node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ift172 | Ift27 | ENSRNOP00000070902 | ENSRNOP00000008450 | Intraflagellar transport protein 172 homolog; Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway (By similarity); Belongs to the IFT172 family. | RAB, member of RAS oncogene family-like 4 (Predicted). | 0.987 |
Ift172 | Ift46 | ENSRNOP00000070902 | ENSRNOP00000019011 | Intraflagellar transport protein 172 homolog; Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway (By similarity); Belongs to the IFT172 family. | Intraflagellar transport protein 46 homolog; Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis (By similarity). | 0.994 |
Ift172 | Ift52 | ENSRNOP00000070902 | ENSRNOP00000059169 | Intraflagellar transport protein 172 homolog; Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway (By similarity); Belongs to the IFT172 family. | Intraflagellar transport 52. | 0.995 |
Ift172 | Ift57 | ENSRNOP00000070902 | ENSRNOP00000002684 | Intraflagellar transport protein 172 homolog; Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway (By similarity); Belongs to the IFT172 family. | Intraflagellar transport 57 homolog (Chlamydomonas) (Predicted). | 0.998 |
Ift172 | Ift74 | ENSRNOP00000070902 | ENSRNOP00000011336 | Intraflagellar transport protein 172 homolog; Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway (By similarity); Belongs to the IFT172 family. | Intraflagellar transport 74 homolog (Chlamydomonas). | 0.984 |
Ift172 | Ift80 | ENSRNOP00000070902 | ENSRNOP00000069823 | Intraflagellar transport protein 172 homolog; Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway (By similarity); Belongs to the IFT172 family. | Intraflagellar transport protein 80 homolog; Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia. | 0.998 |
Ift172 | Ift81 | ENSRNOP00000070902 | ENSRNOP00000061697 | Intraflagellar transport protein 172 homolog; Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway (By similarity); Belongs to the IFT172 family. | Intraflagellar transport protein 81 homolog; Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region. Required for ciliogenesis. Required for proper regulation of SHH signaling; Belongs to the IFT81 family. | 0.996 |
Ift172 | Ift88 | ENSRNOP00000070902 | ENSRNOP00000068425 | Intraflagellar transport protein 172 homolog; Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway (By similarity); Belongs to the IFT172 family. | Intraflagellar transport 88. | 0.996 |
Ift172 | Traf3ip1 | ENSRNOP00000070902 | ENSRNOP00000069939 | Intraflagellar transport protein 172 homolog; Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway (By similarity); Belongs to the IFT172 family. | TRAF3-interacting protein 1; Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules (By similarity). Involved in kidney development and epithelial morphogenesis. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels. Involved in ciliogenesis (By similarity). | 0.997 |
Ift172 | Ttc26 | ENSRNOP00000070902 | ENSRNOP00000034588 | Intraflagellar transport protein 172 homolog; Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway (By similarity); Belongs to the IFT172 family. | Intraflagellar transport protein 56; Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Required for efficient coupling between the accumulation of GLI2 and GLI3 at the ciliary tips and their dissociation from the negative regulator SUFU. Plays a key role in maintaining the integrity of the IFT complex B and the proper ciliary localization of the IFT compl [...] | 0.987 |
Ift27 | Ift172 | ENSRNOP00000008450 | ENSRNOP00000070902 | RAB, member of RAS oncogene family-like 4 (Predicted). | Intraflagellar transport protein 172 homolog; Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway (By similarity); Belongs to the IFT172 family. | 0.987 |
Ift27 | Ift46 | ENSRNOP00000008450 | ENSRNOP00000019011 | RAB, member of RAS oncogene family-like 4 (Predicted). | Intraflagellar transport protein 46 homolog; Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis (By similarity). | 0.997 |
Ift27 | Ift52 | ENSRNOP00000008450 | ENSRNOP00000059169 | RAB, member of RAS oncogene family-like 4 (Predicted). | Intraflagellar transport 52. | 0.996 |
Ift27 | Ift57 | ENSRNOP00000008450 | ENSRNOP00000002684 | RAB, member of RAS oncogene family-like 4 (Predicted). | Intraflagellar transport 57 homolog (Chlamydomonas) (Predicted). | 0.996 |
Ift27 | Ift74 | ENSRNOP00000008450 | ENSRNOP00000011336 | RAB, member of RAS oncogene family-like 4 (Predicted). | Intraflagellar transport 74 homolog (Chlamydomonas). | 0.996 |
Ift27 | Ift80 | ENSRNOP00000008450 | ENSRNOP00000069823 | RAB, member of RAS oncogene family-like 4 (Predicted). | Intraflagellar transport protein 80 homolog; Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia. | 0.984 |
Ift27 | Ift81 | ENSRNOP00000008450 | ENSRNOP00000061697 | RAB, member of RAS oncogene family-like 4 (Predicted). | Intraflagellar transport protein 81 homolog; Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region. Required for ciliogenesis. Required for proper regulation of SHH signaling; Belongs to the IFT81 family. | 0.994 |
Ift27 | Ift88 | ENSRNOP00000008450 | ENSRNOP00000068425 | RAB, member of RAS oncogene family-like 4 (Predicted). | Intraflagellar transport 88. | 0.995 |
Ift27 | Traf3ip1 | ENSRNOP00000008450 | ENSRNOP00000069939 | RAB, member of RAS oncogene family-like 4 (Predicted). | TRAF3-interacting protein 1; Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules (By similarity). Involved in kidney development and epithelial morphogenesis. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels. Involved in ciliogenesis (By similarity). | 0.995 |
Ift27 | Ttc26 | ENSRNOP00000008450 | ENSRNOP00000034588 | RAB, member of RAS oncogene family-like 4 (Predicted). | Intraflagellar transport protein 56; Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Required for efficient coupling between the accumulation of GLI2 and GLI3 at the ciliary tips and their dissociation from the negative regulator SUFU. Plays a key role in maintaining the integrity of the IFT complex B and the proper ciliary localization of the IFT compl [...] | 0.976 |