node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Apoa2 | Mug1 | ENSRNOP00000004662 | ENSRNOP00000019969 | Proapolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism; Belongs to the apolipoprotein A2 family. | Murinoglobulin-1; A proteinase activates the inhibitor by specific proteolysis in the bait region, which, by an unknown mechanism leads to reaction at the cysteinyl-glutamyl internal thiol ester site and to a conformational change, whereby the proteinase is trapped and/or covalently bound to the inhibitor. While in the tetrameric proteinase inhibitors steric inhibition is sufficiently strong, monomeric forms need a covalent linkage between the activated glutamyl residue of the original thiol ester and a terminal amino group of a lysine or another nucleophilic group on the proteinase, f [...] | 0.767 |
Apoa2 | Serpina3c | ENSRNOP00000004662 | ENSRNOP00000013896 | Proapolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism; Belongs to the apolipoprotein A2 family. | Serine protease inhibitor A3K; Binds to and inhibits kallikreins. Inhibits trypsin but not chymotrypsin or elastase. | 0.764 |
Klk1 | Serpina3c | ENSRNOP00000070080 | ENSRNOP00000013896 | Submandibular glandular kallikrein-9 heavy chain; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. This enzyme has a vasoconstrictor activity. KLK-9 has both a chymotrypsin-like and a trypsin-like properties. | Serine protease inhibitor A3K; Binds to and inhibits kallikreins. Inhibits trypsin but not chymotrypsin or elastase. | 0.871 |
Klk1c12 | Serpina3c | ENSRNOP00000025631 | ENSRNOP00000013896 | Glandular kallikrein-12, submandibular/renal; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. | Serine protease inhibitor A3K; Binds to and inhibits kallikreins. Inhibits trypsin but not chymotrypsin or elastase. | 0.886 |
Klk1c2 | Serpina3c | ENSRNOP00000025701 | ENSRNOP00000013896 | Tonin; This protein has both trypsin- and chymotrypsin-like activities, being able to release angiotensin II from angiotensin I or angiotensinogen. | Serine protease inhibitor A3K; Binds to and inhibits kallikreins. Inhibits trypsin but not chymotrypsin or elastase. | 0.880 |
Klk1c6 | Serpina3c | ENSRNOP00000074118 | ENSRNOP00000013896 | Kallikrein 1-related peptidase C6; Belongs to the peptidase S1 family. | Serine protease inhibitor A3K; Binds to and inhibits kallikreins. Inhibits trypsin but not chymotrypsin or elastase. | 0.886 |
Klk1c8 | Serpina3c | ENSRNOP00000066639 | ENSRNOP00000013896 | Prostatic glandular kallikrein-6; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin; Belongs to the peptidase S1 family. Kallikrein subfamily. | Serine protease inhibitor A3K; Binds to and inhibits kallikreins. Inhibits trypsin but not chymotrypsin or elastase. | 0.885 |
LOC100911689 | Serpina3c | ENSRNOP00000048581 | ENSRNOP00000013896 | T-kininogenase heavy chain; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. This protein may be involved in the regulation of renal function. | Serine protease inhibitor A3K; Binds to and inhibits kallikreins. Inhibits trypsin but not chymotrypsin or elastase. | 0.893 |
LOC103689933 | Serpina3c | ENSRNOP00000025777 | ENSRNOP00000013896 | Kallikrein 1-related peptidase C3; Belongs to the peptidase S1 family. | Serine protease inhibitor A3K; Binds to and inhibits kallikreins. Inhibits trypsin but not chymotrypsin or elastase. | 0.887 |
LOC103690048 | Serpina3c | ENSRNOP00000067862 | ENSRNOP00000013896 | Prostatic glandular kallikrein-6-like; Belongs to the peptidase S1 family. | Serine protease inhibitor A3K; Binds to and inhibits kallikreins. Inhibits trypsin but not chymotrypsin or elastase. | 0.897 |
