Calcr protein (Rattus norvegicus) - STRING interaction network

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Your Current Organism:

Rattus norvegicus

NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Adm	Calca	ENSRNOP00000035811	ENSRNOP00000014948	Proadrenomedullin N-20 terminal peptide; AM and PAMP are potent hypotensive and vasodilatator agents.	Calcitonin; Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.	0.956
Adm	Calcr	ENSRNOP00000035811	ENSRNOP00000013910	Proadrenomedullin N-20 terminal peptide; AM and PAMP are potent hypotensive and vasodilatator agents.	Calcitonin receptor; This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin; Belongs to the G-protein coupled receptor 2 family.	0.977
Adm	Calcrl	ENSRNOP00000035811	ENSRNOP00000070720	Proadrenomedullin N-20 terminal peptide; AM and PAMP are potent hypotensive and vasodilatator agents.	Calcitonin gene-related peptide type 1 receptor; Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.	0.999
Adm	Gnb1	ENSRNOP00000035811	ENSRNOP00000044340	Proadrenomedullin N-20 terminal peptide; AM and PAMP are potent hypotensive and vasodilatator agents.	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.681
Adm	Gnb2	ENSRNOP00000035811	ENSRNOP00000001911	Proadrenomedullin N-20 terminal peptide; AM and PAMP are potent hypotensive and vasodilatator agents.	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.631
Adm	Gng4	ENSRNOP00000035811	ENSRNOP00000065598	Proadrenomedullin N-20 terminal peptide; AM and PAMP are potent hypotensive and vasodilatator agents.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.724
Adm	Iapp	ENSRNOP00000035811	ENSRNOP00000016614	Proadrenomedullin N-20 terminal peptide; AM and PAMP are potent hypotensive and vasodilatator agents.	Islet amyloid polypeptide; Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.	0.982
Adm	Ramp1	ENSRNOP00000035811	ENSRNOP00000027012	Proadrenomedullin N-20 terminal peptide; AM and PAMP are potent hypotensive and vasodilatator agents.	Receptor activity-modifying protein 1; Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL.	0.990
Adm	Ramp2	ENSRNOP00000035811	ENSRNOP00000043210	Proadrenomedullin N-20 terminal peptide; AM and PAMP are potent hypotensive and vasodilatator agents.	Receptor activity-modifying protein 2; Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.	0.998
Adm	Ramp3	ENSRNOP00000035811	ENSRNOP00000074204	Proadrenomedullin N-20 terminal peptide; AM and PAMP are potent hypotensive and vasodilatator agents.	Receptor activity-modifying protein 3; Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.	0.997
Calca	Adm	ENSRNOP00000014948	ENSRNOP00000035811	Calcitonin; Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.	Proadrenomedullin N-20 terminal peptide; AM and PAMP are potent hypotensive and vasodilatator agents.	0.956
Calca	Calcr	ENSRNOP00000014948	ENSRNOP00000013910	Calcitonin; Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.	Calcitonin receptor; This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin; Belongs to the G-protein coupled receptor 2 family.	0.998
Calca	Calcrl	ENSRNOP00000014948	ENSRNOP00000070720	Calcitonin; Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.	Calcitonin gene-related peptide type 1 receptor; Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.	0.997
Calca	Gnb1	ENSRNOP00000014948	ENSRNOP00000044340	Calcitonin; Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.565
Calca	Gnb2	ENSRNOP00000014948	ENSRNOP00000001911	Calcitonin; Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.470
Calca	Gng4	ENSRNOP00000014948	ENSRNOP00000065598	Calcitonin; Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.682
Calca	Iapp	ENSRNOP00000014948	ENSRNOP00000016614	Calcitonin; Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.	Islet amyloid polypeptide; Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.	0.956
Calca	Ramp1	ENSRNOP00000014948	ENSRNOP00000027012	Calcitonin; Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.	Receptor activity-modifying protein 1; Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL.	0.997
Calca	Ramp2	ENSRNOP00000014948	ENSRNOP00000043210	Calcitonin; Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.	Receptor activity-modifying protein 2; Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.	0.974
Calca	Ramp3	ENSRNOP00000014948	ENSRNOP00000074204	Calcitonin; Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.	Receptor activity-modifying protein 3; Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.	0.952

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