOP00000031943 | ENSRNOP00000025881 | Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. | Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate [...] | 0.862 |
Ext1 | Sdc3 | ENSRNOP00000031943 | ENSRNOP00000041634 | Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. | Syndecan-3; Cell surface proteoglycan that may bear heparan sulfate. May have a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism (By similarity). | 0.672 |
Ext1 | Sulf1 | ENSRNOP00000031943 | ENSRNOP00000064072 | Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. | Extracellular sulfatase Sulf-1; May be involved in the desulfation of sulfated glycosaminoglycans in the biosynthetic pathway and may play a role as an extracellular regulator of proteoglycan mediated signaling; Belongs to the sulfatase family. | 0.609 |
Ext2 | Ext1 | ENSRNOP00000075401 | ENSRNOP00000031943 | Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. | Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. | 0.998 |
Ext2 | Hs2st1 | ENSRNOP00000075401 | ENSRNOP00000016872 | Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. | Heparan sulfate 2-O-sulfotransferase 1, isoform CRA_a. | 0.734 |
Ext2 | Hs6st1 | ENSRNOP00000075401 | ENSRNOP00000019966 | Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. | Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. | 0.487 |
Ext2 | Ndst1 | ENSRNOP00000075401 | ENSRNOP00000025881 | Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. | Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate [...] | 0.874 |
Ext2 | Sdc3 | ENSRNOP00000075401 | ENSRNOP00000041634 | Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. | Syndecan-3; Cell surface proteoglycan that may bear heparan sulfate. May have a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism (By similarity). | 0.593 |
Ext2 | Sulf1 | ENSRNOP00000075401 | ENSRNOP00000064072 | Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. | Extracellular sulfatase Sulf-1; May be involved in the desulfation of sulfated glycosaminoglycans in the biosynthetic pathway and may play a role as an extracellular regulator of proteoglycan mediated signaling; Belongs to the sulfatase family. | 0.593 |
Hs2st1 | Ext1 | ENSRNOP00000016872 | ENSRNOP00000031943 | Heparan sulfate 2-O-sulfotransferase 1, isoform CRA_a. | Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. | 0.791 |
Hs2st1 | Ext2 | ENSRNOP00000016872 | ENSRNOP00000075401 | Heparan sulfate 2-O-sulfotransferase 1, isoform CRA_a. | Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. | 0.734 |
Hs2st1 | Hs6st1 | ENSRNOP00000016872 | ENSRNOP00000019966 | Heparan sulfate 2-O-sulfotransferase 1, isoform CRA_a. | Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. | 0.630 |
Hs2st1 | Ndst1 | ENSRNOP00000016872 | ENSRNOP00000025881 | Heparan sulfate 2-O-sulfotransferase 1, isoform CRA_a. | Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate [...] | 0.816 |
Hs2st1 | Sdc3 | ENSRNOP00000016872 | ENSRNOP00000041634 | Heparan sulfate 2-O-sulfotransferase 1, isoform CRA_a. | Syndecan-3; Cell surface proteoglycan that may bear heparan sulfate. May have a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism (By similarity). | 0.578 |
Hs2st1 | Sulf1 | ENSRNOP00000016872 | ENSRNOP00000064072 | Heparan sulfate 2-O-sulfotransferase 1, isoform CRA_a. | Extracellular sulfatase Sulf-1; May be involved in the desulfation of sulfated glycosaminoglycans in the biosynthetic pathway and may play a role as an extracellular regulator of proteoglycan mediated signaling; Belongs to the sulfatase family. | 0.582 |
Hs6st1 | Ext1 | ENSRNOP00000019966 | ENSRNOP00000031943 | Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. | Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. | 0.617 |
Hs6st1 | Ext2 | ENSRNOP00000019966 | ENSRNOP00000075401 | Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. | Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. | 0.487 |