STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Krt75Keratin, type II cytoskeletal 75; Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle (By similarity). (542 aa)    
Predicted Functional Partners:
Krtap13-1
Keratin-associated protein 13-1.
   
  
 0.614
Gpa33
Glycoprotein A33.
    
 
 0.509
Hephl1
Hephaestin-like 1; Belongs to the multicopper oxidase family.
      
 0.502
Krt1
Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK (By similarity).
  
0.500
Krt79
Keratin 79; Belongs to the intermediate filament family.
  
0.491
Krt8
Keratin, type II cytoskeletal 8; Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
  
0.490
Krt71
RCG50682, isoform CRA_a; Belongs to the intermediate filament family.
  
0.489
Tchh
Trichohyalin.
   
 
 0.480
LOC100910070
Lysozyme g-like protein 1-like.
   
  
 0.474
Lyg1
Lysozyme g-like protein; Belongs to the glycosyl hydrolase 23 family.
   
  
 0.473
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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