Mug1 | Apoa2 | ENSRNOP00000019969 | ENSRNOP00000004662 | Murinoglobulin-1; A proteinase activates the inhibitor by specific proteolysis in the bait region, which, by an unknown mechanism leads to reaction at the cysteinyl-glutamyl internal thiol ester site and to a conformational change, whereby the proteinase is trapped and/or covalently bound to the inhibitor. While in the tetrameric proteinase inhibitors steric inhibition is sufficiently strong, monomeric forms need a covalent linkage between the activated glutamyl residue of the original thiol ester and a terminal amino group of a lysine or another nucleophilic group on the proteinase, f [...] | Proapolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism; Belongs to the apolipoprotein A2 family. | 0.767 |
Mug1 | Serpina3c | ENSRNOP00000019969 | ENSRNOP00000013896 | Murinoglobulin-1; A proteinase activates the inhibitor by specific proteolysis in the bait region, which, by an unknown mechanism leads to reaction at the cysteinyl-glutamyl internal thiol ester site and to a conformational change, whereby the proteinase is trapped and/or covalently bound to the inhibitor. While in the tetrameric proteinase inhibitors steric inhibition is sufficiently strong, monomeric forms need a covalent linkage between the activated glutamyl residue of the original thiol ester and a terminal amino group of a lysine or another nucleophilic group on the proteinase, f [...] | Serine protease inhibitor A3K; Binds to and inhibits kallikreins. Inhibits trypsin but not chymotrypsin or elastase. | 0.891 |
Serpina3c | Apoa2 | ENSRNOP00000013896 | ENSRNOP00000004662 | Serine protease inhibitor A3K; Binds to and inhibits kallikreins. Inhibits trypsin but not chymotrypsin or elastase. | Proapolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism; Belongs to the apolipoprotein A2 family. | 0.764 |
Serpina3c | Klk1 | ENSRNOP00000013896 | ENSRNOP00000070080 | Serine protease inhibitor A3K; Binds to and inhibits kallikreins. Inhibits trypsin but not chymotrypsin or elastase. | Submandibular glandular kallikrein-9 heavy chain; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. This enzyme has a vasoconstrictor activity. KLK-9 has both a chymotrypsin-like and a trypsin-like properties. | 0.871 |
Serpina3c | Klk1c12 | ENSRNOP00000013896 | ENSRNOP00000025631 | Serine protease inhibitor A3K; Binds to and inhibits kallikreins. Inhibits trypsin but not chymotrypsin or elastase. | Glandular kallikrein-12, submandibular/renal; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. | 0.886 |
Serpina3c | Klk1c2 | ENSRNOP00000013896 | ENSRNOP00000025701 | Serine protease inhibitor A3K; Binds to and inhibits kallikreins. Inhibits trypsin but not chymotrypsin or elastase. | Tonin; This protein has both trypsin- and chymotrypsin-like activities, being able to release angiotensin II from angiotensin I or angiotensinogen. | 0.880 |
Serpina3c | Klk1c6 | ENSRNOP00000013896 | ENSRNOP00000074118 | Serine protease inhibitor A3K; Binds to and inhibits kallikreins. Inhibits trypsin but not chymotrypsin or elastase. | Kallikrein 1-related peptidase C6; Belongs to the peptidase S1 family. | 0.886 |
Serpina3c | Klk1c8 | ENSRNOP00000013896 | ENSRNOP00000066639 | Serine protease inhibitor A3K; Binds to and inhibits kallikreins. Inhibits trypsin but not chymotrypsin or elastase. | Prostatic glandular kallikrein-6; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin; Belongs to the peptidase S1 family. Kallikrein subfamily. | 0.885 |
Serpina3c | LOC100911689 | ENSRNOP00000013896 | ENSRNOP00000048581 | Serine protease inhibitor A3K; Binds to and inhibits kallikreins. Inhibits trypsin but not chymotrypsin or elastase. | T-kininogenase heavy chain; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. This protein may be involved in the regulation of renal function. | 0.893 |
Serpina3c | LOC103689933 | ENSRNOP00000013896 | ENSRNOP00000025777 | Serine protease inhibitor A3K; Binds to and inhibits kallikreins. Inhibits trypsin but not chymotrypsin or elastase. | Kallikrein 1-related peptidase C3; Belongs to the peptidase S1 family. | 0.887 |